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    PPA2 inorganic diphosphatase PPA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855309, updated on 29-Jun-2024

    Summary

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    Gene symbol
    PPA2
    Gene description
    inorganic diphosphatase PPA2
    Primary source
    FungiDB:YMR267W
    Locus tag
    YMR267W
    See related
    SGD:S000004880; AllianceGenome:SGD:S000004880; VEuPathDB:YMR267W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    IPP2
    Summary
    Enables inorganic diphosphatase activity. Involved in aerobic respiration. Located in mitochondrion. Used to study dilated cardiomyopathy and myocarditis. Orthologous to human PPA1 (inorganic pyrophosphatase 1) and PPA2 (inorganic pyrophosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PPA2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (801772..802704)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rsn1p Neighboring gene U6 snRNP complex subunit PRP24 Neighboring gene Tma23p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glutamic acid 472 and lysine 480 of the sodium pump alpha 1 subunit are essential for activity. Their conservation in pyrophosphatases suggests their involvement in recognition of ATP phosphates. Scheiner-Bobis G, et al. Biochemistry, 1999 Jul 20. PMID 10413494
    2. Inorganic pyrophosphate gives a membrane potential in yeast mitochondria, as measured with the permeant cation tetraphenylphosphonium. Pereira-da-Silva L, et al. Arch Biochem Biophys, 1993 Aug 1. PMID 8394052
    3. Studies on the utilization of inorganic pyrophosphate by different metabolic systems in yeast mitochondria. Pereira-da-Silva L, et al. Braz J Med Biol Res, 1993 Apr. PMID 8298510
    4. Interactions of calcium and magnesium with the mitochondrial inorganic pyrophosphatase from Saccharomyces cerevisiae. Uribe S, et al. Eur J Biochem, 1993 Oct 15. PMID 8223607
    5. Characterization of a mitochondrial inorganic pyrophosphatase in Saccharomyces cerevisiae. Lundin M, et al. Biochim Biophys Acta, 1992 Jan 16. PMID 1309654

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inorganic diphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inorganic diphosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphate-containing compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inorganic diphosphatase PPA2
    NP_013994.1
    • Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; human ortholog, PPA2, functionally complements the null mutant; mutations in human PPA2 cause a mitochondrial disease resulting in sudden unexpected cardiac arrest in infants

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      801772..802704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182774.1 → NP_013994.1  TPA: inorganic diphosphatase PPA2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W093, P28239
      UniProtKB/TrEMBL
      A0A6L0ZXT7, B3LMF4, B5VQ31, C7GR87, C8ZFD3
      Conserved Domains (1) summary
      cl00217
      Location:6 → 271
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28239.1

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