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    FPR3 peptidylprolyl isomerase FPR3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854901, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FPR3
    Official Full Name
    peptidylprolyl isomerase FPR3
    Primary source
    SGD:S000004539
    Locus tag
    YML074C
    See related
    AllianceGenome:SGD:S000004539; FungiDB:YML074C; VEuPathDB:YML074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NPI46
    Summary
    Enables macrolide binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in meiotic recombination checkpoint signaling and nucleosome assembly. Located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See FPR3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (120089..121324, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene War1p Neighboring gene hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 Neighboring gene ribosomal 60S subunit protein L6A Neighboring gene Tcb3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast immunophilin Fpr3 is a physiological substrate of the tyrosine-specific phosphoprotein phosphatase Ptp1. Wilson LK, et al. J Biol Chem, 1995 Oct 20. PMID 7559654
    2. Yeast NPI46 encodes a novel prolyl cis-trans isomerase that is located in the nucleolus. Shan X, et al. J Cell Biol, 1994 Aug. PMID 8051210, Free PMC Article
    3. Nuclear FKBPs, Fpr3 and Fpr4 affect genome-wide genes transcription. Park SK, et al. Mol Genet Genomics, 2014 Apr. PMID 24297734
    4. The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress. Padmanabhan N, et al. Mol Biol Cell, 2009 Jan. PMID 18946088, Free PMC Article
    5. The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity. Hochwagen A, et al. Cell, 2005 Sep 23. PMID 16179256

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Report show that Fpr3 regulates Cse4 proteolysis and the structural changes in CSe4 might be important for its interaction with Psh1.
      Title: Degradation of centromeric histone H3 variant Cse4 requires the Fpr3 peptidyl-prolyl Cis-Trans isomerase.
    2. The results thus provide a further demonstration for the elusive role of Fpr3 and Fpr4 in histone chaperones.
      Title: Nuclear FKBPs, Fpr3 and Fpr4 affect genome-wide genes transcription.
    3. The FK506 binding protein Fpr3 prevents premature adaptation to damage and thus serves to maintain recombination checkpoint activity.
      Title: The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables macrolide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic recombination checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in meiotic recombination checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidylprolyl isomerase FPR3
    NP_013637.1
    • Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR3 has a paralog, FPR4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      120089..121324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182433.1 → NP_013637.1  TPA: peptidylprolyl isomerase FPR3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013637.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0K9, P38911
      UniProtKB/TrEMBL
      G2WJY1, N1NYY3
      Conserved Domains (2) summary
      COG0545
      Location:287 → 410
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
      pfam17800
      Location:118 → 162
      NPL; Nucleoplasmin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38911.2

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