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    PEX30 peroxisome biogenesis protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851034, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PEX30
    Official Full Name
    peroxisome biogenesis protein
    Primary source
    SGD:S000004316
    Locus tag
    YLR324W
    See related
    AllianceGenome:SGD:S000004316; FungiDB:YLR324W; VEuPathDB:YLR324W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in ER-dependent peroxisome organization; membrane tubulation; and regulation of peroxisome organization. Located in endoplasmic reticulum tubular network and peroxisome. Is integral component of peroxisomal membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PEX30 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (779215..780786)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Sfh1p Neighboring gene U2-type spliceosomal complex subunit CWC24 Neighboring gene ribosomal 60S subunit protein L38 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A family of membrane-shaping proteins at ER subdomains regulates pre-peroxisomal vesicle biogenesis. Joshi AS, et al. J Cell Biol, 2016 Nov 21. PMID 27872254, Free PMC Article
    2. Production of the Fragrance Geraniol in Peroxisomes of a Product-Tolerant Baker's Yeast. Gerke J, et al. Front Bioeng Biotechnol, 2020. PMID 33102464, Free PMC Article
    3. A combined approach of quantitative interaction proteomics and live-cell imaging reveals a regulatory role for endoplasmic reticulum (ER) reticulon homology proteins in peroxisome biogenesis. David C, et al. Mol Cell Proteomics, 2013 Sep. PMID 23689284, Free PMC Article
    4. Pex19p binds Pex30p and Pex32p at regions required for their peroxisomal localization but separate from their peroxisomal targeting signals. Vizeacoumar FJ, et al. J Biol Chem, 2006 May 26. PMID 16551610
    5. Inp1p is a peroxisomal membrane protein required for peroxisome inheritance in Saccharomyces cerevisiae. Fagarasanu M, et al. J Cell Biol, 2005 Jun 6. PMID 15928207, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ER-dependent peroxisome organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peroxisome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of peroxisome organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cellular bud HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum tubular network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peroxisome biogenesis protein
    NP_013428.1
    • ER-resident protein involved in peroxisomal biogenesis; ER-localized protein that associates with peroxisomes; interacts with Pex29p and reticulons Rtn1p and Yop1p to regulate peroxisome biogenesis from the ER; role in peroxisomal-destined vesicular flow from the ER; partially redundant with Pex31p; may function at a step downstream of steps mediated by Pex28p and Pex29p; PEX30 has a paralog, PEX31, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      779215..780786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182213.1 → NP_013428.1  TPA: peroxisome biogenesis protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013428.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYW6, Q06169, Q66R43
      UniProtKB/TrEMBL
      B3RHJ9, C8ZDT5, G2WJE5, N1P010
      Conserved Domains (1) summary
      pfam06398
      Location:61 → 403
      Pex24p; Integral peroxisomal membrane peroxin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06169.1

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