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    Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297436, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Chchd6provided by RGD
    Official Full Name
    coiled-coil-helix-coiled-coil-helix domain containing 6provided by RGD
    Primary source
    RGD:1304561
    See related
    EnsemblRapid:ENSRNOG00000060248 AllianceGenome:RGD:1304561
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cellular response to DNA damage stimulus and cristae formation. Predicted to be located in cytosol and mitochondrial inner membrane. Predicted to be part of MICOS complex. Predicted to be active in mitochondrion. Orthologous to human CHCHD6 (coiled-coil-helix-coiled-coil-helix domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 337.0), Brain (RPKM 103.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chchd6 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (123360729..123581429, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (121803501..122024209, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (121340952..121565222, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102340 Neighboring gene plexin A1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene small nucleolar RNA SNORA48 Neighboring gene thioredoxin reductase 3 Neighboring gene high mobility group protein B2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cristae formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MICOS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MICOS complex subunit Mic25
    Names
    coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106608.1 → NP_001100078.1  MICOS complex subunit Mic25

      See identical proteins and their annotated locations for NP_001100078.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/Swiss-Prot
      D4A7N1
      UniProtKB/TrEMBL
      A0A8I5ZNH1
      Related
      ENSRNOP00000073575.2, ENSRNOT00000088753.3
      Conserved Domains (2) summary
      pfam05300
      Location:17 → 215
      DUF737; Protein of unknown function (DUF737)
      pfam06747
      Location:223 → 256
      CHCH; CHCH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      123360729..123581429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107369.1 → XP_038963297.1  MICOS complex subunit Mic25 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y7K5, A0A8I5ZNH1
      Related
      ENSRNOP00000077240.1, ENSRNOT00000108353.2
      Conserved Domains (2) summary
      pfam05300
      Location:22 → 186
      DUF737; Protein of unknown function (DUF737)
      pfam06747
      Location:195 → 228
      CHCH; CHCH domain

    2. XM_039107371.2 → XP_038963299.1  MICOS complex subunit Mic25 isoform X3

      Conserved Domains (2) summary
      pfam05300
      Location:55 → 104
      DUF737; Protein of unknown function (DUF737)
      pfam06747
      Location:113 → 146
      CHCH; CHCH domain

    3. XM_063285819.1 → XP_063141889.1  MICOS complex subunit Mic25 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A7N1.1 GenPept UniProtKB/Swiss-Prot:D4A7N1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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