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    Lars1 leucyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291624, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Lars1provided by RGD
    Official Full Name
    leucyl-tRNA synthetase 1provided by RGD
    Primary source
    RGD:1304962
    See related
    EnsemblRapid:ENSRNOG00000018304 AllianceGenome:RGD:1304962
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lars
    Summary
    Predicted to enable GTPase activator activity and catalytic activity, acting on a tRNA. Predicted to be involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and tRNA aminoacylation for protein translation. Predicted to be located in several cellular components, including endoplasmic reticulum; lysosome; and nuclear body. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Muscle (RPKM 219.7), Spleen (RPKM 206.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lars1 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (34452567..34507030, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (34201555..34256003, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (36524013..36579471, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 2 Neighboring gene uncharacterized LOC120098119 Neighboring gene 40S ribosomal protein SA pseudogene Neighboring gene PLAC8-like 1 Neighboring gene RNA binding motif protein 27 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of human GlnRS provides basis for the development of neurological disorders. Ognjenović J, et al. Nucleic Acids Res, 2016 Apr 20. PMID 26869582, Free PMC Article
    2. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Han JM, et al. Cell, 2012 Apr 13. PMID 22424946
    3. Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells. Kaminska M, et al. J Biol Chem, 2009 May 15. PMID 19289464, Free PMC Article
    4. Dissection of the structural organization of the aminoacyl-tRNA synthetase complex. Kaminska M, et al. J Biol Chem, 2009 Mar 6. PMID 19131329
    5. p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Kim JY, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060739, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105585

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminoacyl-tRNA editing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leucine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to leucine starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutaminyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leucyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine--tRNA ligase, cytoplasmic
    Names
    leucyl-tRNA synthetase, cytoplasmic
    NP_001009637.1
    XP_006254734.1
    XP_038952635.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009637.1 → NP_001009637.1  leucine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_001009637.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087655
      UniProtKB/TrEMBL
      A0A8I5ZW22, F1LQC0, Q5PPJ6
      Related
      ENSRNOP00000025284.6, ENSRNOT00000025284.9
      Conserved Domains (5) summary
      cd07959
      Location:757 → 876
      Anticodon_Ia_Leu_AEc; Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
      cd00812
      Location:527 → 759
      LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
      PLN02959
      Location:5 → 1064
      PLN02959; aminoacyl-tRNA ligase
      cl00015
      Location:47 → 231
      nt_trans; nucleotidyl transferase superfamily
      cl12020
      Location:858 → 907
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      34452567..34507030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254672.5 → XP_006254734.1  leucine--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZW22
      Conserved Domains (5) summary
      cd07959
      Location:757 → 876
      Anticodon_Ia_Leu_AEc; Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
      cd00812
      Location:527 → 759
      LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
      PLN02959
      Location:5 → 1064
      PLN02959; aminoacyl-tRNA ligase
      cl00015
      Location:47 → 231
      nt_trans; nucleotidyl transferase superfamily
      cl12020
      Location:858 → 907
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    2. XM_039096707.2 → XP_038952635.1  leucine--tRNA ligase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZW22
      Conserved Domains (1) summary
      PLN02959
      Location:5 → 1064
      PLN02959; aminoacyl-tRNA ligase
    Nucleotide Protein Strain
    Heading Accession and Version

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