Coq5 coenzyme Q5, methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Coq5provided by RGD
Official Full Name: coenzyme Q5, methyltransferaseprovided by RGD
Primary source: RGD:1310857
See related: EnsemblRapid:ENSRNOG00000001171 AllianceGenome:RGD:1310857
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310857
Summary: Predicted to enable 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity. Predicted to be involved in methylation and ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be part of ubiquinone biosynthesis complex. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Heart (RPKM 192.1), Adrenal (RPKM 144.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (46977632..46994575, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (41316922..41333855, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (47078753..47095438, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in methylation	ISO Inferred from Sequence Orthology more info
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extrinsic component of mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ubiquinone biosynthesis complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Names: coenzyme Q5 homolog, methyltransferase; ubiquinone biosynthesis methyltransferase COQ5, mitochondrial

NP_001034111.1

EC 2.1.1.201

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039022.1 → NP_001034111.1 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor

See identical proteins and their annotated locations for NP_001034111.1

Status: PROVISIONAL

Source sequence(s)

BC098719

UniProtKB/Swiss-Prot

Q4G064

Related

ENSRNOP00000001547.4, ENSRNOT00000001546.8

Conserved Domains (1) summary

PRK00216
Location:56 → 327

ubiE; bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE