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    Srp19 signal recognition particle 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291685, updated on 16-Aug-2024

    Summary

    Official Symbol
    Srp19provided by RGD
    Official Full Name
    signal recognition particle 19provided by RGD
    Primary source
    RGD:1308437
    See related
    EnsemblRapid:ENSRNOG00000020204 AllianceGenome:RGD:1308437
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 7S RNA binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be located in nucleolus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP19 (signal recognition particle 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 174.7), Brain (RPKM 161.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Srp19 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26205888..26212171)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (25931734..25937974)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27114822..27121062)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694952 Neighboring gene uncharacterized LOC102549857 Neighboring gene APC regulator of WNT signaling pathway Neighboring gene signal recognition particle 19, pseudogene 2 Neighboring gene receptor accessory protein 5 Neighboring gene polycystin 2 like 2, transient receptor potential cation channel Neighboring gene Set nuclear proto-oncogene, pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 7S RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of signal recognition particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of signal recognition particle, endoplasmic reticulum targeting ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    signal recognition particle 19 kDa protein
    NP_001099627.1
    XP_063133291.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106157.2NP_001099627.1  signal recognition particle 19 kDa protein

      See identical proteins and their annotated locations for NP_001099627.1

      Status: PROVISIONAL

      Source sequence(s)
      BC167043
      UniProtKB/TrEMBL
      A0A8I6AFH8, B2RZ66, F7F3N8
      Related
      ENSRNOP00000077002.1, ENSRNOT00000108712.2
      Conserved Domains (1) summary
      pfam01922
      Location:17115
      SRP19; SRP19 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      26205888..26212171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277221.1XP_063133291.1  signal recognition particle 19 kDa protein isoform X1