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    Btnl5 butyrophilin-like 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686048, updated on 17-Aug-2024

    Summary

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    Symbol
    Btnl5provided by RGD
    Full Name
    butyrophilin-like 5provided by RGD
    Primary source
    RGD:1598537
    See related
    AllianceGenome:RGD:1598537
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human BTNL3 (butyrophilin like 3); BTNL8 (butyrophilin like 8); and BTN3A3 (butyrophilin subfamily 3 member A3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 4.0), Spleen (RPKM 2.4) and 6 other tissues See more
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    Genomic context

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    See Btnl5 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4348162..4378309)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4366780..4376385)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (2723576..2733181, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene butyrophilin-like 7 Neighboring gene butyrophilin-like 6, pseudogene 1 Neighboring gene butyrophilin, subfamily 3, member A2 Neighboring gene uncharacterized LOC134483778 Neighboring gene testis expressed basic protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    butyrophilin-like 5
    Names
    butyrophilin-like protein 1
    butyrophilin-like protein 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166351.1 → NP_001159823.1  butyrophilin-like 5 isoform 2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      BX883043
      UniProtKB/TrEMBL
      F1M8A0
      Conserved Domains (3) summary
      smart00410
      Location:78 → 183
      IG_like; Immunoglobulin like
      cd13733
      Location:382 → 538
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cl11960
      Location:84 → 184
      Ig; Immunoglobulin domain

    2. NM_001430569.1 → NP_001417498.1  butyrophilin-like 5 isoform 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4348162..4378309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279509.1 → XP_063135579.1  butyrophilin-like 5 isoform X1

    2. XM_063279514.1 → XP_063135584.1  butyrophilin-like 5 isoform X4

    3. XM_063279516.1 → XP_063135586.1  butyrophilin-like 5 isoform X5

    4. XM_063279510.1 → XP_063135580.1  butyrophilin-like 5 isoform X1

    5. XM_063279515.1 → XP_063135585.1  butyrophilin-like 5 isoform X4

    6. XM_063279511.1 → XP_063135581.1  butyrophilin-like 5 isoform X1

    7. XM_063279512.1 → XP_063135582.1  butyrophilin-like 5 isoform X2

    8. XM_063279517.1 → XP_063135587.1  butyrophilin-like 5 isoform X5

    9. XM_063279513.1 → XP_063135583.1  butyrophilin-like 5 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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