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    Bcat1 branched chain amino acid transaminase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29592, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bcat1provided by RGD
    Official Full Name
    branched chain amino acid transaminase 1provided by RGD
    Primary source
    RGD:2195
    See related
    EnsemblRapid:ENSRNOG00000015514 AllianceGenome:RGD:2195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bcatc
    Summary
    Enables branched-chain-amino-acid transaminase activity and identical protein binding activity. Predicted to be involved in L-leucine biosynthetic process and L-valine biosynthetic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human BCAT1 (branched chain amino acid transaminase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 1453.7) and Uterus (RPKM 95.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bcat1 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (179695662..179777973, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (177964834..178046573, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (179259305..179340021, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554453 Neighboring gene small ribosomal subunit protein uS10-like Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene electron transfer flavoprotein regulatory factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids. García-Espinosa MA, et al. J Neurochem, 2007 Mar. PMID 17348860
    2. Upregulation of cytosolic branched chain aminotransferase in substantia nigra following developmental striatal target injury. Kholodilov NG, et al. Brain Res Mol Brain Res, 2000 Feb 22. PMID 10686349
    3. Cellular distribution of branched-chain amino acid aminotransferase isoenzymes among rat brain glial cells in culture. Bixel MG, et al. J Histochem Cytochem, 1997 May. PMID 9154155
    4. Changes in butyrylcholinesterase activity and serum lipids after oxprenolol and glibenclamide treatments in non-diabetic rats. Bradamante V, et al. Arzneimittelforschung, 2006. PMID 16572919
    5. Cloning and expression of the mammalian cytosolic branched chain aminotransferase isoenzyme. Hutson SM, et al. J Biol Chem, 1995 Dec 22. PMID 8530459

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BCAT1 alleviates early brain injury by inhibiting ferroptosis through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid hemorrhage.
      Title: BCAT1 alleviates early brain injury by inhibiting ferroptosis through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid hemorrhage.
    2. this metabolic enzyme is expressed throughout the brain and spinal cord, with distinct differences in regional and intracellular patterns of expression.
      Title: Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105472

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-isoleucine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-leucine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-valine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables branched-chain-amino-acid transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables branched-chain-amino-acid transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables branched-chain-amino-acid transaminase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-valine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in branched-chain amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within branched-chain amino acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    branched-chain-amino-acid aminotransferase, cytosolic
    Names
    BCAT(c)
    branched chain amino acid transaminase 1, cytosolic
    branched chain aminotransferase 1, cytosolic
    NP_001380930.1
    NP_058949.1
    XP_008761592.1
    XP_008761594.1
    XP_008761595.1
    XP_063141757.1
    XP_063141758.1
    XP_063141759.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394001.2 → NP_001380930.1  branched-chain-amino-acid aminotransferase, cytosolic isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K7K5, A6IMZ3, Q99JD5
      Related
      ENSRNOP00000074245.1, ENSRNOT00000080410.3
      Conserved Domains (1) summary
      PRK13357
      Location:52 → 391
      PRK13357; branched-chain amino acid aminotransferase; Provisional

    2. NM_017253.4 → NP_058949.1  branched-chain-amino-acid aminotransferase, cytosolic isoform 1

      See identical proteins and their annotated locations for NP_058949.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P54690
      UniProtKB/TrEMBL
      A6IMZ1, A6IMZ3
      Related
      ENSRNOP00000085607.1, ENSRNOT00000119115.2
      Conserved Domains (2) summary
      PRK13357
      Location:64 → 403
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:105 → 400
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      179695662..179777973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285688.1 → XP_063141758.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X3

      UniProtKB/TrEMBL
      A0A0G2K7K5, Q99JD5

    2. XM_008763372.3 → XP_008761594.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X3

      See identical proteins and their annotated locations for XP_008761594.1

      UniProtKB/TrEMBL
      A0A0G2K7K5, A6IMZ3, Q99JD5
      Conserved Domains (1) summary
      PRK13357
      Location:52 → 391
      PRK13357; branched-chain amino acid aminotransferase; Provisional

    3. XM_063285689.1 → XP_063141759.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X4

      UniProtKB/TrEMBL
      A0A0G2K7K5, Q99JD5
      Related
      ENSRNOP00000090195.1, ENSRNOT00000117044.2

    4. XM_063285687.1 → XP_063141757.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X1

    5. XM_008763370.4 → XP_008761592.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVC5, A6IMZ3
      Conserved Domains (2) summary
      PRK13357
      Location:81 → 420
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:122 → 417
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    6. XM_008763373.3 → XP_008761595.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X5

      See identical proteins and their annotated locations for XP_008761595.1

      UniProtKB/TrEMBL
      A0A8L2QAQ9, A6IMZ4
      Related
      ENSRNOP00000021193.6, ENSRNOT00000021193.9
      Conserved Domains (2) summary
      PRK13357
      Location:51 → 390
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:92 → 387
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54690.1 GenPept UniProtKB/Swiss-Prot:P54690

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