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    OLA1 Obg like ATPase 1 [ Homo sapiens (human) ]

    Gene ID: 29789, updated on 3-Nov-2024

    Summary

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    Official Symbol
    OLA1provided by HGNC
    Official Full Name
    Obg like ATPase 1provided by HGNC
    Primary source
    HGNC:HGNC:28833
    See related
    Ensembl:ENSG00000138430 MIM:611175; AllianceGenome:HGNC:28833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DOC45; GBP45; GTBP9; GTPBP9; PTD004
    Summary
    This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]
    Expression
    Ubiquitous expression in brain (RPKM 15.5), thyroid (RPKM 14.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See OLA1 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (174072447..174248532, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (174558800..174736966, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (174937175..175113260, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr2:174914257-174914460 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:174916218-174917417 Neighboring gene uncharacterized LOC105373746 Neighboring gene ribosomal protein SA pseudogene 24 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:174927623-174928242 Neighboring gene NANOG hESC enhancer GRCh37_chr2:174948503-174949105 Neighboring gene VISTA enhancer hs243 Neighboring gene VISTA enhancer hs244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12123 Neighboring gene uncharacterized LOC124907906 Neighboring gene MPRA-validated peak3933 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12124 Neighboring gene RNA, 7SL, cytoplasmic 65, pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 39 Neighboring gene LRRC2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Decreased OLA1 (Obg-Like ATPase-1) Expression Drives Ubiquitin-Proteasome Pathways to Downregulate Mitochondrial SOD2 (Superoxide Dismutase) in Persistent Pulmonary Hypertension of the Newborn. Schultz A, et al. Hypertension, 2019 Oct. PMID 31476900, Free PMC Article
    2. Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β-inhibitor 2-PP1 positive feedback loop. Xu D, et al. Oncotarget, 2016 Jan 19. PMID 26655089, Free PMC Article
    3. OLA1, an Obg-like ATPase, suppresses antioxidant response via nontranscriptional mechanisms. Zhang J, et al. Proc Natl Acad Sci U S A, 2009 Sep 8. PMID 19706404, Free PMC Article
    4. OLA1 contributes to epithelial-mesenchymal transition in lung cancer by modulating the GSK3β/snail/E-cadherin signaling. Bai L, et al. Oncotarget, 2016 Mar 1. PMID 26863455, Free PMC Article
    5. DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies. Sun H, et al. Mol Cancer Res, 2010 Jan. PMID 20053727

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinicopathological significance of Obg-like ATPase 1 and its association with Snail in gastric cancer.
      Title: Clinicopathological significance of  Obg-like ATPase 1 and its association with Snail in gastric cancer.
    2. OLA1 Phosphorylation Governs the Mitochondrial Bioenergetic Function of Pulmonary Vascular Cells.
      Title: OLA1 Phosphorylation Governs the Mitochondrial Bioenergetic Function of Pulmonary Vascular Cells.
    3. OLA1 promotes colorectal cancer tumorigenesis by activation of HIF1alpha/CA9 axis.
      Title: OLA1 promotes colorectal cancer tumorigenesis by activation of HIF1α/CA9 axis.
    4. N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer.
      Title: N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer.
    5. HIV p17 enhances T cell proliferation by suppressing autophagy through the p17-OLA1-GSK3beta axis under nutrient starvation.
      Title: HIV p17 enhances T cell proliferation by suppressing autophagy through the p17-OLA1-GSK3β axis under nutrient starvation.
    6. Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGFbeta/SMAD2 axis in vitro.
      Title: Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGFβ/SMAD2 axis in vitro.
    7. Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma.
      Title: Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma.
    8. It explores the various functional roles of hOLA1 in mammalian cells during stress response and cancer progression, and of YchF in bacterial cells.
      Title: Cellular roles of the human Obg-like ATPase 1 (hOLA1) and its YchF homologs.
    9. We conclude that decreased OLA1 expression accounts for SOD2 downregulation in persistent pulmonary hypertension of the newborn.
      Title: Decreased OLA1 (Obg-Like ATPase-1) Expression Drives Ubiquitin-Proteasome Pathways to Downregulate Mitochondrial SOD2 (Superoxide Dismutase) in Persistent Pulmonary Hypertension of the Newborn.
    10. these data reveal that the OLA1-BARD1 interaction is important for the regulation of centrosome number. Regulation of centrosome number by BRCA1/BARD1 together with OLA1 is important for the genome integrity to prevent tumor development.
      Title: BRCA1-Interacting Protein OLA1 Requires Interaction with BARD1 to Regulate Centrosome Number.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with Obg-like ATPase 1 (OLA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    matrix gag HIV-1 MA interacts with OLA1 PubMed
    gag HIV-1 MA is identified to have a physical interaction with Obg-like ATPase 1 (OLA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp313H1942

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosomal large subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    obg-like ATPase 1
    Names
    DNA damage-regulated overexpressed in cancer 45 protein
    GTP-binding protein 9 (putative)
    GTP-binding protein PTD004
    homologous yeast-44.2 protein
    NP_001011708.1
    NP_001315617.1
    NP_037473.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051001.1 RefSeqGene

      Range
      5139..181224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001011708.3 → NP_001011708.1  obg-like ATPase 1 isoform 2

      See identical proteins and their annotated locations for NP_001011708.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC016737, AK074710
      Consensus CDS
      CCDS42779.1
      UniProtKB/TrEMBL
      Q53SQ6
      Related
      ENSP00000340167.5, ENST00000344357.9
      Conserved Domains (1) summary
      PTZ00258
      Location:1 → 232
      PTZ00258; GTP-binding protein; Provisional

    2. NM_001328688.2 → NP_001315617.1  obg-like ATPase 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC016737, AK225112
      UniProtKB/TrEMBL
      J3KQ32
      Conserved Domains (1) summary
      PTZ00258
      Location:1 → 369
      PTZ00258; GTP-binding protein; Provisional

    3. NM_013341.5 → NP_037473.3  obg-like ATPase 1 isoform 1

      See identical proteins and their annotated locations for NP_037473.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC016737, BC012842
      Consensus CDS
      CCDS2255.1
      UniProtKB/Swiss-Prot
      D7EHM2, Q5BJD7, Q8NCI8, Q96CU1, Q96SV2, Q9NTK5, Q9P1D3, Q9UNY9, Q9Y6G4
      UniProtKB/TrEMBL
      J3KQ32
      Related
      ENSP00000284719.3, ENST00000284719.8
      Conserved Domains (1) summary
      PTZ00258
      Location:1 → 390
      PTZ00258; GTP-binding protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      174072447..174248532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      174558800..174736966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NTK5.2 GenPept UniProtKB/Swiss-Prot:Q9NTK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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