HTR7 5-hydroxytryptamine receptor 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HTR7provided by HGNC
Official Full Name: 5-hydroxytryptamine receptor 7provided by HGNC
Primary source: HGNC:HGNC:5302
See related: Ensembl:ENSG00000148680 MIM:182137; AllianceGenome:HGNC:5302
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 5-HT7
Summary: The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 6.1), urinary bladder (RPKM 2.0) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (90740823..90858039, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (91624488..91741713, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (92500580..92617796, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and induces proliferation of triple-negative breast cancer cells through FOXM1.
Title: Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and induces proliferation of triple-negative breast cancer cells through FOXM1.
5-HT7 receptors in Alzheimer's disease.
Title: 5-HT(7) receptors in Alzheimer's disease.
5-HT7 receptors as a new target for prostate cancer physiopathology and treatment: an experimental study on PC-3 cells and FFPE tissues.
Title: 5-HT7 receptors as a new target for prostate cancer physiopathology and treatment: an experimental study on PC-3 cells and FFPE tissues.
Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized with isoflurane.
Title: Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized with isoflurane.
Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease.
Title: Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease.
Stimulating DDX3 expression by serotonin 5-HT receptor 7 through phosphorylation of p53 via the AC-PKA-ERK signaling pathway.
Title: Stimulating DDX3 expression by serotonin 5-HT receptor 7 through phosphorylation of p53 via the AC-PKA-ERK signaling pathway.
5-HT7 receptors are widely expressed in a vast repertoire of immune and non-immune cells. The receptor has diverse -and even discrepant- roles in the immune response. [review]
Title: Role of 5-HT(7) receptors in the immune system in health and disease.
MiRNA-29a is upregulated in and HTR7 is downregulated in irritable bowel syndrome (IBS). HTR7 is a direct target of miRNA-29a. MiRNA-29a plays a role in visceral hyperalgesia pathogenesis of IBS.
Title: MiRNA-29a modulates visceral hyperalgesia in irritable bowel syndrome by targeting HTR7.
the impact of template choice, alignment, and model building methods on the homology model of 5-HT7R is addressed.
Title: Improvising 5-HT(7)R homology model for design of high affinity ligands: model validation with docking, embrace minimization, MM-GBSA, and molecular dynamic simulations.
zinc can act as a negative allosteric inhibitor of 5-HT7 receptors.
Title: Allosteric Inhibition of Serotonin 5-HT(7) Receptors by Zinc Ions.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants and gene expression associated with white matter microstructure in the human brain. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH66814 (e-PCR)
- UniSTS:39426

D10S564 (e-PCR), detects polymorphism
- UniSTS:68127

HTR7 (e-PCR)
- UniSTS:511811

Htr7 (e-PCR), detects polymorphism
- UniSTS:511811

HTR7_1275 (e-PCR)
- UniSTS:277342

HTR7_v375 (e-PCR)
- UniSTS:277342

SHGC-132538 (e-PCR)
- UniSTS:173941

D10S564 (e-PCR), detects polymorphism
- UniSTS:73626

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in blood circulation	TAS Traceable Author Statement more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 7

Names: 5-HT-7; 5-HT-X; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029218.1 RefSeqGene

Range

4876..122092

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000872.5 → NP_000863.1 5-hydroxytryptamine receptor 7 isoform a

See identical proteins and their annotated locations for NP_000863.1

Status: REVIEWED

Description

Transcript Variant: This variant (a) results from the alternative usage of the first of two tandemly arranged splice donor sites at the 5' end of intron 2, which causes the protein to have a 13 amino acid longer carboxy tail relative to isoform b.

Source sequence(s)

AL360011, BC047526, BG108256

Consensus CDS

CCDS7409.1

UniProtKB/Swiss-Prot

P34969

Related

ENSP00000277874.6, ENST00000277874.10

Conserved Domains (1) summary

cd15329
Location:97 → 395

7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_019859.4 → NP_062873.1 5-hydroxytryptamine receptor 7 isoform d

See identical proteins and their annotated locations for NP_062873.1

Status: REVIEWED

Description

Transcript Variant: This variant (d) results from the inclusion of a 98 base pair exon cassette (exon D) at the exon II/exon III boundary, as compared to splice variant a. The inclusion of exon D results in a protein with a carboxy terminal end 34 amino acids longer than the splice variant a protein.

Source sequence(s)

AL360011, BC047526, BG108256, U68488

Consensus CDS

CCDS7408.1

UniProtKB/Swiss-Prot

B5BUP6, P34969, P78336, P78372, P78516, Q5VX01, Q5VX02, Q5VX03

Related

ENSP00000337949.3, ENST00000336152.8

Conserved Domains (2) summary

pfam00001
Location:98 → 384

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:98 → 215

7tm_4; Olfactory receptor
NM_019860.4 → NP_062874.1 5-hydroxytryptamine receptor 7 isoform b

See identical proteins and their annotated locations for NP_062874.1

Status: REVIEWED

Description

Transcript Variant: This variant (b) results from the alternative usage of the second of the two tandemly arranged splice donor sites at the 5' end of intron 2, which causes an in-frame stop codon and shortens the protein's carboxy tail by 13 amino acids relative to isoform a.

Source sequence(s)

AL360011, BC047526, BG108256, U68487

Consensus CDS

CCDS7410.1

UniProtKB/Swiss-Prot

P34969

Related

ENSP00000360784.2, ENST00000371719.2

Conserved Domains (1) summary

cd15329
Location:97 → 395

7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

90740823..90858039 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024447973.2 → XP_024303741.1 5-hydroxytryptamine receptor 7 isoform X1

Conserved Domains (2) summary

cd15329
Location:3 → 19

7tmA_5-HT7; TM helix 4 [structural motif]

cl28897
Location:1 → 197

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily