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    OSCAR osteoclast associated Ig-like receptor [ Homo sapiens (human) ]

    Gene ID: 126014, updated on 28-Oct-2024

    Summary

    Official Symbol
    OSCARprovided by HGNC
    Official Full Name
    osteoclast associated Ig-like receptorprovided by HGNC
    Primary source
    HGNC:HGNC:29960
    See related
    Ensembl:ENSG00000170909 MIM:606862; AllianceGenome:HGNC:29960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIGR3; PIgR-3
    Summary
    Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
    Expression
    Biased expression in lung (RPKM 7.4), bone marrow (RPKM 7.3) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See OSCAR in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54094668..54100803, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57173230..57179492, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54597933..54604094, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene V-set and transmembrane domain containing 1 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54605952-54606928 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54617323-54618196 Neighboring gene TCF3 fusion partner Neighboring gene PRPF31 antisense RNA 1 Neighboring gene pre-mRNA processing factor 31

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC33613

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables collagen receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables collagen receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables collagen receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in collagen-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in specific granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    osteoclast-associated immunoglobulin-like receptor
    Names
    osteoclast associated receptor OSCAR-S1
    osteoclast associated receptor OSCAR-S2
    osteoclast associated, immunoglobulin-like receptor
    poly-Ig receptor 3
    polymeric immunoglobulin receptor 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282349.3NP_001269278.1  osteoclast-associated immunoglobulin-like receptor isoform 6 precursor

      See identical proteins and their annotated locations for NP_001269278.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS74444.1
      UniProtKB/Swiss-Prot
      B7WNS2, Q5GRG5, Q8IYS5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
      Related
      ENSP00000365808.2, ENST00000284648.10
      Conserved Domains (2) summary
      smart00410
      Location:38100
      IG_like; Immunoglobulin like
      cl11960
      Location:31124
      Ig; Immunoglobulin domain
    2. NM_001282350.3NP_001269279.1  osteoclast-associated immunoglobulin-like receptor isoform 7 precursor

      See identical proteins and their annotated locations for NP_001269279.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (7) is shorter, compared to isoform 1.
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS62789.1
      UniProtKB/Swiss-Prot
      B7WNS2, Q5GRG5, Q8IYS5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
      Related
      ENSP00000375641.1, ENST00000391761.5
      Conserved Domains (2) summary
      smart00410
      Location:2789
      IG_like; Immunoglobulin like
      cl11960
      Location:20113
      Ig; Immunoglobulin domain
    3. NM_130771.6NP_570127.3  osteoclast-associated immunoglobulin-like receptor isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS12873.1
      UniProtKB/TrEMBL
      A0A087X1R2, A0A0G2JMM7
      Related
      ENSP00000348927.3, ENST00000356532.7
      Conserved Domains (2) summary
      smart00410
      Location:42104
      IG_like; Immunoglobulin like
      cl11960
      Location:35128
      Ig; Immunoglobulin domain
    4. NM_133168.6NP_573398.2  osteoclast-associated immunoglobulin-like receptor isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons in the central coding region and lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS12874.1
      UniProtKB/TrEMBL
      A0A0A0MR14, A0A0G2JMM7
      Related
      ENSP00000304523.5, ENST00000351806.8
      Conserved Domains (2) summary
      smart00410
      Location:2789
      IG_like; Immunoglobulin like
      cl11960
      Location:20113
      Ig; Immunoglobulin domain
    5. NM_133169.6NP_573399.2  osteoclast-associated immunoglobulin-like receptor isoform 4 precursor

      See identical proteins and their annotated locations for NP_573399.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region and lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS12875.1
      UniProtKB/TrEMBL
      A0A0A0MRF2, A0A0G2JMM7
      Related
      ENSP00000351145.4, ENST00000358375.9
      Conserved Domains (2) summary
      smart00410
      Location:38100
      IG_like; Immunoglobulin like
      cl11960
      Location:31124
      Ig; Immunoglobulin domain
    6. NM_206818.4NP_996554.2  osteoclast-associated immunoglobulin-like receptor isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS12876.1
      UniProtKB/Swiss-Prot
      B7WNS2, Q5GRG5, Q8IYS5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
      UniProtKB/TrEMBL
      A0A087WV17
      Related
      ENSP00000352671.4, ENST00000359649.8
      Conserved Domains (2) summary
      smart00410
      Location:42104
      IG_like; Immunoglobulin like
      cl11960
      Location:35128
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54094668..54100803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NW_003571056.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NW_003571057.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NW_003571058.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NW_003571059.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_8

    Genomic

    1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57173230..57179492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_206817.1: Suppressed sequence

      Description
      NM_206817.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.