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    Tacc3 transforming, acidic coiled-coil containing protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360962, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Tacc3provided by RGD
    Official Full Name
    transforming, acidic coiled-coil containing protein 3provided by RGD
    Primary source
    RGD:1302948
    See related
    EnsemblRapid:ENSRNOG00000017259 AllianceGenome:RGD:1302948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in Thymus (RPKM 221.5), Spleen (RPKM 155.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tacc3 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81275755..81289894, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77051209..77065343, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82336283..82350069, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 3 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA18 Neighboring gene transmembrane protein 129, E3 ubiquitin ligase Neighboring gene stem-loop histone mRNA binding protein Neighboring gene family with sequence similarity 53, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. Cheeseman LP, et al. J Cell Sci, 2013 May 1. PMID 23532825, Free PMC Article
    2. TACC3 expression and localization in the murine egg and ovary. Hao Z, et al. Mol Reprod Dev, 2002 Nov. PMID 12237944
    3. The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. Piekorz RP, et al. EMBO J, 2002 Feb 15. PMID 11847113, Free PMC Article
    4. A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. Booth DG, et al. EMBO J, 2011 Mar 2. PMID 21297582, Free PMC Article
    5. Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development. Sadek CM, et al. Mech Dev, 2000 Oct. PMID 11025203

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within astral microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cytoplasmic sequestering of transcription factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within interkinetic nuclear migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization involved in mitosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transforming acidic coiled-coil-containing protein 3
    Names
    transforming acidic coiled coil 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004424.3 → NP_001004424.3  transforming acidic coiled-coil-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZK91, A0A8I6ATD8
      Related
      ENSRNOP00000097835.1, ENSRNOT00000103703.2
      Conserved Domains (2) summary
      PHA03247
      Location:137 → 381
      PHA03247; large tegument protein UL36; Provisional
      pfam05010
      Location:387 → 580
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      81275755..81289894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251329.4 → XP_006251391.2  transforming acidic coiled-coil-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y652, A0A8I5ZK91
      Related
      ENSRNOP00000076588.1, ENSRNOT00000097797.2
      Conserved Domains (2) summary
      PHA03247
      Location:248 → 492
      PHA03247; large tegument protein UL36; Provisional
      pfam05010
      Location:498 → 691
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    2. XM_006251330.5 → XP_006251392.2  transforming acidic coiled-coil-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      D3Z962
      Conserved Domains (2) summary
      PRK03427
      Location:263 → 371
      PRK03427; cell division protein ZipA; Provisional
      pfam05010
      Location:498 → 616
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    3. XM_063273388.1 → XP_063129458.1  transforming acidic coiled-coil-containing protein 3 isoform X3

    4. XM_039092209.2 → XP_038948137.1  transforming acidic coiled-coil-containing protein 3 isoform X4

      Conserved Domains (1) summary
      NF033804
      Location:261 → 389
      Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin
    Nucleotide Protein Strain
    Heading Accession and Version

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