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    CD200R1 CD200 receptor 1 [ Homo sapiens (human) ]

    Gene ID: 131450, updated on 2-Nov-2024

    Summary

    Official Symbol
    CD200R1provided by HGNC
    Official Full Name
    CD200 receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:24235
    See related
    Ensembl:ENSG00000163606 MIM:607546; AllianceGenome:HGNC:24235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OX2R; MOX2R; CD200R; HCRTR2
    Summary
    This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 4.6), placenta (RPKM 2.9) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CD200R1 in Genome Data Viewer
    Location:
    3q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (112921205..112975103, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (115642153..115696046, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112640052..112693950, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CD200R1L antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112543386-112543886 Neighboring gene CD200 receptor 1 like Neighboring gene ReSE screen-validated silencer GRCh37_chr3:112563646-112563805 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112590118-112590618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112603434-112604024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112604025-112604615 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:112612841-112614040 Neighboring gene CD200R1 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112709373-112710000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14605 Neighboring gene GTP binding protein 8 Neighboring gene NEPRO antisense RNA 1 Neighboring gene nucleolus and neural progenitor protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glycosylated region protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables immunoglobulin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Fc receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heterotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of macrophage migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cell surface glycoprotein CD200 receptor 1
    Names
    CD200 cell surface glycoprotein receptor
    MOX2 receptor
    cell surface glycoprotein OX2 receptor 1
    cell surface glycoprotein receptor CD200

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138806.4NP_620161.1  cell surface glycoprotein CD200 receptor 1 isoform a precursor

      See identical proteins and their annotated locations for NP_620161.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript variant and encodes the longest isoform (a).
      Source sequence(s)
      AC074044, AF495380, AK126349, AY358910
      Consensus CDS
      CCDS2969.1
      UniProtKB/Swiss-Prot
      B3KWZ9, E9PCM9, Q52LJ7, Q6IS95, Q6UW94, Q6WHB8, Q8TD44, Q8TD45, Q8TD46, Q8TD52
      UniProtKB/TrEMBL
      B7ZKV2
      Related
      ENSP00000311035.3, ENST00000308611.8
      Conserved Domains (1) summary
      cl11960
      Location:188257
      Ig; Immunoglobulin domain
    2. NM_138939.3NP_620385.1  cell surface glycoprotein CD200 receptor 1 isoform b precursor

      See identical proteins and their annotated locations for NP_620385.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the coding region, compared to variant 1. This results in a frameshift and early stop codon, as well as loss of an immunoglobulin and transmembrane domain in the protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC074044, AF497549, AK126349
      Consensus CDS
      CCDS46889.1
      UniProtKB/Swiss-Prot
      Q8TD46
      Related
      ENSP00000405733.2, ENST00000440122.6
    3. NM_138940.3NP_620386.1  cell surface glycoprotein CD200 receptor 1 isoform c precursor

      See identical proteins and their annotated locations for NP_620386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the coding region, compared to variant 1. This results in a frameshift and early stop codon, as well as loss of an immunoglobulin and transmembrane domain in the protein (isoform c), compared to isoform a.
      Source sequence(s)
      AC074044, AF497550, AK126349
      Consensus CDS
      CCDS54623.1
      UniProtKB/Swiss-Prot
      Q8TD46
      Related
      ENSP00000418801.1, ENST00000490004.1
    4. NM_170780.3NP_740750.1  cell surface glycoprotein CD200 receptor 1 isoform d precursor

      See identical proteins and their annotated locations for NP_740750.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) utilizes an alternate splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform d), compared to isoform a.
      Source sequence(s)
      AC074044, AF497548, AK126349
      Consensus CDS
      CCDS2970.1
      UniProtKB/TrEMBL
      B7ZKV2
      Related
      ENSP00000418928.1, ENST00000471858.5
      Conserved Domains (2) summary
      cd00096
      Location:4449
      Ig; Ig strand A [structural motif]
      cl11960
      Location:44150
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      112921205..112975103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      115642153..115696046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)