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    TNFAIP8 TNF alpha induced protein 8 [ Homo sapiens (human) ]

    Gene ID: 25816, updated on 28-Oct-2024

    Summary

    Official Symbol
    TNFAIP8provided by HGNC
    Official Full Name
    TNF alpha induced protein 8provided by HGNC
    Primary source
    HGNC:HGNC:17260
    See related
    Ensembl:ENSG00000145779 MIM:612111; AllianceGenome:HGNC:17260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13
    Summary
    Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in lymph node (RPKM 31.1), fat (RPKM 24.0) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TNFAIP8 in Genome Data Viewer
    Location:
    5q23.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (119268759..119399688)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (119789607..119920525)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (118604454..118735383)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Dmx like 1 Neighboring gene RNA, U6 small nuclear 701, pseudogene Neighboring gene microRNA 5706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:118591447-118592003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:118609555-118610054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22969 Neighboring gene RNA, 7SL, cytoplasmic 174, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:118664591-118665278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22975 Neighboring gene uncharacterized LOC102723444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16265 Neighboring gene Sharpr-MPRA regulatory region 6110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22983 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:118726761-118726918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22986 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:118737716-118738284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:118740092-118740592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22987 Neighboring gene Sharpr-MPRA regulatory region 10011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22989 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:118794469-118795121 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:118797267-118797484 Neighboring gene RNA, 5S ribosomal pseudogene 190 Neighboring gene uncharacterized LOC124901215 Neighboring gene hydroxysteroid 17-beta dehydrogenase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of tumor necrosis factor, alpha-induced protein 8 (TNFAIP8) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor alpha-induced protein 8
    Names
    NF-kappa-B-inducible DED-containing protein
    TNF-induced protein GG2-1
    head and neck tumor and metastasis-related protein
    tumor necrosis factor, alpha induced protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077654.3NP_001071122.1  tumor necrosis factor alpha-induced protein 8 isoform b

      See identical proteins and their annotated locations for NP_001071122.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5'-terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC035144, BC007014, BP274520, CB241243
      Consensus CDS
      CCDS47257.1
      UniProtKB/TrEMBL
      B3KUI2
      Related
      ENSP00000274456.6, ENST00000274456.6
      Conserved Domains (1) summary
      pfam05527
      Location:7185
      DUF758; Domain of unknown function (DUF758)
    2. NM_001286813.2NP_001273742.1  tumor necrosis factor alpha-induced protein 8 isoform a

      See identical proteins and their annotated locations for NP_001273742.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
      Source sequence(s)
      AC035144, AK097284, BC007014, CB241243
      Consensus CDS
      CCDS47258.1
      UniProtKB/Swiss-Prot
      B3KMH1, B3KMI2, B7Z713, O95379, Q9P1Q1, Q9UER5, Q9UP47
      UniProtKB/TrEMBL
      B3KUI2
      Related
      ENSP00000421848.1, ENST00000503646.1
      Conserved Domains (1) summary
      pfam05527
      Location:17195
      DUF758; Domain of unknown function (DUF758)
    3. NM_001286814.1NP_001273743.1  tumor necrosis factor alpha-induced protein 8 isoform c

      See identical proteins and their annotated locations for NP_001273743.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5'-terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a longer and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK301281, BC007014, CB241243, DC391074
      Consensus CDS
      CCDS68933.1
      UniProtKB/TrEMBL
      B3KUI2
      Related
      ENSP00000427424.1, ENST00000513374.1
      Conserved Domains (1) summary
      pfam05527
      Location:29207
      DUF758; Domain of unknown function (DUF758)
    4. NM_001286815.2NP_001273744.1  tumor necrosis factor alpha-induced protein 8 isoform d

      See identical proteins and their annotated locations for NP_001273744.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
      Source sequence(s)
      AC035144, BC007014, BP274520, CB241243, DB114867
      UniProtKB/TrEMBL
      B3KUI2
      Conserved Domains (1) summary
      pfam05527
      Location:1163
      DUF758; Domain of unknown function (DUF758)
    5. NM_001286817.2NP_001273746.1  tumor necrosis factor alpha-induced protein 8 isoform d

      See identical proteins and their annotated locations for NP_001273746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
      Source sequence(s)
      AC035144, BC007014, BP274520, CB241243, DB124282
      UniProtKB/TrEMBL
      B3KUI2
      Conserved Domains (1) summary
      pfam05527
      Location:1163
      DUF758; Domain of unknown function (DUF758)
    6. NM_014350.4NP_055165.2  tumor necrosis factor alpha-induced protein 8 isoform a

      See identical proteins and their annotated locations for NP_055165.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Both variant 1 and 3 encode the same isoform.
      Source sequence(s)
      AC035144, BC007014, CB241243
      Consensus CDS
      CCDS47258.1
      UniProtKB/Swiss-Prot
      B3KMH1, B3KMI2, B7Z713, O95379, Q9P1Q1, Q9UER5, Q9UP47
      UniProtKB/TrEMBL
      B3KUI2
      Related
      ENSP00000422245.1, ENST00000504771.3
      Conserved Domains (1) summary
      pfam05527
      Location:17195
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      119268759..119399688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009328.2XP_016864817.1  tumor necrosis factor alpha-induced protein 8 isoform X2

      UniProtKB/TrEMBL
      B3KUI2
      Conserved Domains (1) summary
      pfam05527
      Location:1163
      DUF758; Domain of unknown function (DUF758)
    2. XM_047417082.1XP_047273038.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    3. XM_017009327.2XP_016864816.1  tumor necrosis factor alpha-induced protein 8 isoform X1

      UniProtKB/TrEMBL
      B3KUI2
    4. XM_047417081.1XP_047273037.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      119789607..119920525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352324.1XP_054208299.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    2. XM_054352326.1XP_054208301.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    3. XM_054352323.1XP_054208298.1  tumor necrosis factor alpha-induced protein 8 isoform X1

    4. XM_054352325.1XP_054208300.1  tumor necrosis factor alpha-induced protein 8 isoform X2