FASTK Fas activated serine/threonine kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: FASTKprovided by HGNC
Official Full Name: Fas activated serine/threonine kinaseprovided by HGNC
Primary source: HGNC:HGNC:24676
See related: Ensembl:ENSG00000164896 MIM:606965; AllianceGenome:HGNC:24676
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FAST
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in duodenum (RPKM 16.4), prostate (RPKM 16.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q36.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (151076624..151080809, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (152249742..152253931, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (150773711..150777896, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Accuracy of FAST in detecting intraabdominal bleeding in major trauma with pelvic and/or acetabular fractures: a retrospective cohort study.
Title: Accuracy of FAST in detecting intraabdominal bleeding in major trauma with pelvic and/or acetabular fractures: a retrospective cohort study.
Systematic Analysis of FASTK Gene Family Alterations in Cancer.
Title: Systematic Analysis of FASTK Gene Family Alterations in Cancer.
FASTK binds at multiple sites along the ND6 mRNA and its precursors and cooperates with the mitochondrial degradosome to ensure regulated ND6 mRNA biogenesis.
Title: A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.
MIR-106a-5p functions as a tumor suppressor during the development of astrocytomas by targeting FASTK.
Title: miR-106a-5p inhibits the proliferation and migration of astrocytoma cells and promotes apoptosis by targeting FASTK.
FAST expression on lung cells of hematopoietic origin is crucial in mediating lipopolysaccharide-induced neutrophil migration to the lung in transgenic FAST-deficient mice compared with wild type controls.
Title: Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Nuclear FAST can regulate the splicing of FGFR2 transcripts.
Title: Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing.
FAST K synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing
Title: Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing.
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1 regulated changes in protein expression.
Title: FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S469E (e-PCR)
- UniSTS:38419

MARC_8201-8202:996688395:1 (e-PCR)
- UniSTS:269926

RH71298 (e-PCR)
- UniSTS:9183

STS-X62137 (e-PCR)
- UniSTS:46057

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Fas-activated serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in mitochondrial RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of RNA splicing	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial mRNA stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	TAS Traceable Author Statement more info
located_in mitochondrion	HTP more info	PubMed
is_active_in ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fas-activated serine/threonine kinase

Names: FAST kinase

NP_001245390.1

EC 2.7.11.1

EC 2.7.11.8

NP_006703.1

EC 2.7.11.1

EC 2.7.11.8

NP_148936.2

EC 2.7.11.1

EC 2.7.11.8

XP_005249989.1

EC 2.7.11.1

EC 2.7.11.8

XP_011514063.1

EC 2.7.11.1

EC 2.7.11.8

XP_011514064.1

EC 2.7.11.1

EC 2.7.11.8

XP_011514065.1

EC 2.7.11.1

EC 2.7.11.8

XP_016867194.1

EC 2.7.11.1

EC 2.7.11.8

XP_047275784.1

EC 2.7.11.1

EC 2.7.11.8

XP_047275786.1

EC 2.7.11.1

EC 2.7.11.8

XP_047275787.1

EC 2.7.11.1

EC 2.7.11.8

XP_054213124.1

EC 2.7.11.1

EC 2.7.11.8

XP_054213125.1

EC 2.7.11.1

EC 2.7.11.8

XP_054213126.1

EC 2.7.11.1

EC 2.7.11.8

XP_054213127.1

EC 2.7.11.1

EC 2.7.11.8

XP_054213128.1

EC 2.7.11.1

EC 2.7.11.8

XP_054213129.1

EC 2.7.11.1

EC 2.7.11.8

XP_054213130.1

EC 2.7.11.1

EC 2.7.11.8

XP_054213131.1

EC 2.7.11.1

EC 2.7.11.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001258461.2 → NP_001245390.1 fas-activated serine/threonine kinase isoform 5

See identical proteins and their annotated locations for NP_001245390.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.

Source sequence(s)

AB209783, AC010973, DA253544

Consensus CDS

CCDS59088.1

UniProtKB/TrEMBL

Q53FZ9

Related

ENSP00000418516.1, ENST00000482571.2

Conserved Domains (3) summary

smart00952
Location:457 → 509

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:250 → 316

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:328 → 417

FAST_2; FAST kinase-like protein, subdomain 2
NM_006712.5 → NP_006703.1 fas-activated serine/threonine kinase isoform 1

See identical proteins and their annotated locations for NP_006703.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

BC011770, BU682096, DA253544

Consensus CDS

CCDS5918.1

UniProtKB/Swiss-Prot

A8K867, F8VTW9, Q14296, Q59EM8, Q8IVA0

UniProtKB/TrEMBL

A0A090N8Z7, Q53FZ9

Related

ENSP00000297532.6, ENST00000297532.11

Conserved Domains (3) summary

smart00952
Location:484 → 536

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:278 → 343

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:358 → 443

FAST_2; FAST kinase-like protein, subdomain 2
NM_033015.4 → NP_148936.2 fas-activated serine/threonine kinase isoform 4

See identical proteins and their annotated locations for NP_148936.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC010973, BC039026

Consensus CDS

CCDS5919.1

UniProtKB/TrEMBL

A0A090N8I0

Related

ENSP00000324817.6, ENST00000353841.6

Conserved Domains (3) summary

smart00952
Location:343 → 395

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:137 → 202

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:217 → 302

FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

151076624..151080809 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011515763.2 → XP_011514065.1 fas-activated serine/threonine kinase isoform X6

See identical proteins and their annotated locations for XP_011514065.1

Conserved Domains (3) summary

smart00952
Location:316 → 368

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:110 → 175

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:190 → 275

FAST_2; FAST kinase-like protein, subdomain 2
XM_047419831.1 → XP_047275787.1 fas-activated serine/threonine kinase isoform X8
XM_017011705.3 → XP_016867194.1 fas-activated serine/threonine kinase isoform X7
XM_047419828.1 → XP_047275784.1 fas-activated serine/threonine kinase isoform X3
XM_011515762.4 → XP_011514064.1 fas-activated serine/threonine kinase isoform X4

UniProtKB/TrEMBL

Q9BWD7

Conserved Domains (2) summary

pfam06743
Location:278 → 343

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:358 → 428

FAST_2; FAST kinase-like protein, subdomain 2
XM_011515761.4 → XP_011514063.1 fas-activated serine/threonine kinase isoform X2

See identical proteins and their annotated locations for XP_011514063.1

UniProtKB/TrEMBL

Q9BWD7

Conserved Domains (2) summary

pfam06743
Location:278 → 343

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:358 → 443

FAST_2; FAST kinase-like protein, subdomain 2
XM_047419830.1 → XP_047275786.1 fas-activated serine/threonine kinase isoform X5
XM_005249932.2 → XP_005249989.1 fas-activated serine/threonine kinase isoform X1

See identical proteins and their annotated locations for XP_005249989.1

UniProtKB/TrEMBL

Q53FZ9

Conserved Domains (3) summary

smart00952
Location:450 → 502

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:244 → 309

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:324 → 409

FAST_2; FAST kinase-like protein, subdomain 2

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

152249742..152253931 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054357153.1 → XP_054213128.1 fas-activated serine/threonine kinase isoform X5
XM_054357154.1 → XP_054213129.1 fas-activated serine/threonine kinase isoform X6
XM_054357156.1 → XP_054213131.1 fas-activated serine/threonine kinase isoform X8
XM_054357155.1 → XP_054213130.1 fas-activated serine/threonine kinase isoform X7
XM_054357151.1 → XP_054213126.1 fas-activated serine/threonine kinase isoform X3
XM_054357152.1 → XP_054213127.1 fas-activated serine/threonine kinase isoform X4
XM_054357150.1 → XP_054213125.1 fas-activated serine/threonine kinase isoform X2
XM_054357149.1 → XP_054213124.1 fas-activated serine/threonine kinase isoform X1