RBM15 RNA binding motif protein 15 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RBM15provided by HGNC
Official Full Name: RNA binding motif protein 15provided by HGNC
Primary source: HGNC:HGNC:14959
See related: Ensembl:ENSG00000162775 MIM:606077; AllianceGenome:HGNC:14959
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OTT; OTT1; SPEN
Summary: Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Expression: Broad expression in bone marrow (RPKM 6.3), testis (RPKM 2.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p13.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (110339377..110346677)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (110354432..110361733)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (110881999..110889299)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBM15 Promotes High Glucose-Induced Lens Epithelial Cell Injury by Inducing PRNP N6-Methyladenine Modification During Diabetic Cataract.
Title: RBM15 Promotes High Glucose-Induced Lens Epithelial Cell Injury by Inducing PRNP N6-Methyladenine Modification During Diabetic Cataract.
Identification of RBM15 as a prognostic biomarker in prostate cancer involving the regulation of prognostic m6A-related lncRNAs.
Title: Identification of RBM15 as a prognostic biomarker in prostate cancer involving the regulation of prognostic m6A-related lncRNAs.
The m[6]A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism.
Title: The m(6)A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism.
RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of EZH2 Drives the Epithelial-Mesenchymal Transition of Cervical Cancer.
Title: RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of EZH2 Drives the Epithelial-Mesenchymal Transition of Cervical Cancer.
Regulatory mechanism of RNA binding motif protein 15-mediated N[6] methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells.
Title: Regulatory mechanism of RNA binding motif protein 15-mediated N(6) methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells.
RBM15-mediating MDR1 mRNA m[6]A methylation regulated by the TGF-beta signaling pathway in paclitaxel-resistant ovarian cancer.
Title: RBM15‑mediating MDR1 mRNA m(6)A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer.
RBM15 m[6] A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling.
Title: RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling.
Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer.
Title: Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer.
RBM15 silencing promotes ferroptosis by regulating the TGF-beta/Smad2 pathway in lung cancer.
Title: RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer.
Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA.
Title: Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	NXF1 upregulates the RBM15-mediated Gag expression from pNLgag-RTE, suggesting cooperation between RBM15 and NXF1	PubMed
Rev	rev	HIV-1 Rev interacting protein, RNA binding motif protein 15 (RBM15), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with RBM15 is increased by RRE	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103780 (e-PCR)
- UniSTS:98105

RH102340 (e-PCR)
- UniSTS:96674

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in branching involved in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dosage compensation by inactivation of X chromosome	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in placenta blood vessel development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription of Notch receptor target	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of megakaryocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in spleen development	IEA Inferred from Electronic Annotation more info
involved_in thrombopoietin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA N6-methyladenosine methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding protein 15

Names: one twenty two protein; one twenty-two; one-twenty two protein 1; putative RNA-binding protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201545.2 → NP_001188474.1 RNA-binding protein 15 isoform 2

See identical proteins and their annotated locations for NP_001188474.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AI863760, AL355488, BC006397, BC098140

Consensus CDS

CCDS59198.1

UniProtKB/TrEMBL

A0A499FJY3

Related

ENSP00000473552.3, ENST00000487146.8

Conserved Domains (5) summary

TIGR01622
Location:624 → 736

SF-CC1; splicing factor, CC1-like family

pfam07744
Location:781 → 954

SPOC; SPOC domain

cd12553
Location:169 → 251

RRM1_RBM15; RNA recognition motif 1 (RRM1) found in vertebrate RNA binding motif protein 15 (RBM15)

cd12555
Location:367 → 453

RRM2_RBM15; RNA recognition motif 2 (RRM2) found in vertebrate RNA binding motif protein 15 (RBM15)

cd12557
Location:456 → 528

RRM3_RBM15; RNA recognition motif 3 (RRM3) found in vertebrate RNA binding motif protein 15 (RBM15)
NM_022768.5 → NP_073605.4 RNA-binding protein 15 isoform 1

See identical proteins and their annotated locations for NP_073605.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AL355488, BC042587, BC047479, BC062316

Consensus CDS

CCDS822.1

UniProtKB/Swiss-Prot

A1A693, Q3ZB86, Q4V760, Q5D058, Q5T613, Q86VW9, Q96PE4, Q96SC9, Q96SD0, Q96T37, Q96T38, Q9BRA5, Q9H6R8, Q9H9Y0

UniProtKB/TrEMBL

A0A087WWP4

Related

ENSP00000358799.3, ENST00000369784.9

Conserved Domains (5) summary

TIGR01622
Location:624 → 736

SF-CC1; splicing factor, CC1-like family

pfam07744
Location:781 → 954

SPOC; SPOC domain

cd12553
Location:169 → 251

RRM1_RBM15; RNA recognition motif 1 (RRM1) found in vertebrate RNA binding motif protein 15 (RBM15)

cd12555
Location:367 → 453

RRM2_RBM15; RNA recognition motif 2 (RRM2) found in vertebrate RNA binding motif protein 15 (RBM15)

cd12557
Location:456 → 528

RRM3_RBM15; RNA recognition motif 3 (RRM3) found in vertebrate RNA binding motif protein 15 (RBM15)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

110339377..110346677

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

110354432..110361733

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_014092.1: Suppressed sequence

Description

NM_014092.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.