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    Apoo apolipoprotein O [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363474, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Apooprovided by RGD
    Official Full Name
    apolipoprotein Oprovided by RGD
    Primary source
    RGD:1565289
    See related
    EnsemblRapid:ENSRNOG00000046918 AllianceGenome:RGD:1565289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565289
    Summary
    Predicted to be involved in cristae formation. Predicted to be located in several cellular components, including Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Predicted to be part of MICOS complex. Orthologous to human APOO (apolipoprotein O). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 280.3), Muscle (RPKM 213.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Apoo in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (63151736..63256696)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (59157971..59262940)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (63521033..63625134)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 21, pseudogene 1 Neighboring gene similar to human chromosome X open reading frame 58 Neighboring gene RWD domain containing 4, pseudogene 1 Neighboring gene uncharacterized LOC108349225 Neighboring gene small nucleolar RNA, H/ACA box 11E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart. Turkieh A, et al. J Clin Invest, 2014 May. PMID 24743151, Free PMC Article
    2. The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions. Koob S, et al. Biochim Biophys Acta, 2015 Jul. PMID 25764979
    3. Mitofilin complexes: conserved organizers of mitochondrial membrane architecture. Zerbes RM, et al. Biol Chem, 2012 Nov. PMID 23109542
    4. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. Ott C, et al. PLoS One, 2015. PMID 25781180, Free PMC Article
    5. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Guarani V, et al. Elife, 2015 May 21. PMID 25997101, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MICOS complex subunit MIC26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199178.1 → NP_001186107.1  MICOS complex subunit MIC26

      Status: VALIDATED

      Source sequence(s)
      CB616794, DV726817, FM122174
      UniProtKB/TrEMBL
      A0A8I6A768, M0R7V3
      Related
      ENSRNOP00000065539.2, ENSRNOT00000071590.5
      Conserved Domains (1) summary
      pfam09769
      Location:41 → 177
      ApoO; Apolipoprotein O

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      63151736..63256696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099894.2 → XP_038955822.1  MICOS complex subunit MIC26 isoform X2

      Conserved Domains (1) summary
      pfam09769
      Location:54 → 80
      ApoO; Apolipoprotein O

    2. XM_039099895.1 → XP_038955823.1  MICOS complex subunit MIC26 isoform X3

      Conserved Domains (1) summary
      pfam09769
      Location:54 → 86
      ApoO; Apolipoprotein O

    3. XM_039099893.2 → XP_038955821.1  MICOS complex subunit MIC26 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A768, A6IQ10
      Related
      ENSRNOP00000089406.2, ENSRNOT00000098632.2
      Conserved Domains (1) summary
      pfam09769
      Location:20 → 143
      ApoO; Apolipoprotein O
    Nucleotide Protein Strain
    Heading Accession and Version

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