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    UNC13B unc-13 homolog B [ Homo sapiens (human) ]

    Gene ID: 10497, updated on 2-Nov-2024

    Summary

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    Official Symbol
    UNC13Bprovided by HGNC
    Official Full Name
    unc-13 homolog Bprovided by HGNC
    Primary source
    HGNC:HGNC:12566
    See related
    Ensembl:ENSG00000198722 MIM:605836; AllianceGenome:HGNC:12566
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNC13; MUNC13; Unc13h2; munc13-2
    Summary
    This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lung (RPKM 12.8), kidney (RPKM 6.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UNC13B in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (35162009..35405335)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (35181209..35424479)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35162006..35405332)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902147 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:35157812-35158365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19863 Neighboring gene zinc finger protein 492 pseudogene Neighboring gene Sharpr-MPRA regulatory region 3537 Neighboring gene MPRA-validated peak7230 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:35327315-35328514 Neighboring gene Sharpr-MPRA regulatory region 14419 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr9:35373268-35373820 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:35397379-35398578 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:35403221-35404420 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:35405745-35406290 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:35406291-35406836 Neighboring gene ATPase phospholipid transporting 8B5, pseudogene Neighboring gene zinc finger AN1-type containing 6 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:35481926-35482160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19864 Neighboring gene uncharacterized LOC105376026 Neighboring gene RUN and SH3 domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural insights into calmodulin/Munc13 interaction. Herbst S, et al. Biol Chem, 2014 Jul. PMID 24854537
    2. Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release. Grushin K, et al. Proc Natl Acad Sci U S A, 2022 Feb 15. PMID 35135883, Free PMC Article
    3. Rare UNC13B variations and risk of schizophrenia: Whole-exome sequencing in a multiplex family and follow-up resequencing and a case-control study. Egawa J, et al. Am J Med Genet B Neuropsychiatr Genet, 2016 Sep. PMID 26990377
    4. G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes. Trégouet DA, et al. Diabetes, 2008 Oct. PMID 18633107, Free PMC Article
    5. The Association of UNC13B Gene Polymorphisms and Diabetic Kidney Disease in a Chinese Han Population. Wang Y, et al. Med Sci Monit, 2019 Nov 12. PMID 31713534, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release.
      Title: Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release.
    2. UNC13B variants associated with partial epilepsy with favourable outcome.
      Title: UNC13B variants associated with partial epilepsy with favourable outcome.
    3. TRPC6 exocytosis by targeting to the C1 domain of Munc13-2.
      Title: Munc13 mediates klotho-inhibitable diacylglycerol-stimulated exocytotic insertion of pre-docked TRPC6 vesicles.
    4. There were no significant differences in the distribution of allele or genotype frequencies in the five UNC13B SNP markers (rs13293564, rs17360668, rs10114937, rs661712, and rs2281999) between the Diabetic Kidney Disease group and control group of patients with type 2 diabetes mellitus .
      Title: The Association of UNC13B Gene Polymorphisms and Diabetic Kidney Disease in a Chinese Han Population.
    5. Abnormal splicing mutation in UNC13B was identified in the patient with bipolar disorder.
      Title: De novo UNC13B mutation identified in a bipolar disorder patient increases a rare exon-skipping variant.
    6. Assisted by NSF/alpha-SNAP, syntaxin-1 escapes tomosyn arrest and assembles into the Munc18-1/syntaxin-1 complex. Munc13-1 then catalyzes the transit of syntaxin-1 from the Munc18-1/syntaxin-1 complex to the SNARE complex
      Title: Tomosyn guides SNARE complex formation in coordination with Munc18 and Munc13.
    7. A rare missense variation (V1525M) in UNC13B was identified by WES in the multiplex family; this variation was present in five of six affected individuals, but not in eight unaffected individuals or one individual of unknown disease status. Resequencing UNC13B coding regions identified five rare missense variations (T103M, M813T, P1349T, I1362T, and V1525M).
      Title: Rare UNC13B variations and risk of schizophrenia: Whole-exome sequencing in a multiplex family and follow-up resequencing and a case-control study.
    8. The 1-5-8-26 CaM binding motif discovered in Munc13-1 cannot be induced in the classical CaM target skMLCK, indicating unique features of the Munc13 CaM binding motif.
      Title: Structural insights into calmodulin/Munc13 interaction.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. mechanistic basis for high glucose-induced protein secretion is through interaction of munc13 and rab34, indicating a potentially critical role for this newly described pathway in the pathogenesis of DN.
      Title: Rab34 and its effector munc13-2 constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC133279, MGC133280

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables diacylglycerol binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables syntaxin-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosomal vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dense core granule priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal dense core vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of inhibitory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of synaptic vesicle priming ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in presynaptic dense core vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in presynaptic active zone TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynaptic active zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in terminal bouton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein unc-13 homolog B
    Names
    homolog of rat Munc13 (diacylglycerol-binding)
    unc-13-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033014.1 RefSeqGene

      Range
      5018..248344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330653.3 → NP_001317582.1  protein unc-13 homolog B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL160274, AL353795, AL354669
      Consensus CDS
      CCDS83361.1
      UniProtKB/TrEMBL
      B1AM27
      Related
      ENSP00000479261.1, ENST00000619578.4
      Conserved Domains (6) summary
      cd04027
      Location:600 → 726
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08394
      Location:1 → 127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1458 → 1577
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:478 → 527
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:918 → 1022
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1265 → 1401
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    2. NM_001371186.2 → NP_001358115.1  protein unc-13 homolog B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL160274, AL353795, AL354669
      UniProtKB/TrEMBL
      Q4LE73
      Conserved Domains (6) summary
      cd04027
      Location:600 → 726
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08394
      Location:1 → 127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1438 → 1557
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:478 → 527
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:918 → 1019
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1264 → 1400
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    3. NM_001371187.2 → NP_001358116.1  protein unc-13 homolog B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL160274
      Consensus CDS
      CCDS94405.1
      UniProtKB/TrEMBL
      A0A1B0GVW8
      Related
      ENSP00000490683.1, ENST00000636694.1
      Conserved Domains (5) summary
      cd04027
      Location:980 → 1106
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1838 → 1957
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:858 → 907
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:1298 → 1400
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1645 → 1781
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    4. NM_001371188.2 → NP_001358117.1  protein unc-13 homolog B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL160274
      UniProtKB/TrEMBL
      I6L9J0
      Related
      ENST00000637271.1
      Conserved Domains (5) summary
      cd04027
      Location:230 → 356
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1069 → 1188
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:108 → 157
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:548 → 650
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:895 → 1031
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    5. NM_001371189.2 → NP_001358118.1  protein unc-13 homolog B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL160274, AL353795, AL354669
      Consensus CDS
      CCDS94404.1
      UniProtKB/TrEMBL
      A0A1B0GUS7
      Related
      ENSP00000490228.1, ENST00000635942.2
      Conserved Domains (6) summary
      cd04027
      Location:3349 → 3475
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08394
      Location:1 → 127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:4188 → 4307
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:3227 → 3276
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:3667 → 3769
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:4014 → 4150
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    6. NM_001387551.1 → NP_001374480.1  protein unc-13 homolog B isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL160274, AL353795, AL354669
      UniProtKB/TrEMBL
      B1AM27
      Conserved Domains (6) summary
      cd04027
      Location:612 → 738
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08394
      Location:1 → 127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1451 → 1570
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      pfam06292
      Location:930 → 1034
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1277 → 1413
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
      cd20859
      Location:471 → 552
      C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins

    7. NM_001387553.1 → NP_001374482.1  protein unc-13 homolog B isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL160274, AL354669
      UniProtKB/TrEMBL
      Q4LE73
      Conserved Domains (6) summary
      cd04027
      Location:551 → 677
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1390 → 1509
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      pfam06292
      Location:869 → 973
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1216 → 1352
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
      cd20859
      Location:410 → 491
      C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
      cl14603
      Location:1 → 78
      C2; C2 domain

    8. NM_001387554.1 → NP_001374483.1  protein unc-13 homolog B isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL160274, AL354669
      UniProtKB/TrEMBL
      Q4LE73
      Conserved Domains (6) summary
      cd04027
      Location:551 → 677
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1389 → 1508
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      pfam06292
      Location:869 → 972
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1215 → 1351
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
      cd20859
      Location:410 → 491
      C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
      cl14603
      Location:1 → 78
      C2; C2 domain

    9. NM_001387555.1 → NP_001374484.1  protein unc-13 homolog B isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL160274
      Conserved Domains (5) summary
      cd04027
      Location:980 → 1106
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1837 → 1956
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      pfam06292
      Location:1298 → 1401
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1644 → 1780
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
      cd20859
      Location:839 → 920
      C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins

    10. NM_006377.6 → NP_006368.3  protein unc-13 homolog B isoform 1

      See identical proteins and their annotated locations for NP_006368.3

      Status: REVIEWED

      Source sequence(s)
      AL160274, AL353795, AL354669
      Consensus CDS
      CCDS6579.1
      UniProtKB/Swiss-Prot
      O14795, Q2NKJ5, Q5VYM8
      UniProtKB/TrEMBL
      Q4LE73
      Related
      ENSP00000367756.3, ENST00000378495.7
      Conserved Domains (6) summary
      cd04027
      Location:600 → 726
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08394
      Location:1 → 127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1439 → 1558
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:478 → 527
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:918 → 1022
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1265 → 1401
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    RNA

    1. NR_170667.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL160274, AL353795, AL354669

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      35162009..35405335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422602.1 → XP_047278558.1  protein unc-13 homolog B isoform X3

    2. XM_047422603.1 → XP_047278559.1  protein unc-13 homolog B isoform X4

    3. XM_047422604.1 → XP_047278560.1  protein unc-13 homolog B isoform X5

    4. XM_011517686.3 → XP_011515988.1  protein unc-13 homolog B isoform X6

      UniProtKB/TrEMBL
      I6L9J0
      Related
      ENSP00000484432.1, ENST00000617908.4
      Conserved Domains (5) summary
      cd04027
      Location:230 → 356
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1088 → 1207
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:108 → 157
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:548 → 652
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:895 → 1031
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    5. XM_047422605.1 → XP_047278561.1  protein unc-13 homolog B isoform X7

    6. XM_047422600.1 → XP_047278556.1  protein unc-13 homolog B isoform X1

    7. XM_047422601.1 → XP_047278557.1  protein unc-13 homolog B isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      35181209..35424479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361711.1 → XP_054217686.1  protein unc-13 homolog B isoform X3

    2. XM_054361712.1 → XP_054217687.1  protein unc-13 homolog B isoform X4

    3. XM_054361713.1 → XP_054217688.1  protein unc-13 homolog B isoform X5

    4. XM_054361714.1 → XP_054217689.1  protein unc-13 homolog B isoform X6

    5. XM_054361715.1 → XP_054217690.1  protein unc-13 homolog B isoform X7

    6. XM_054361709.1 → XP_054217684.1  protein unc-13 homolog B isoform X1

    7. XM_054361710.1 → XP_054217685.1  protein unc-13 homolog B isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14795.2 GenPept UniProtKB/Swiss-Prot:O14795

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