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    SERPINB10 serpin family B member 10 [ Homo sapiens (human) ]

    Gene ID: 5273, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SERPINB10provided by HGNC
    Official Full Name
    serpin family B member 10provided by HGNC
    Primary source
    HGNC:HGNC:8942
    See related
    Ensembl:ENSG00000242550 MIM:602058; AllianceGenome:HGNC:8942
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PI10; PI-10
    Summary
    This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. [provided by RefSeq, Dec 2015]
    Expression
    Restricted expression toward bone marrow (RPKM 23.0) See more
    Orthologs
    mouse all
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    Genomic context

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    See SERPINB10 in Genome Data Viewer
    Location:
    18q22.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (63907958..63936111)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (64113032..64141170)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61575192..61603345)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene serpin family B member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13469 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:61536385-61537584 Neighboring gene uncharacterized LOC124904356 Neighboring gene serpin family B member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:61607430-61607930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9531 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13470 Neighboring gene uncharacterized LOC105372165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9532 Neighboring gene Sharpr-MPRA regulatory region 9998 Neighboring gene histocompatibility minor serpin domain containing Neighboring gene serpin family B member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Increased SERPINB10 Expression in Induced Sputum Was Associated with Airway Type 2 Inflammation in Asthma. Zong W, et al. Int Arch Allergy Immunol, 2022. PMID 35526531
    2. Increased Expression of SERPINB10 Associated with Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps. Deng Z, et al. Dis Markers, 2022. PMID 36398030, Free PMC Article
    3. SerpinB10, a Serine Protease Inhibitor, Is Implicated in UV-Induced Cellular Response. Majoros H, et al. Int J Mol Sci, 2021 Aug 7. PMID 34445206, Free PMC Article
    4. Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow. Riewald M, et al. J Biol Chem, 1995 Nov 10. PMID 7592909
    5. Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10. Chuang TL, et al. J Biol Chem, 1999 Apr 16. PMID 10196205

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased Expression of SERPINB10 Associated with Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps.
      Title: Increased Expression of SERPINB10 Associated with Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps.
    2. Increased SERPINB10 Expression in Induced Sputum Was Associated with Airway Type 2 Inflammation in Asthma.
      Title: Increased SERPINB10 Expression in Induced Sputum Was Associated with Airway Type 2 Inflammation in Asthma.
    3. SerpinB10, a Serine Protease Inhibitor, Is Implicated in UV-Induced Cellular Response.
      Title: SerpinB10, a Serine Protease Inhibitor, Is Implicated in UV-Induced Cellular Response.
    4. Epithelial SERPINB10 contributes to allergic airway eosinophilic inflammation, at least in part, by regulating the expression of periostin and CCL26.
      Title: Epithelial SERPINB10, a novel marker of airway eosinophilia in asthma, contributes to allergic airway inflammation.
    5. DGCR2, GPR44 and SerpinB10, found in beta cells, were negative in all other cell types within pancreas and exposed epitopes at the cell surface
      Title: Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates.
    6. Bomapin is a redox-sensitive nuclear serpin that augments proliferation or apoptosis of leukaemia cells, depending on growth factors availability.
      Title: Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Nucleotide variations in genes encoding plasminogen activator inhibitor-2 and serine proteinase inhibitor B10 associated with prostate cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    serpin B10
    Names
    bomapin
    peptidase inhibitor 10
    protease inhibitor 10 (ovalbumin type)
    protease inhibitor 10 (ovalbumin type, bomapin)
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10
    serpin peptidase inhibitor, clade B (ovalbumin), member 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005024.3 → NP_005015.1  serpin B10

      See identical proteins and their annotated locations for NP_005015.1

      Status: REVIEWED

      Source sequence(s)
      AA993220, AC009802, AC072051, AK314936, U35459
      Consensus CDS
      CCDS11990.1
      UniProtKB/Swiss-Prot
      P48595, Q4VAX4, Q4VAX7
      UniProtKB/TrEMBL
      Q4VAX6
      Related
      ENSP00000238508.3, ENST00000238508.8
      Conserved Domains (1) summary
      cd19569
      Location:1 → 397
      serpinB10_bomapin; serpin family B member 10, bomapin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      63907958..63936111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526027.2 → XP_011524329.1  serpin B10 isoform X1

      See identical proteins and their annotated locations for XP_011524329.1

      UniProtKB/Swiss-Prot
      P48595, Q4VAX4, Q4VAX7
      UniProtKB/TrEMBL
      Q4VAX6
      Conserved Domains (1) summary
      cd19569
      Location:1 → 397
      serpinB10_bomapin; serpin family B member 10, bomapin

    2. XM_017025793.2 → XP_016881282.1  serpin B10 isoform X2

      UniProtKB/TrEMBL
      Q4VAX6

    3. XM_011526028.1 → XP_011524330.1  serpin B10 isoform X3

      Conserved Domains (1) summary
      cl00137
      Location:1 → 268
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      64113032..64141170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318688.1 → XP_054174663.1  serpin B10 isoform X1

    2. XM_054318689.1 → XP_054174664.1  serpin B10 isoform X2

    3. XM_054318690.1 → XP_054174665.1  serpin B10 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48595.1 GenPept UniProtKB/Swiss-Prot:P48595

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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