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    POP7 ribonuclease P/MRP protein subunit POP7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852465, updated on 2-Nov-2024

    Summary

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    Official Symbol
    POP7
    Official Full Name
    ribonuclease P/MRP protein subunit POP7
    Primary source
    SGD:S000000371
    Locus tag
    YBR167C
    See related
    AllianceGenome:SGD:S000000371; FungiDB:YBR167C; VEuPathDB:YBR167C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPP2
    Summary
    Enables RNA binding activity. Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in RNA metabolic process. Part of nucleolar ribonuclease P complex; ribonuclease MRP complex; and telomerase holoenzyme complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See POP7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (571468..571890, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ubs1p Neighboring gene prephenate dehydrogenase (NADP(+)) Neighboring gene Pex32p Neighboring gene adenyl-nucleotide exchange factor SSE2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Eukaryotic ribonucleases P/MRP: the crystal structure of the P3 domain. Perederina A, et al. EMBO J, 2010 Feb 17. PMID 20075859, Free PMC Article
    2. Footprinting analysis of interactions between the largest eukaryotic RNase P/MRP protein Pop1 and RNase P/MRP RNA components. Fagerlund RD, et al. RNA, 2015 Sep. PMID 26135751, Free PMC Article
    3. Rpp2, an essential protein subunit of nuclear RNase P, is required for processing of precursor tRNAs and 35S precursor rRNA in Saccharomyces cerevisiae. Stolc V, et al. Proc Natl Acad Sci U S A, 1998 Jun 9. PMID 9618478, Free PMC Article
    4. Crystallization and preliminary X-ray diffraction analysis of the P3 RNA domain of yeast ribonuclease MRP in a complex with RNase P/MRP protein components Pop6 and Pop7. Perederina A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Jan 1. PMID 20057077, Free PMC Article
    5. Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P. Perederina A, et al. RNA Biol, 2023 Jan. PMID 37074161, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study reports that the Pop1, Pop6, and Pop7 proteins, known components of RNase P and RNase MRP, bind to yeast telomerase RNA and are essential constituents of the telomerase holoenzyme.
      Title: Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP.
    2. Crystal of Pop6 (18.2 kDa) and Pop7 (15.8 kDa) were obtained. They belonged to space group P4(2)22 (unit-cell parameters a = b = 127.2, c = 76.8 A, alpha = beta = gamma = 90 degrees ) and diffracted to 3.25 A resolution
      Title: Crystallization and preliminary X-ray diffraction analysis of the P3 RNA domain of yeast ribonuclease MRP in a complex with RNase P/MRP protein components Pop6 and Pop7.
    3. Footprint analysis of the interaction between the Pop6/7 heterodimer and the RNase mitochondrial RNA-processing RNA, combined with gel mobility assays, demonstrates that the Pop6/7 complex binds to a conserved region of the P3 domain.
      Title: Specific binding of a Pop6/Pop7 heterodimer to the P3 stem of the yeast RNase MRP and RNase P RNAs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribonuclease MRP activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonuclease MRP activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ribonuclease MRP activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to ribonuclease P activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonuclease P activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonuclease P activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribonuclease P activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intronic box C/D snoRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intronic box C/D snoRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA 5'-leader removal IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nucleolar ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleolar ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleolar ribonuclease P complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease MRP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonuclease MRP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of ribonuclease MRP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonuclease P/MRP protein subunit POP7
    NP_009726.3
    • Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      571468..571890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178515.3 → NP_009726.3  TPA: ribonuclease P/MRP protein subunit POP7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009726.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQG3, E9P8X7, P38291
      UniProtKB/TrEMBL
      A6ZLB0, B3LMZ1, B5VEC3, C7GUI2, D3UER2, G2W9H0, N1P9J0
      Conserved Domains (1) summary
      pfam12328
      Location:28 → 137
      Rpp20; Rpp20 subunit of nuclear RNase MRP and P
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38291.1

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