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    LINC02487 long intergenic non-protein coding RNA 2487 [ Homo sapiens (human) ]

    Gene ID: 441178, updated on 17-Sep-2024

    Summary

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    Official Symbol
    LINC02487provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 2487provided by HGNC
    Primary source
    HGNC:HGNC:53466
    See related
    Ensembl:ENSG00000203688 AllianceGenome:HGNC:53466
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Restricted expression toward esophagus (RPKM 19.4) See more
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    Genomic context

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    See LINC02487 in Genome Data Viewer
    Location:
    6q27
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (167680691..167696289, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (169018289..169034192, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (168081371..168096969, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378131 Neighboring gene MPRA-validated peak6319 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168052990-168053978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168072861-168073360 Neighboring gene long intergenic non-protein coding RNA 2538 Neighboring gene uncharacterized LOC124901465 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168085935-168086436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:168103963-168104504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168108302-168109023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168109024-168109744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168113086-168113654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168113655-168114223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:168123500-168124015 Neighboring gene uncharacterized LOC107986547 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168167604-168168104 Neighboring gene serine palmitoyltransferase long chain base subunit 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tumor Suppressor LINC02487 Inhibits the Progression of Cervical Cancer in Vitro by Regulating the PTEN/Akt/mTOR Pathway. Sun R, et al. Discov Med, 2024 Aug. PMID 39190388
    2. Transcriptome analysis reveals differentially expressed lncRNAs between oral squamous cell carcinoma and healthy oral mucosa. Feng L, et al. Oncotarget, 2017 May 9. PMID 28415559, Free PMC Article
    3. Tumor Suppressor LINC02487 Inhibits Oral Squamous Cell Carcinoma Cell Migration and Invasion Through the USP17-SNAI1 Axis. Feng L, et al. Front Oncol, 2020. PMID 33194625, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tumor Suppressor LINC02487 Inhibits the Progression of Cervical Cancer in Vitro by Regulating the PTEN/Akt/mTOR Pathway.
      Title: Tumor Suppressor LINC02487 Inhibits the Progression of Cervical Cancer in Vitro by Regulating the PTEN/Akt/mTOR Pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • MGC138195

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_117092.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL009178, AL356123
      Related
      ENST00000644320.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      167680691..167696289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      169018289..169034192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025489.1: Suppressed sequence

      Description
      NM_001025489.1: This RefSeq was permanently suppressed because currently insufficient support exists for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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