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    ZNF891 zinc finger protein 891 [ Homo sapiens (human) ]

    Gene ID: 101060200, updated on 2-Nov-2024

    Summary

    Official Symbol
    ZNF891provided by HGNC
    Official Full Name
    zinc finger protein 891provided by HGNC
    Primary source
    HGNC:HGNC:38709
    See related
    Ensembl:ENSG00000214029 AllianceGenome:HGNC:38709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 1.3), thyroid (RPKM 0.9) and 24 other tissues See more
    Orthologs
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    Genomic context

    See ZNF891 in Genome Data Viewer
    Location:
    12q24.33
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (133104779..133130274, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (133162095..133187590, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133681365..133706860, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5134 Neighboring gene PTP4A1 pseudogene 2 Neighboring gene ZNF84 divergent transcript Neighboring gene zinc finger protein 84 Neighboring gene MPRA-validated peak2056 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7399 Neighboring gene zinc finger protein 140 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7400 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26228 Neighboring gene ribosomal protein L23a pseudogene 67 Neighboring gene zinc finger protein 10 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:133731795-133732994 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:133757799-133758323 Neighboring gene zinc finger protein 268

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in nucleus  

    General protein information

    Preferred Names
    zinc finger protein 891
    Names
    hCG1646157

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277291.2NP_001264220.1  zinc finger protein 891

      See identical proteins and their annotated locations for NP_001264220.1

      Status: VALIDATED

      Source sequence(s)
      AC026786, BC017932, DA004094, DB295002
      Consensus CDS
      CCDS59238.1
      UniProtKB/Swiss-Prot
      A8MT65
      Related
      ENSP00000437590.1, ENST00000537226.3
      Conserved Domains (6) summary
      smart00349
      Location:4399
      KRAB; krueppel associated box
      COG5048
      Location:272544
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:350370
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:348370
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:4382
      KRAB; KRAB box
      pfam13465
      Location:502527
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      133104779..133130274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      133162095..133187590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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