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    ITSN2 intersectin 2 [ Homo sapiens (human) ]

    Gene ID: 50618, updated on 2-Nov-2024

    Summary

    Official Symbol
    ITSN2provided by HGNC
    Official Full Name
    intersectin 2provided by HGNC
    Primary source
    HGNC:HGNC:6184
    See related
    Ensembl:ENSG00000198399 MIM:604464; AllianceGenome:HGNC:6184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SWA; SWAP; SH3D1B; SH3P18; PRO2015
    Summary
    This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in thyroid (RPKM 16.9), lymph node (RPKM 13.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ITSN2 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (24202864..24361368, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (24237561..24395986, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24425733..24583405, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 228 member B Neighboring gene uncharacterized LOC105374328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15429 Neighboring gene family with sequence similarity 228 member A Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:24475575-24476774 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11230 Neighboring gene ribosomal protein L36a pseudogene 13 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 20 Neighboring gene Sharpr-MPRA regulatory region 9937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:24623030-24623530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24625230-24625736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24625737-24626243 Neighboring gene uncharacterized LOC105374329 Neighboring gene NANOG hESC enhancer GRCh37_chr2:24679828-24680425 Neighboring gene CRISPRi-validated cis-regulatory element chr2.904 Neighboring gene Sharpr-MPRA regulatory region 4589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11232 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:24714093-24714251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11233 Neighboring gene MPRA-validated peak3621 silencer Neighboring gene nuclear receptor coactivator 1 Neighboring gene RNA, 5S ribosomal pseudogene 88

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
    EBI GWAS Catalog
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of intersectin 2 (ITSN2; SH3P18) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1256

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in clathrin-dependent synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of dendrite extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in intracellular vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    intersectin-2
    Names
    SH3 domain-containing protein 1B
    SH3P18-like WASP-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029516.1 RefSeqGene

      Range
      4993..162665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348181.2NP_001335110.1  intersectin-2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC008073, AC009228
      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (12) summary
      cd08375
      Location:15411675
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:193
      EH; Eps15 homology domain
      cd11988
      Location:745801
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:888939
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9711022
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10431101
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11161169
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12001380
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:76168
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:801888
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13981540
      PH_13; Pleckstrin homology domain
      cl26511
      Location:332742
      Neuromodulin_N; Gap junction protein N-terminal region
    2. NM_001348182.2NP_001335111.1  intersectin-2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC008073, AC009228
      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (12) summary
      cd08375
      Location:15151649
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:719775
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:862913
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:945996
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10171075
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:10901143
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:11741354
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16617
      Location:775862
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13721514
      PH_13; Pleckstrin homology domain
      cl25732
      Location:377719
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27427
      Location:126200
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    3. NM_001348183.2NP_001335112.1  intersectin-2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC009228
      UniProtKB/TrEMBL
      Q53TK4
      Conserved Domains (9) summary
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:732788
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:875926
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9581009
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10301088
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11031156
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam15279
      Location:90182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:788875
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl25732
      Location:377727
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_001348184.2NP_001335113.1  intersectin-2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC009228
      UniProtKB/TrEMBL
      Q53TK4
      Conserved Domains (9) summary
      smart00027
      Location:193
      EH; Eps15 homology domain
      cd11988
      Location:718774
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:861912
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:944995
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10161074
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:10891142
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam15279
      Location:76168
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:774861
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl25732
      Location:363713
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_001348185.2NP_001335114.1  intersectin-2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC009228
      UniProtKB/TrEMBL
      Q53TK4
      Conserved Domains (9) summary
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:746802
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:889940
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9721023
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10441102
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11171170
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam16617
      Location:802889
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl26511
      Location:346743
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27427
      Location:126200
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    6. NM_001348186.2NP_001335115.1  intersectin-2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC009228
      UniProtKB/TrEMBL
      Q53TK4
      Conserved Domains (9) summary
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:719775
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:862913
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:945996
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10171075
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:10901143
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam16617
      Location:775862
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl25732
      Location:377719
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27427
      Location:126200
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    7. NM_006277.3NP_006268.2  intersectin-2 isoform 1

      See identical proteins and their annotated locations for NP_006268.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as ITSN2-L, encodes the longest isoform (1).
      Source sequence(s)
      AC008073, AC009228, AF182198, BC146779, DA382952
      Consensus CDS
      CCDS1710.2
      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
      UniProtKB/TrEMBL
      A6H8W8
      Related
      ENSP00000347244.4, ENST00000355123.9
      Conserved Domains (11) summary
      PTZ00121
      Location:346756
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:15551689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:759815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9851036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10571115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11301183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12141394
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16652
      Location:14121555
      PH_13; Pleckstrin homology domain
      cd21577
      Location:91184
      KLF3_N; N-terminal domain of Kruppel-like factor 3
    8. NM_019595.4NP_062541.3  intersectin-2 isoform 3

      See identical proteins and their annotated locations for NP_062541.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 3) that lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC008073, AC009228, AF182198, AF182199, BC146779, DA382952
      Consensus CDS
      CCDS1711.2
      UniProtKB/TrEMBL
      A6H8W8
      Related
      ENSP00000354561.2, ENST00000361999.7
      Conserved Domains (12) summary
      cd08375
      Location:15281662
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:732788
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:875926
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9581009
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10301088
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11031156
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:11871367
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:788875
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13851527
      PH_13; Pleckstrin homology domain
      cl25732
      Location:377727
      SMC_N; RecF/RecN/SMC N terminal domain
    9. NM_147152.3NP_671494.2  intersectin-2 isoform 2

      See identical proteins and their annotated locations for NP_671494.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as ITSN2-S1, has an alternate 3' coding region and 3' UTR compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC009228, AF038189, AF182199, DA382952
      Consensus CDS
      CCDS46230.1
      UniProtKB/TrEMBL
      Q53TK4
      Related
      ENSP00000384499.3, ENST00000406921.7
      Conserved Domains (13) summary
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:759815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9851036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10571115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11301183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:248314
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam08496
      Location:692757
      Peptidase_S49_N; Peptidase family S49 N-terminal
      pfam13499
      Location:249306
      EF-hand_7; EF-hand domain pair
      pfam13868
      Location:387741
      TPH; Trichohyalin-plectin-homology domain
      pfam16617
      Location:815902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:454465
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:379484
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      24202864..24361368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444586.1XP_047300542.1  intersectin-2 isoform X2

    2. XM_047444582.1XP_047300538.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
    3. XM_024452933.2XP_024308701.1  intersectin-2 isoform X3

      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (12) summary
      cd08375
      Location:15421676
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:746802
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:889940
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9721023
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10441102
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11171170
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12011381
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:802889
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13991541
      PH_13; Pleckstrin homology domain
      cl26511
      Location:346743
      Neuromodulin_N; Gap junction protein N-terminal region
    4. XM_024452934.2XP_024308702.1  intersectin-2 isoform X2

      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (12) summary
      cd08375
      Location:15281662
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:732788
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:875926
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9581009
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10301088
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11031156
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:11871367
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:788875
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13851527
      PH_13; Pleckstrin homology domain
      cl25732
      Location:377727
      SMC_N; RecF/RecN/SMC N terminal domain
    5. XM_024452931.2XP_024308699.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (11) summary
      PTZ00121
      Location:346756
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:15551689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:759815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9851036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10571115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11301183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12141394
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16652
      Location:14121555
      PH_13; Pleckstrin homology domain
      cd21577
      Location:91184
      KLF3_N; N-terminal domain of Kruppel-like factor 3
    6. XM_047444584.1XP_047300540.1  intersectin-2 isoform X4

    7. XM_047444583.1XP_047300539.1  intersectin-2 isoform X2

    8. XM_024452930.2XP_024308698.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (11) summary
      PTZ00121
      Location:346756
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:15551689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:759815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9851036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10571115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11301183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12141394
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16652
      Location:14121555
      PH_13; Pleckstrin homology domain
      cd21577
      Location:91184
      KLF3_N; N-terminal domain of Kruppel-like factor 3
    9. XM_024452932.2XP_024308700.1  intersectin-2 isoform X4

      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (12) summary
      cd08375
      Location:15411675
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:193
      EH; Eps15 homology domain
      cd11988
      Location:745801
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:888939
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9711022
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10431101
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11161169
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12001380
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:76168
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:801888
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13981540
      PH_13; Pleckstrin homology domain
      cl26511
      Location:332742
      Neuromodulin_N; Gap junction protein N-terminal region
    10. XM_047444585.1XP_047300541.1  intersectin-2 isoform X4

    11. XM_024452937.2XP_024308705.1  intersectin-2 isoform X9

      Conserved Domains (9) summary
      cd08375
      Location:787921
      C2_Intersectin; C2 domain present in Intersectin
      cd11990
      Location:134185
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:217268
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:289347
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:362415
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:446626
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16617
      Location:47134
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:644786
      PH_13; Pleckstrin homology domain
      cl17036
      Location:1547
      SH3; Src Homology 3 domain superfamily
    12. XM_047444587.1XP_047300543.1  intersectin-2 isoform X5

    13. XM_047444590.1XP_047300546.1  intersectin-2 isoform X8

    14. XM_047444591.1XP_047300547.1  intersectin-2 isoform X8

    15. XM_047444588.1XP_047300544.1  intersectin-2 isoform X6

    16. XM_047444589.1XP_047300545.1  intersectin-2 isoform X7

    17. XM_047444592.1XP_047300548.1  intersectin-2 isoform X10

    18. XM_047444594.1XP_047300550.1  intersectin-2 isoform X12

    19. XM_047444593.1XP_047300549.1  intersectin-2 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      24237561..24395986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342321.1XP_054198296.1  intersectin-2 isoform X2

    2. XM_054342318.1XP_054198293.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
    3. XM_054342319.1XP_054198294.1  intersectin-2 isoform X3

    4. XM_054342322.1XP_054198297.1  intersectin-2 isoform X2

    5. XM_054342317.1XP_054198292.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
    6. XM_054342316.1XP_054198291.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
    7. XM_054342320.1XP_054198295.1  intersectin-2 isoform X4

    8. XM_054342329.1XP_054198304.1  intersectin-2 isoform X9

    9. XM_054342328.1XP_054198303.1  intersectin-2 isoform X9

    10. XM_054342323.1XP_054198298.1  intersectin-2 isoform X5

    11. XM_054342326.1XP_054198301.1  intersectin-2 isoform X8

    12. XM_054342327.1XP_054198302.1  intersectin-2 isoform X8

    13. XM_054342324.1XP_054198299.1  intersectin-2 isoform X6

    14. XM_054342325.1XP_054198300.1  intersectin-2 isoform X7

    15. XM_054342330.1XP_054198305.1  intersectin-2 isoform X10

    16. XM_054342332.1XP_054198307.1  intersectin-2 isoform X12

    17. XM_054342331.1XP_054198306.1  intersectin-2 isoform X11