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    SLC47A1 solute carrier family 47 member 1 [ Homo sapiens (human) ]

    Gene ID: 55244, updated on 2-Nov-2024

    Summary

    Official Symbol
    SLC47A1provided by HGNC
    Official Full Name
    solute carrier family 47 member 1provided by HGNC
    Primary source
    HGNC:HGNC:25588
    See related
    Ensembl:ENSG00000142494 MIM:609832; AllianceGenome:HGNC:25588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MATE1
    Summary
    This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in adrenal (RPKM 59.0), kidney (RPKM 50.0) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLC47A1 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (19533854..19579034)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (19482011..19527180)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19437167..19482347)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 43 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:19408793-19409392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19413581-19414202 Neighboring gene tRNA-Trp (anticodon CCA) 2-1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:19422139-19422858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19455640-19456140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19456141-19456641 Neighboring gene uncharacterized LOC105371578 Neighboring gene small nucleolar RNA, H/ACA box 59B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:19479135-19479710 Neighboring gene SLC47A1 pseudogene 1 Neighboring gene MT-ND1 pseudogene 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ10847, MGC64822

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in basolateral plasma membrane PubMed 
    is_active_in membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    multidrug and toxin extrusion protein 1
    Names
    MATE-1
    hMATE-1
    multidrug and toxin extrusion 1
    solute carrier family 47 (multidrug and toxin extrusion), member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018242.3NP_060712.2  multidrug and toxin extrusion protein 1

      See identical proteins and their annotated locations for NP_060712.2

      Status: VALIDATED

      Source sequence(s)
      AC025627
      Consensus CDS
      CCDS11209.1
      UniProtKB/Swiss-Prot
      Q53HF5, Q6PD77, Q86VL4, Q96FL8, Q9NVA3
      Related
      ENSP00000270570.4, ENST00000270570.8
      Conserved Domains (1) summary
      cd13132
      Location:34468
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      19533854..19579034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      19482011..19527180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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