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    EIF4B eukaryotic translation initiation factor 4B [ Homo sapiens (human) ]

    Gene ID: 1975, updated on 17-Nov-2024

    Summary

    Official Symbol
    EIF4Bprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4Bprovided by HGNC
    Primary source
    HGNC:HGNC:3285
    See related
    Ensembl:ENSG00000063046 MIM:603928; AllianceGenome:HGNC:3285
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF-4B; PRO1843
    Summary
    Enables RNA binding activity. Predicted to be involved in regulation of translational initiation. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 285.6), thyroid (RPKM 146.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See EIF4B in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53006456..53042215)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52970957..53006612)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53400240..53435999)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53292699-53293198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53295217-53296061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4486 Neighboring gene microRNA 9898 Neighboring gene keratin 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53311823-53312324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53312325-53312824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53337539-53338133 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:53339323-53339918 Neighboring gene Sharpr-MPRA regulatory region 15494 Neighboring gene KRT18 locus control region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53358683-53359326 Neighboring gene keratin 18 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53365007-53365934 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53365935-53366860 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:53397033-53397195 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53399611-53400354 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53400355-53401098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53441165-53442009 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53442010-53442853 Neighboring gene TNS2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6402 Neighboring gene tensin 2 Neighboring gene microRNA 6757

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies new prostate cancer susceptibility loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated eukaryotic translation initiation factor 4B (EIF4B) protein is incorporated into HIV-1 Gag virus-like particles PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables RNA strand annealing activity  
    enables RNA strand-exchange activity  
    enables protein binding PubMed 
    enables ribosomal small subunit binding  
    enables translation initiation factor activity  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    part_of eukaryotic translation initiation factor 4F complex PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300821.3NP_001287750.1  eukaryotic translation initiation factor 4B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC068888
      Consensus CDS
      CCDS73474.1
      UniProtKB/TrEMBL
      B4DRM3, E7EX17
      Related
      ENSP00000388806.3, ENST00000420463.7
      Conserved Domains (2) summary
      COG0724
      Location:83190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12402
      Location:95171
      RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins
    2. NM_001330654.2NP_001317583.1  eukaryotic translation initiation factor 4B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC068888
      Consensus CDS
      CCDS86303.1
      UniProtKB/TrEMBL
      B4DRM3
      Related
      ENSP00000412530.3, ENST00000416762.7
    3. NM_001417.7NP_001408.2  eukaryotic translation initiation factor 4B isoform 2

      See identical proteins and their annotated locations for NP_001408.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC068888
      Consensus CDS
      CCDS41788.1
      UniProtKB/Swiss-Prot
      B4DS13, P23588, Q4G0E3, Q53HQ2, Q6GPH5, Q6IB46, Q8WYK5
      UniProtKB/TrEMBL
      B4DRM3
      Related
      ENSP00000262056.9, ENST00000262056.14
      Conserved Domains (3) summary
      PRK12678
      Location:158273
      PRK12678; transcription termination factor Rho; Provisional
      PTZ00108
      Location:372608
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd12402
      Location:94175
      RRM_eIF4B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      53006456..53042215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      52970957..53006612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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