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    GPX7 glutathione peroxidase 7 [ Homo sapiens (human) ]

    Gene ID: 2882, updated on 28-Oct-2024

    Summary

    Official Symbol
    GPX7provided by HGNC
    Official Full Name
    glutathione peroxidase 7provided by HGNC
    Primary source
    HGNC:HGNC:4559
    See related
    Ensembl:ENSG00000116157 MIM:615784; AllianceGenome:HGNC:4559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPX6; CL683; GPx-7; NPGPx; GSHPx-7
    Summary
    Enables catalase activity. Predicted to be involved in cellular response to oxidative stress. Located in endoplasmic reticulum. Implicated in Barrett's adenocarcinoma and Barrett's esophagus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 9.2) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GPX7 in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52602371..52609051)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52483604..52490521)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53068043..53074723)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene terminal uridylyl transferase 4 Neighboring gene uncharacterized LOC105378723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53036969-53037469 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene 7 Neighboring gene uncharacterized LOC124904178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1035 Neighboring gene shisa like 2A Neighboring gene Sharpr-MPRA regulatory region 2435 Neighboring gene Sharpr-MPRA regulatory region 753 Neighboring gene Sharpr-MPRA regulatory region 13275 Neighboring gene MPRA-validated peak230 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 897 Neighboring gene cytochrome c oxidase assembly factor 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with GPX7; predicted interaction to be within the endoplasmic reticulum and function as thioredoxin reductase PubMed
    Tat tat HIV-1 Tat causes a greater than 50% decrease in intracellular reduced glutathione (GSH), leading to the extracellular appearance of acidic FGF-1, an effect that is partially mediated through modulation of GSH biosynthetic enzymes PubMed
    tat Expression of HIV-1 Tat in HeLa cells downregulates cytoplasmic glutathione peroxidase while upregulating phospholipid hydroperoxide glutathione peroxidase, thereby deregulating intracellular oxidant/antioxidant balance and amplifying UV sensitivity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14777

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables catalase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutathione peroxidase 7
    Names
    glutathione peroxidase 6
    non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase
    NP_056511.2
    XP_047274516.1
    XP_047274520.1
    XP_054192135.1
    XP_054192136.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015696.5NP_056511.2  glutathione peroxidase 7 precursor

      See identical proteins and their annotated locations for NP_056511.2

      Status: VALIDATED

      Source sequence(s)
      AK027683, BI550170, BU627166
      Consensus CDS
      CCDS569.1
      UniProtKB/Swiss-Prot
      O95337, Q5T501, Q96SL4
      Related
      ENSP00000354677.4, ENST00000361314.5
      Conserved Domains (1) summary
      TIGR02540
      Location:24176
      gpx7; putative glutathione peroxidase Gpx7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      52602371..52609051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418560.1XP_047274516.1  glutathione peroxidase 7 isoform X1

    2. XM_047418564.1XP_047274520.1  glutathione peroxidase 7 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      52483604..52490521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336160.1XP_054192135.1  glutathione peroxidase 7 isoform X1

    2. XM_054336161.1XP_054192136.1  glutathione peroxidase 7 isoform X2