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    COA7 cytochrome c oxidase assembly factor 7 [ Homo sapiens (human) ]

    Gene ID: 65260, updated on 28-Oct-2024

    Summary

    Official Symbol
    COA7provided by HGNC
    Official Full Name
    cytochrome c oxidase assembly factor 7provided by HGNC
    Primary source
    HGNC:HGNC:25716
    See related
    Ensembl:ENSG00000162377 MIM:615623; AllianceGenome:HGNC:25716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RESA1; SCAN3; SELRC1; C1orf163
    Summary
    Located in mitochondrial intermembrane space and nucleoplasm. Implicated in spinocerebellar ataxia with axonal neuropathy type 3. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in brain (RPKM 6.1), colon (RPKM 6.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See COA7 in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52684449..52698347, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52566007..52579888, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53150121..53164019, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 7 Neighboring gene uncharacterized LOC124904178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1034 Neighboring gene shisa like 2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1035 Neighboring gene Sharpr-MPRA regulatory region 2435 Neighboring gene Sharpr-MPRA regulatory region 753 Neighboring gene Sharpr-MPRA regulatory region 13275 Neighboring gene MPRA-validated peak230 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1036 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53168550-53169091 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53169092-53169632 Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 62, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of Sel1 repeat containing 1 (SELRC1; C1orf163) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    cytochrome c oxidase assembly factor 7
    Names
    Sel1 repeat containing 1
    beta-lactamase hcp-like protein
    cytochrome c oxidase assembly factor 7 (putative)
    epididymis secretory sperm binding protein
    hcp beta-lactamase-like protein C1orf163
    respiratory chain assembly 1
    respiratory chain assembly factor 1
    sel1 repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023077.3NP_075565.2  cytochrome c oxidase assembly factor 7

      See identical proteins and their annotated locations for NP_075565.2

      Status: VALIDATED

      Source sequence(s)
      AC099784, AK022501, BC015313
      Consensus CDS
      CCDS570.1
      UniProtKB/Swiss-Prot
      Q0P6I7, Q96BR5, Q9H9Z9
      UniProtKB/TrEMBL
      A0A384MTZ4
      Related
      ENSP00000360593.3, ENST00000371538.5
      Conserved Domains (2) summary
      COG0790
      Location:31218
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:5080
      SLR; SLR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      52684449..52698347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      52566007..52579888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)