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    CD36 CD36 molecule (CD36 blood group) [ Homo sapiens (human) ]

    Gene ID: 948, updated on 28-Oct-2024

    Summary

    Official Symbol
    CD36provided by HGNC
    Official Full Name
    CD36 molecule (CD36 blood group)provided by HGNC
    Primary source
    HGNC:HGNC:1663
    See related
    Ensembl:ENSG00000135218 MIM:173510; AllianceGenome:HGNC:1663
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10
    Summary
    The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
    Expression
    Biased expression in fat (RPKM 547.7), heart (RPKM 79.1) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CD36 in Genome Data Viewer
    Location:
    7q21.11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (80602207..80679274)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (81853488..81930588)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (80231523..80308590)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986812 Neighboring gene uncharacterized LOC124901685 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:80157849-80158348 Neighboring gene G protein subunit alpha transducin 3 Neighboring gene NANOG hESC enhancer GRCh37_chr7:80162485-80162986 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:80163190-80164389 Neighboring gene Sharpr-MPRA regulatory region 7331 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_100118 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:80393335-80394071 Neighboring gene uncharacterized LOC124901686 Neighboring gene semaphorin 3C Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:80512613-80513812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18334 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:80627598-80627796 Neighboring gene NANOG hESC enhancer GRCh37_chr7:80642207-80642710 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:80703763-80704962 Neighboring gene HNF1 motif-containing MPRA enhancer 195 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:80809759-80810307 Neighboring gene voltage dependent anion channel 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Coronary heart disease, susceptibility to, 7
    MedGen: C1970441 OMIM: 610938 GeneReviews: Not available
    Compare labs
    Malaria, susceptibility to
    MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
    Compare labs
    Platelet-type bleeding disorder 10
    MedGen: C1842090 OMIM: 608404 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
    EBI GWAS Catalog
    Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study.
    EBI GWAS Catalog
    Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.
    EBI GWAS Catalog
    Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env CD36 co-localizes with HIV-1 Env in the cellular virus-containing compartments of macrophages PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD36 molecule (CD36; thrombospondin receptor) in peptide-treated PBMCs PubMed
    Nef nef HIV-1 myristoylated Nef-induced TNF-alpha release leads to downregulation of CD36 expression by myristoylated Nef in monocyte-derived macrophages PubMed
    nef HIV-1 myristoylated Nef downregulates CD36 expression in monocytes from PBMCs and monocyte-derived macrophages differentiated by cytokines. Nef-dependent downregulation of CD36 involves mRNA transcriptional inhibition PubMed
    Pr55(Gag) gag CD36 co-localizes with HIV-1 Gag in the cellular virus-containing compartments and is required for efficient HIV-1 release by primary macrophages PubMed
    capsid gag CD36 induces release of p24 in primary macrophages. Knockdown of CD36 by siRNA restricts the activity of CD36 PubMed
    matrix gag Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Toll-like receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables amyloid-beta binding IC
    Inferred by Curator
    more info
    PubMed 
    enables amyloid-beta binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amyloid-beta binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables cargo receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables high-density lipoprotein particle binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipoteichoic acid immune receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables long-chain fatty acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables low-density lipoprotein particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables low-density lipoprotein particle receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables low-density lipoprotein particle receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables low-density lipoprotein particle receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables oleate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxidised low-density lipoprotein particle receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables scavenger receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables scavenger receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables short-chain fatty acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables thrombospondin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thrombospondin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transforming growth factor beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid fibril formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in amyloid-beta clearance by cellular catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in amyloid-beta clearance by cellular catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood coagulation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amyloid-beta IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to diacyl bacterial lipopeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to diacyl bacterial lipopeptide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hydroperoxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipoteichoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to low-density lipoprotein particle stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in energy homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fatty acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intestinal absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intestinal cholesterol absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid transport across blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipoprotein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipoprotein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipoprotein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in long-chain fatty acid import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty acid import into cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in low-density lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in low-density lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in low-density lipoprotein particle mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nitric oxide-cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oxidised low-density lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagocytosis, engulfment TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phagocytosis, recognition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NLRP3 inflammasome complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood microparticle formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cholesterol storage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-1 beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage derived foam cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phagocytosis, engulfment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of reactive oxygen species biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in production of molecular mediator involved in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of lipopolysaccharide-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of toll-like receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to fatty acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to linoleic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to lipid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to stilbenoid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of taste ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in short-chain fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in triglyceride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in caveola IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle TAS
    Traceable Author Statement
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in platelet alpha granule membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    platelet glycoprotein 4
    Names
    CD36 antigen (collagen type I receptor, thrombospondin receptor)
    CD36 molecule (thrombospondin receptor)
    GPIIIB
    PAS IV
    PAS-4 protein
    cluster determinant 36
    fatty acid translocase
    glycoprotein IIIb
    leukocyte differentiation antigen CD36
    platelet glycoprotein IV
    scavenger receptor class B, member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008192.1 RefSeqGene

      Range
      41455..82087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000072.3NP_000063.2  platelet glycoprotein 4 isoform 1

      See identical proteins and their annotated locations for NP_000063.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (1). Variants 1-5 and 10-13 all encode the same isoform (1).
      Source sequence(s)
      AC124834, DA857400, DC338512, L06850, M98398
      Consensus CDS
      CCDS34673.1
      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Related
      ENSP00000378268.3, ENST00000394788.7
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family
    2. NM_001001547.3NP_001001547.1  platelet glycoprotein 4 isoform 1

      See identical proteins and their annotated locations for NP_001001547.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
      Source sequence(s)
      BP258762, BP259746, L06850, M98398
      Consensus CDS
      CCDS34673.1
      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Related
      ENSP00000308165.7, ENST00000309881.11
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family
    3. NM_001001548.3NP_001001548.1  platelet glycoprotein 4 isoform 1

      See identical proteins and their annotated locations for NP_001001548.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has an alternate 3' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
      Source sequence(s)
      AC073850, AC124834
      Consensus CDS
      CCDS34673.1
      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Related
      ENSP00000415743.2, ENST00000447544.7
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family
    4. NM_001127443.2NP_001120915.1  platelet glycoprotein 4 isoform 1

      See identical proteins and their annotated locations for NP_001120915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
      Source sequence(s)
      AC073850, DA566475, L06850, M98398
      Consensus CDS
      CCDS34673.1
      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Related
      ENSP00000411411.1, ENST00000432207.5
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family
    5. NM_001127444.2NP_001120916.1  platelet glycoprotein 4 isoform 1

      See identical proteins and their annotated locations for NP_001120916.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
      Source sequence(s)
      AL596924, L06850, M98398
      Consensus CDS
      CCDS34673.1
      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Related
      ENSP00000392298.2, ENST00000419819.2
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family
    6. NM_001289908.1NP_001276837.1  platelet glycoprotein 4 isoform 2

      See identical proteins and their annotated locations for NP_001276837.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two consecutive exons in the 3' coding region, compared to variant 3. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK300101, HM217026, L06850
      Consensus CDS
      CCDS78249.1
      UniProtKB/TrEMBL
      B3KUB8, D9IX63, D9IX64, D9IX65
      Related
      ENSP00000401863.2, ENST00000433696.6
      Conserved Domains (1) summary
      pfam01130
      Location:16422
      CD36; CD36 family
    7. NM_001289909.1NP_001276838.1  platelet glycoprotein 4 isoform 3

      See identical proteins and their annotated locations for NP_001276838.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an in-frame coding exon, compared to variant 3. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK300101, BC008406, HM217023, L06850
      Consensus CDS
      CCDS78250.1
      UniProtKB/TrEMBL
      B3KUB8, D9IX65
      Related
      ENSP00000439543.1, ENST00000538969.5
      Conserved Domains (1) summary
      pfam01130
      Location:16401
      CD36; CD36 family
    8. NM_001289911.2NP_001276840.1  platelet glycoprotein 4 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate downstream AUG, compared to variant 3. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK300101, AK312920, L06850
      Consensus CDS
      CCDS78251.1
      UniProtKB/TrEMBL
      B7Z6C3, E9PLT1
      Related
      ENSP00000431296.1, ENST00000534394.5
      Conserved Domains (1) summary
      pfam01130
      Location:1385
      CD36; CD36 family
    9. NM_001371074.1NP_001358003.1  platelet glycoprotein 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1-5 and 11-13, encodes isoform 1.
      Source sequence(s)
      AC073182, AC073850
      Consensus CDS
      CCDS34673.1
      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family
    10. NM_001371075.1NP_001358004.1  platelet glycoprotein 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 1-5, 10, 12, and 13, encodes isoform 1.
      Source sequence(s)
      AC073182, AC073850
      Consensus CDS
      CCDS34673.1
      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family
    11. NM_001371077.1NP_001358006.1  platelet glycoprotein 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 1-5, 10, 11, and 13, encodes isoform 1.
      Source sequence(s)
      AC073850, AC124834
      Consensus CDS
      CCDS34673.1
      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family
    12. NM_001371078.1NP_001358007.1  platelet glycoprotein 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 1-5 and 10-12, encodes isoform 1.
      Source sequence(s)
      AC073850, AC124834
      Consensus CDS
      CCDS34673.1
      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Related
      ENSP00000399421.1, ENST00000435819.5
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family
    13. NM_001371079.1NP_001358008.1  platelet glycoprotein 4 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC073850, AC124834
      UniProtKB/TrEMBL
      D9IX64
      Conserved Domains (1) summary
      pfam01130
      Location:16429
      CD36; CD36 family
    14. NM_001371080.1NP_001358009.1  platelet glycoprotein 4 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform 6.
      Source sequence(s)
      AC073182, AC073850
      UniProtKB/TrEMBL
      B7Z6C3
      Conserved Domains (1) summary
      pfam01130
      Location:1308
      CD36; CD36 family
    15. NM_001371081.1NP_001358010.1  platelet glycoprotein 4 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform 6.
      Source sequence(s)
      AC073182, AC073850
      UniProtKB/TrEMBL
      B7Z6C3
      Conserved Domains (1) summary
      pfam01130
      Location:1308
      CD36; CD36 family

    RNA

    1. NR_110501.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an internal exon in the 3' region, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK300101, BC008406, HM217025, L06850
      Related
      ENST00000544133.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      80602207..80679274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447003.2XP_024302771.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family
    2. XM_047421046.1XP_047277002.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    3. XM_047421041.1XP_047276997.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    4. XM_047421043.1XP_047276999.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    5. XM_047421042.1XP_047276998.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    6. XM_047421044.1XP_047277000.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    7. XM_047421045.1XP_047277001.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    8. XM_047421049.1XP_047277005.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    9. XM_047421047.1XP_047277003.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    10. XM_047421048.1XP_047277004.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    11. XM_005250715.6XP_005250772.1  platelet glycoprotein 4 isoform X1

      See identical proteins and their annotated locations for XP_005250772.1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family
    12. XM_024447002.2XP_024302770.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
      Conserved Domains (1) summary
      pfam01130
      Location:14463
      CD36; CD36 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      81853488..81930588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359367.1XP_054215342.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    2. XM_054359365.1XP_054215340.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    3. XM_054359368.1XP_054215343.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    4. XM_054359360.1XP_054215335.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    5. XM_054359362.1XP_054215337.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    6. XM_054359361.1XP_054215336.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    7. XM_054359364.1XP_054215339.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    8. XM_054359366.1XP_054215341.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    9. XM_054359359.1XP_054215334.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1
    10. XM_054359363.1XP_054215338.1  platelet glycoprotein 4 isoform X1

      UniProtKB/Swiss-Prot
      D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
      UniProtKB/TrEMBL
      A4D1B1