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    WDR97 WD repeat domain 97 [ Homo sapiens (human) ]

    Gene ID: 340390, updated on 17-Sep-2024

    Summary

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    Official Symbol
    WDR97provided by HGNC
    Official Full Name
    WD repeat domain 97provided by HGNC
    Primary source
    HGNC:HGNC:26959
    See related
    Ensembl:ENSG00000179698 AllianceGenome:HGNC:26959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA1875
    Summary
    The function and protein-coding potential of this gene is unknown. The exon combination is based on AB058778.1 for which two possible open reading frames can be predicted (with start codons at nucleotide 26 or 2614). The position of the first ORF stop codon is consistent with a prediction of nonsense-mediated decay. Given the observation of the first ORF and its length, a predicted translation of the second ORF is inconsistent with the translation leaky scanning theory. Therefore, this gene is represented as a non-protein-coding transcript. [provided by RefSeq, Oct 2008]
    Expression
    Biased expression in testis (RPKM 5.3), brain (RPKM 0.6) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See WDR97 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144107739..144118328)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145268535..145279125)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145162642..145173231)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene SHANK associated RH domain interactor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28089 Neighboring gene Sharpr-MPRA regulatory region 2030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145163585-145164115 Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19661 Neighboring gene HGH1 homolog Neighboring gene testis specific serine kinase 5, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    WD repeat-containing protein 97

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316309.2 → NP_001303238.1  WD repeat-containing protein 97

      Status: VALIDATED

      Source sequence(s)
      AC104592
      Consensus CDS
      CCDS83334.1
      UniProtKB/Swiss-Prot
      A6NE52, Q96JF2
      Related
      ENSP00000320648.8, ENST00000323662.9
      Conserved Domains (3) summary
      COG2319
      Location:206 → 363
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:252 → 288
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:200 → 370
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144107739..144118328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421748.1 → XP_047277704.1  WD repeat-containing protein 97 isoform X3

    2. XM_047421746.1 → XP_047277702.1  WD repeat-containing protein 97 isoform X1

    3. XM_047421747.1 → XP_047277703.1  WD repeat-containing protein 97 isoform X2

    4. XM_047421750.1 → XP_047277706.1  WD repeat-containing protein 97 isoform X5

    5. XM_047421751.1 → XP_047277707.1  WD repeat-containing protein 97 isoform X6

    6. XM_047421749.1 → XP_047277705.1  WD repeat-containing protein 97 isoform X4

    7. XM_047421753.1 → XP_047277709.1  WD repeat-containing protein 97 isoform X8

    8. XM_047421752.1 → XP_047277708.1  WD repeat-containing protein 97 isoform X7

    9. XM_047421754.1 → XP_047277710.1  WD repeat-containing protein 97 isoform X9

    10. XM_047421755.1 → XP_047277711.1  WD repeat-containing protein 97 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      145268535..145279125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360417.1 → XP_054216392.1  WD repeat-containing protein 97 isoform X3

    2. XM_054360415.1 → XP_054216390.1  WD repeat-containing protein 97 isoform X1

    3. XM_054360416.1 → XP_054216391.1  WD repeat-containing protein 97 isoform X2

    4. XM_054360419.1 → XP_054216394.1  WD repeat-containing protein 97 isoform X5

    5. XM_054360420.1 → XP_054216395.1  WD repeat-containing protein 97 isoform X6

    6. XM_054360418.1 → XP_054216393.1  WD repeat-containing protein 97 isoform X4

    7. XM_054360422.1 → XP_054216397.1  WD repeat-containing protein 97 isoform X8

    8. XM_054360421.1 → XP_054216396.1  WD repeat-containing protein 97 isoform X7

    9. XM_054360423.1 → XP_054216398.1  WD repeat-containing protein 97 isoform X9

    10. XM_054360424.1 → XP_054216399.1  WD repeat-containing protein 97 isoform X10

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032529.1: Suppressed sequence

      Description
      NM_032529.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NR_024207.1: Suppressed sequence

      Description
      NR_024207.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NE52.2 GenPept UniProtKB/Swiss-Prot:A6NE52

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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