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    cmd-1 Calmodulin;EF-hand domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178614, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cmd-1
    Official Full Name
    Calmodulin;EF-hand domain-containing protein
    Primary source
    WormBase:WBGene00000552
    Locus tag
    CELE_T21H3.3
    See related
    AllianceGenome:WB:WBGene00000552
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity and enzyme regulator activity. Involved in several processes, including apoptotic cell clearance; establishment of meiotic spindle orientation; and positive chemotaxis. Located in cell periphery; microtubule cytoskeleton; and nuclear membrane. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 4; familial hypertrophic cardiomyopathy; long QT syndrome 14; long QT syndrome 15; and long QT syndrome 16. Orthologous to human CALM1 (calmodulin 1); CALM2 (calmodulin 2); and CALM3 (calmodulin 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cmd-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (1156271..1158189)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ZP domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of the single calmodulin gene in the nematode Caenorhabditis elegans by RNA interference and 4-D microscopy. Karabinos A, et al. Eur J Cell Biol, 2003 Nov. PMID 14703012
    2. Social feeding in Caenorhabditis elegans is modulated by antipsychotic drugs and calmodulin and may serve as a protophenotype for asociality. Dwyer DS, et al. Neuropharmacology, 2015 May. PMID 25576370
    3. Analysis of Ca2+ signaling motifs that regulate proton signaling through the Na+/H+ exchanger NHX-7 during a rhythmic behavior in Caenorhabditis elegans. Allman E, et al. J Biol Chem, 2013 Feb 22. PMID 23319594, Free PMC Article
    4. Neuronal calmodulin levels are controlled by CAMTA transcription factors. Vuong-Brender TT, et al. Elife, 2021 Sep 9. PMID 34499028, Free PMC Article
    5. A systems biology-based identification and in vivo functional screening of Alzheimer's disease risk genes reveal modulators of memory function. Hudgins AD, et al. Neuron, 2024 Jul 3. PMID 38692279,

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ASPM-1, together with calmodulin (CMD-1), promotes meiotic spindle organization and the accumulation of LIN-5 at meiotic and mitotic spindle poles.
      Title: NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of meiotic spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of meiotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Calmodulin;EF-hand domain-containing protein
    NP_001300203.1
    • Confirmed by transcript evidence
    NP_503386.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1156271..1158189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070985.7 → NP_503386.1  Calmodulin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503386.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16305
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 149
      PTZ00184; calmodulin; Provisional

    2. NM_001313274.3 → NP_001300203.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVX0
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 113
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16305.3

    Gene LinkOut

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