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    mat-3 Cell division cycle protein 23 homolog [ Caenorhabditis elegans ]

    Gene ID: 175205, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mat-3
    Official Full Name
    Cell division cycle protein 23 homolog
    Primary source
    WormBase:WBGene00003134
    Locus tag
    CELE_F10C5.1
    See related
    AllianceGenome:WB:WBGene00003134
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable molecular adaptor activity. Involved in asymmetric cell division; polarity specification of anterior/posterior axis; and positive regulation of metaphase/anaphase transition of meiosis I. Predicted to be part of anaphase-promoting complex. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mat-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (475454..482325)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene MAGUK family Neighboring gene Nuclear envelope integral membrane protein Neighboring gene Ovule protein Neighboring gene YGGWG-amide

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and sequencing of temperature sensitive alleles of the Anaphase Promoting Complex component mat-3 in C. elegans. Maniates KA, et al. MicroPubl Biol, 2023. PMID 37614776, Free PMC Article
    2. The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix. Zhang Z, et al. J Mol Biol, 2013 Nov 15. PMID 23583778, Free PMC Article
    3. E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development. Kulkarni M, et al. PLoS Genet, 2008 Jul 18. PMID 18636104, Free PMC Article
    4. Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities. Shakes DC, et al. Development, 2003 Apr. PMID 12620985, Free PMC Article
    5. Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis. Stein KK, et al. Genetics, 2010 Dec. PMID 20944012, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SynMuv B genes suppress mat-3(ku233) defects by restoring mat-3 mRNA to wild-type levels.
      Title: Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polarity specification of anterior/posterior axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of metaphase/anaphase transition of meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cell division cycle protein 23 homolog
    NP_497203.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      475454..482325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064802.7 → NP_497203.1  Cell division cycle protein 23 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497203.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19294
      Conserved Domains (2) summary
      sd00006
      Location:434 → 462
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:434 → 499
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19294.2

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