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    epn-1 ENTH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181577, updated on 2-Nov-2024

    Summary

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    Official Symbol
    epn-1
    Official Full Name
    ENTH domain-containing protein
    Primary source
    WormBase:WBGene00001329
    Locus tag
    CELE_T04C10.2
    See related
    AllianceGenome:WB:WBGene00001329
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in endocytosis. Located in early phagosome; phagocytic cup; and pseudopodium. Is expressed in several structures, including coelomocyte; hypodermis; intestine; nervous system; and reproductive system. Orthologous to human EPN1 (epsin 1); EPN2 (epsin 2); and EPN3 (epsin 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See epn-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (14815798..14818514, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Transcription factor atf-4 homolog Neighboring gene ncRNA Neighboring gene Coiled-coil domain-containing protein 96 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A C. elegans genome-wide RNAi screen for altered levamisole sensitivity identifies genes required for muscle function. Chaya T, et al. G3 (Bethesda), 2021 Apr 15. PMID 33713125, Free PMC Article
    2. Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans. Shen Q, et al. Development, 2013 Aug. PMID 23861060, Free PMC Article
    3. Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins. Langridge PD, et al. Curr Biol, 2022 May 23. PMID 35349791, Free PMC Article
    4. Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1. Kang YL, et al. Mol Biol Cell, 2013 Feb. PMID 23242996, Free PMC Article
    5. Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development. Oommen KS, et al. Development, 2007 Nov. PMID 17942488

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inactivating epn-1 or chc-1 disrupts engulfment by impairing actin polymerization. CHC-1 is enriched on extending pseudopods together with EPN-1, in an EPN-1-dependent manner.
      Title: Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans.
    2. EPN-1/epsin as an essential factor in promoting internalization of the C. elegans LDLR superfamily member LRP-1.
      Title: Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early phagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic cup IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pseudopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ENTH domain-containing protein
    NP_510458.1
    • Confirmed by transcript evidence
    NP_510459.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14815798..14818514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078058.6 → NP_510459.1  ENTH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510459.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BI72
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    2. NM_078057.8 → NP_510458.1  ENTH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BI71
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    Nucleotide Protein
    Heading Accession and Version

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