asp-12 Peptidase A1 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: asp-12
Official Full Name: Peptidase A1 domain-containing protein
Primary source: WormBase:WBGene00017678
Locus tag: CELE_F21F8.4
See related: AllianceGenome:WB:WBGene00017678
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable aspartic-type endopeptidase activity. Involved in innate immune response. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See asp-12 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (8270643..8272056)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS5-275 (e-PCR)
- UniSTS:242444

STS5-170 (e-PCR)
- UniSTS:242329

F21F8.4 (e-PCR)
- UniSTS:312280

F21F8.7 (e-PCR)
- UniSTS:312282

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	HEP more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Peptidase A1 domain-containing protein

NP_505134.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

8270643..8272056

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072733.7 → NP_505134.1 Peptidase A1 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505134.1

Status: REVIEWED

UniProtKB/TrEMBL

O01531

Conserved Domains (1) summary

pfam00026
Location:72 → 388

Asp; Eukaryotic aspartyl protease