COX6B2 cytochrome c oxidase subunit 6B2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: COX6B2provided by HGNC
Official Full Name: cytochrome c oxidase subunit 6B2provided by HGNC
Primary source: HGNC:HGNC:24380
See related: Ensembl:ENSG00000160471 MIM:618127; AllianceGenome:HGNC:24380
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT59; COXVIB2
Summary: Predicted to be involved in oxidative phosphorylation. Located in mitochondrial crista. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis (RPKM 26.9) See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.42

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (55349704..55354719, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (58445210..58450225, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (55861072..55866087, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[High expression of COX6B2 in gastric cancer is associated with poor long-term prognosis and promotes cell proliferation and cell cycle progression by inhibiting p53 signaling].
Title: [High expression of COX6B2 in gastric cancer is associated with poor long-term prognosis and promotes cell proliferation and cell cycle progression by inhibiting p53 signaling].
Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma.
Title: Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of cytochrome c oxidase subunit VIb polypeptide 2 (COX6B2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D8S2279 (e-PCR)
- UniSTS:473907

D10S16 (e-PCR)
- UniSTS:155756

D1S1423 (e-PCR)
- UniSTS:149619

D11S3114 (e-PCR)
- UniSTS:152207

NoName (e-PCR)
- UniSTS:482983

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in oxidative phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial crista	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial crista	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
located_in mitochondrion	HTP more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex IV	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome c oxidase subunit 6B2

Names: COX VIb-2; cancer/testis antigen 59; cytochrome c oxidase subunit VIb polypeptide 2 (testis); cytochrome c oxidase subunit VIb, testes-specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001369798.1 → NP_001356727.1 cytochrome c oxidase subunit 6B2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.

Source sequence(s)

AC020922, AK057427

Consensus CDS

CCDS42630.1

UniProtKB/Swiss-Prot

Q6YFQ2, Q7L1R4, Q96DL5

Related

ENSP00000467266.1, ENST00000593184.5

Conserved Domains (1) summary

cd00926
Location:10 → 87

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_001369799.1 → NP_001356728.1 cytochrome c oxidase subunit 6B2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AC020922

Consensus CDS

CCDS42630.1

UniProtKB/Swiss-Prot

Q6YFQ2, Q7L1R4, Q96DL5

Conserved Domains (1) summary

cd00926
Location:10 → 87

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_001369800.1 → NP_001356729.1 cytochrome c oxidase subunit 6B2

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 3' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AC020922

Consensus CDS

CCDS42630.1

UniProtKB/Swiss-Prot

Q6YFQ2, Q7L1R4, Q96DL5

Conserved Domains (1) summary

cd00926
Location:10 → 87

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_144613.5 → NP_653214.2 cytochrome c oxidase subunit 6B2

See identical proteins and their annotated locations for NP_653214.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

BC026123, BG717038

Consensus CDS

CCDS42630.1

UniProtKB/Swiss-Prot

Q6YFQ2, Q7L1R4, Q96DL5

Related

ENSP00000320672.3, ENST00000326529.9

Conserved Domains (1) summary

cd00926
Location:10 → 87

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...