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    ZSWIM9 zinc finger SWIM-type containing 9 [ Homo sapiens (human) ]

    Gene ID: 374920, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZSWIM9provided by HGNC
    Official Full Name
    zinc finger SWIM-type containing 9provided by HGNC
    Primary source
    HGNC:HGNC:34495
    See related
    Ensembl:ENSG00000185453 AllianceGenome:HGNC:34495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C19orf68
    Summary
    Predicted to act upstream of or within hematopoietic progenitor cell differentiation. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in brain (RPKM 3.0), fat (RPKM 2.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZSWIM9 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48170680..48197620)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51164635..51191690)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48673937..48700877)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48564610-48565203 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48565204-48565796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48565797-48566389 Neighboring gene phospholipase A2 group IVC Neighboring gene PLA2G4C antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10871 Neighboring gene DNA ligase 1 Neighboring gene uncharacterized LOC107985293 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48673083-48673742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14872 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48691653-48691885 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48699771-48700283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14873 Neighboring gene uncharacterized LOC124904734 Neighboring gene caspase recruitment domain family member 8 Neighboring gene vomeronasal 1 receptor 97 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide identification and spatiotemporal expression profiling of zinc finger SWIM domain-containing protein family genes. Hassan IU, et al. Zool Res, 2023 May 18. PMID 37161653, Free PMC Article
    2. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Connaughton DM, et al. Am J Hum Genet, 2020 Oct 1. PMID 32891193, Free PMC Article
    3. A comprehensive resource of interacting protein regions for refining human transcription factor networks. Miyamoto-Sato E, et al. PLoS One, 2010 Feb 24. PMID 20195357, Free PMC Article
    4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. Hosgood HD 3rd, et al. Occup Environ Med, 2009 Dec. PMID 19773279, Free PMC Article
    5. TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN. Zhang K, et al. Cell Mol Life Sci, 2023 May 30. PMID 37249651, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC50339

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein ZSWIM9
    Names
    uncharacterized protein C19orf68

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199341.4 → NP_955373.3  uncharacterized protein ZSWIM9

      See identical proteins and their annotated locations for NP_955373.3

      Status: VALIDATED

      Source sequence(s)
      AC011466, BC043386
      Consensus CDS
      CCDS74411.1
      UniProtKB/Swiss-Prot
      Q86XI8
      Related
      ENSP00000480314.1, ENST00000614654.2
      Conserved Domains (1) summary
      pfam03101
      Location:97 → 128
      FAR1; FAR1 DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      48170680..48197620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259449.4 → XP_005259506.1  uncharacterized protein ZSWIM9 isoform X2

      Conserved Domains (1) summary
      pfam03101
      Location:110 → 141
      FAR1; FAR1 DNA-binding domain

    2. XM_006723204.4 → XP_006723267.1  uncharacterized protein ZSWIM9 isoform X1

      Conserved Domains (1) summary
      pfam03101
      Location:124 → 155
      FAR1; FAR1 DNA-binding domain

    3. XM_006723205.3 → XP_006723268.1  uncharacterized protein ZSWIM9 isoform X3

      See identical proteins and their annotated locations for XP_006723268.1

      Conserved Domains (1) summary
      pfam03101
      Location:97 → 128
      FAR1; FAR1 DNA-binding domain

    4. XM_011526936.3 → XP_011525238.1  uncharacterized protein ZSWIM9 isoform X4

      Conserved Domains (1) summary
      pfam03101
      Location:9 → 56
      FAR1; FAR1 DNA-binding domain

    5. XM_047438788.1 → XP_047294744.1  uncharacterized protein ZSWIM9 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      51164635..51191690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320933.1 → XP_054176908.1  uncharacterized protein ZSWIM9 isoform X3

    2. XM_054320931.1 → XP_054176906.1  uncharacterized protein ZSWIM9 isoform X2

    3. XM_054320930.1 → XP_054176905.1  uncharacterized protein ZSWIM9 isoform X1

    4. XM_054320932.1 → XP_054176907.1  uncharacterized protein ZSWIM9 isoform X4

    5. XM_054320934.1 → XP_054176909.1  uncharacterized protein ZSWIM9 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86XI8.2 GenPept UniProtKB/Swiss-Prot:Q86XI8

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