U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mbtr-1 Malignant brain tumor repeat protein 1 [ Caenorhabditis elegans ]

    Gene ID: 171624, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mbtr-1
    Official Full Name
    Malignant brain tumor repeat protein 1
    Primary source
    WormBase:WBGene00021661
    Locus tag
    CELE_Y48G1A.6
    See related
    AllianceGenome:WB:WBGene00021661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to several human genes including L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) and MBTD1 (mbt domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mbtr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (343069..348424, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nucleolar protein 14 Neighboring gene Dauer abnormal formation protein 25 Neighboring gene Transposase Neighboring gene BTB domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development. Koester-Eiserfunke N, et al. PLoS Genet, 2011 Mar. PMID 21437264, Free PMC Article
    2. LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes. Harrison MM, et al. Genetics, 2007 May. PMID 17409073, Free PMC Article
    3. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Malignant brain tumor repeat protein 1
    NP_001122542.1
    • Confirmed by transcript evidence
    NP_001122543.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      343069..348424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129070.2 → NP_001122542.1  Malignant brain tumor repeat protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122542.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0SQM0, A9D1A1
      Conserved Domains (3) summary
      smart00561
      Location:217 → 326
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam02820
      Location:374 → 439
      MBT; mbt repeat
      cl17705
      Location:75 → 164
      MBT; mbt repeat

    2. NM_001129071.3 → NP_001122543.1  Malignant brain tumor repeat protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0SQM0
      Conserved Domains (3) summary
      smart00561
      Location:204 → 313
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      cd20099
      Location:356 → 447
      MBT_dSfmbt-like_rpt3; third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family
      cl45897
      Location:466 → 536
      MBT; malignant brain tumor (MBT) repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0SQM0.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools