U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    xpo-2 Exportin-2;Exportin-2 C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171621, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    xpo-2
    Official Full Name
    Exportin-2;Exportin-2 C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00002079
    Locus tag
    CELE_Y48G1A.5
    See related
    AllianceGenome:WB:WBGene00002079
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus and protein import into nucleus. Predicted to be active in cytosol and nuclear envelope. Orthologous to human CSE1L (chromosome segregation 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See xpo-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (318549..323352, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Importin N-terminal domain-containing protein Neighboring gene pseudo Neighboring gene Nucleolar protein 14 Neighboring gene Dauer abnormal formation protein 25

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Quan Y, et al. Mol Cell Proteomics, 2008 Jul. PMID 18353765, Free PMC Article
    2. AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans. Pispa J, et al. iScience, 2023 Oct 20. PMID 37767001, Free PMC Article
    3. Functional genomic analysis of RNA interference in C. elegans. Kim JK, et al. Science, 2005 May 20. PMID 15790806
    4. A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes. Zugasti O, et al. BMC Biol, 2016 Apr 29. PMID 27129311, Free PMC Article
    5. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Exportin-2;Exportin-2 C-terminal domain-containing protein
    NP_001293261.1
    • Confirmed by transcript evidence
    NP_490716.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      318549..323352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058315.7 → NP_490716.1  Exportin-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q965V4
      Conserved Domains (2) summary
      COG5657
      Location:3 → 799
      CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
      pfam08506
      Location:150 → 513
      Cse1

    2. NM_001306332.3 → NP_001293261.1  Exportin-2 C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CKP0
      Conserved Domains (1) summary
      pfam03378
      Location:4 → 89
      CAS_CSE1; CAS/CSE protein, C-terminus
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools