OPA1 OPA1 mitochondrial dynamin like GTPase [Homo sapiens (human)] - Gene

Summary

Official Symbol: OPA1provided by HGNC
Official Full Name: OPA1 mitochondrial dynamin like GTPaseprovided by HGNC
Primary source: HGNC:HGNC:8140
See related: Ensembl:ENSG00000198836 MIM:605290; AllianceGenome:HGNC:8140
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NPG; NTG; MGM1; BERHS; largeG; MTDPS14
Summary: The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]
Expression: Ubiquitous expression in brain (RPKM 20.5), heart (RPKM 17.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q29

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (193593208..193697811)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (196288807..196394453)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (193310997..193415600)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p32/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer.
Title: p32/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer.
Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function.
Title: Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function.
Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease.
Title: Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease.
Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer.
Title: Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer.
BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells.
Title: BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells.
OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases.
Title: OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases.
OPA1 helical structures give perspective to mitochondrial dysfunction.
Title: OPA1 helical structures give perspective to mitochondrial dysfunction.
Structural mechanism of mitochondrial membrane remodelling by human OPA1.
Title: Structural mechanism of mitochondrial membrane remodelling by human OPA1.
Mitochondrial dynamics-related genes DRP1 and OPA1 contributes to early diagnosis of cognitive impairment in diabetes.
Title: Mitochondrial dynamics-related genes DRP1 and OPA1 contributes to early diagnosis of cognitive impairment in diabetes.
[Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases].
Title: [Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases].

Submit: New GeneRIF Correction See all GeneRIFs (237)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Abortive cerebellar ataxia MedGen: C0221061 OMIM: 210000 GeneReviews: Mitochondrial DNA Maintenance Defects Overview	Compare labs
Autosomal dominant optic atrophy classic form MedGen: C0338508 OMIM: 165500 GeneReviews: Optic Atrophy Type 1	Compare labs
Glaucoma, normal tension, susceptibility to MedGen: C1847730 OMIM: 606657 GeneReviews: Not available	Compare labs
Mitochondrial DNA depletion syndrome 14 (cardioencephalomyopathic type) MedGen: C4225163 OMIM: 616896 GeneReviews: Mitochondrial DNA Maintenance Defects Overview	Compare labs
Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy MedGen: C3276549 OMIM: 125250 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of optic atrophy 1 (OPA1, dynamin-like 120 kDa protein, mitochondrial) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-77668 (e-PCR)
- UniSTS:21793

SHGC-37414 (e-PCR)
- UniSTS:21796

OPA1__6114 (e-PCR)
- UniSTS:463662

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

SHGC-31084 (e-PCR)
- UniSTS:62316

RH78614 (e-PCR)
- UniSTS:11888

D1S1423 (e-PCR)
- UniSTS:149619

SGC38140 (e-PCR)
- UniSTS:81567

SHGC-77667 (e-PCR)
- UniSTS:70071

RH36294 (e-PCR)
- UniSTS:25056

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables cardiolipin binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	NAS Non-traceable Author Statement more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in GTP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axonal transport of mitochondrion	TAS Traceable Author Statement more info	PubMed
involved_in cellular senescence	IDA Inferred from Direct Assay more info	PubMed
involved_in inner mitochondrial membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane tubulation	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial fission	TAS Traceable Author Statement more info	PubMed
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fusion	TAS Traceable Author Statement more info	PubMed
involved_in mitochondrial genome maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
involved_in protein complex oligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial crista	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: dynamin-like 120 kDa protein, mitochondrial

Names: dynamin-like guanosine triphosphatase; mitochondrial dynamin-like GTPase; optic atrophy 1 (autosomal dominant); optic atrophy protein 1

NP_001341592.1

EC 3.6.5.5

NP_001341593.1

EC 3.6.5.5

NP_056375.2

EC 3.6.5.5

NP_570844.1

EC 3.6.5.5

NP_570845.1

EC 3.6.5.5

NP_570846.1

EC 3.6.5.5

NP_570847.2

EC 3.6.5.5

NP_570848.1

EC 3.6.5.5

NP_570849.2

EC 3.6.5.5

NP_570850.2

EC 3.6.5.5

XP_047304162.1

EC 3.6.5.5

XP_047304163.1

EC 3.6.5.5

XP_047304164.1

EC 3.6.5.5

XP_047304165.1

EC 3.6.5.5

XP_047304166.1

EC 3.6.5.5

XP_047304167.1

EC 3.6.5.5

XP_047304168.1

EC 3.6.5.5

XP_047304169.1

EC 3.6.5.5

XP_047304170.1

EC 3.6.5.5

XP_047304172.1

EC 3.6.5.5

XP_054202630.1

EC 3.6.5.5

XP_054202631.1

EC 3.6.5.5

XP_054202632.1

EC 3.6.5.5

XP_054202633.1

EC 3.6.5.5

XP_054202634.1

EC 3.6.5.5

XP_054202635.1

EC 3.6.5.5

XP_054202636.1

EC 3.6.5.5

XP_054202637.1

EC 3.6.5.5

XP_054202638.1

EC 3.6.5.5

XP_054202639.1

EC 3.6.5.5

XP_054202640.1

EC 3.6.5.5

XP_054202641.1

EC 3.6.5.5

XP_054202642.1

EC 3.6.5.5

XP_054202643.1

EC 3.6.5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011605.1 RefSeqGene

Range

5001..109668

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_337

mRNA and Protein(s)

NM_001354663.2 → NP_001341592.1 dynamin-like 120 kDa protein, mitochondrial isoform 9

Status: REVIEWED

Source sequence(s)

AC048351, AC106710

UniProtKB/TrEMBL

A0A2R8Y3X5

Conserved Domains (1) summary

cd08771
Location:164 → 438

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_001354664.2 → NP_001341593.1 dynamin-like 120 kDa protein, mitochondrial isoform 10

Status: REVIEWED

Source sequence(s)

AC048351, AC106710

UniProtKB/TrEMBL

A0A2R8Y3X5

Related

ENSP00000493673.1, ENST00000643329.1

Conserved Domains (1) summary

cd08771
Location:163 → 437

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_015560.3 → NP_056375.2 dynamin-like 120 kDa protein, mitochondrial isoform 1 preproprotein

See identical proteins and their annotated locations for NP_056375.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the original transcript identified. It contains 29 exons and encodes an isoform (1) of 960 aa.

Source sequence(s)

AC048351, AC106710

Consensus CDS

CCDS43186.1

UniProtKB/Swiss-Prot

D3DNW4, E5KLJ5, E5KLJ6, E5KLJ7, E5KLK1, E5KLK2, O60313

UniProtKB/TrEMBL

E5KLM2

Related

ENSP00000354429.3, ENST00000361828.7

Conserved Domains (1) summary

cd08771
Location:287 → 561

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_130831.3 → NP_570844.1 dynamin-like 120 kDa protein, mitochondrial isoform 2

See identical proteins and their annotated locations for NP_570844.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) is missing exon 4, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (2) of 924 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.

Source sequence(s)

AC048351, AC106710, BQ774938

Consensus CDS

CCDS87183.1

UniProtKB/TrEMBL

E5KLM2

Related

ENSP00000494512.1, ENST00000646793.1

Conserved Domains (1) summary

cd08771
Location:251 → 525

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_130832.3 → NP_570845.1 dynamin-like 120 kDa protein, mitochondrial isoform 3

See identical proteins and their annotated locations for NP_570845.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) is missing exon 4, but contains exon 4b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (3) of 942 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.

Source sequence(s)

AC048351, AC106710, BQ774938

UniProtKB/TrEMBL

E5KLK0, E5KLM2

Conserved Domains (1) summary

cd08771
Location:269 → 543

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_130833.3 → NP_570846.1 dynamin-like 120 kDa protein, mitochondrial isoform 4

See identical proteins and their annotated locations for NP_570846.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) is missing exon 4, but contains exon 5b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (4) of 961 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.

Source sequence(s)

AC048351, AC106710

UniProtKB/TrEMBL

E5KLM1

Related

ENSP00000354781.2, ENST00000361150.6

Conserved Domains (1) summary

cd08771
Location:288 → 562

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_130834.3 → NP_570847.2 dynamin-like 120 kDa protein, mitochondrial isoform 5 preproprotein

See identical proteins and their annotated locations for NP_570847.2

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an additional exon 4b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (5) of 978 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.

Source sequence(s)

AC048351, AC106710, BQ774938

UniProtKB/TrEMBL

E5KLM0

Related

ENSP00000376232.2, ENST00000392437.6

Conserved Domains (1) summary

cd08771
Location:305 → 579

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_130835.3 → NP_570848.1 dynamin-like 120 kDa protein, mitochondrial isoform 6

See identical proteins and their annotated locations for NP_570848.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) is missing exon 4, but contains exons 4b and 5b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (6) of 979 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.

Source sequence(s)

AC048351, AC106710

UniProtKB/TrEMBL

E5KLJ9, E5KLM1

Related

ENSP00000355311.2, ENST00000361715.6

Conserved Domains (1) summary

cd08771
Location:306 → 580

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_130836.3 → NP_570849.2 dynamin-like 120 kDa protein, mitochondrial isoform 7

See identical proteins and their annotated locations for NP_570849.2

Status: REVIEWED

Description

Transcript Variant: This variant (7) contains an additional exon 5b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (7) of 997 aa.

Source sequence(s)

AC048351, AC106710, BQ774938

Consensus CDS

CCDS33917.1

UniProtKB/TrEMBL

E5KLM1

Related

ENSP00000354681.3, ENST00000361908.8

Conserved Domains (1) summary

cd08771
Location:324 → 598

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_130837.3 → NP_570850.2 dynamin-like 120 kDa protein, mitochondrial isoform 8

See identical proteins and their annotated locations for NP_570850.2

Status: REVIEWED

Description

Transcript Variant: This variant (8) contains 2 additional exons, 4b and 5b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (8) of 1015 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.

Source sequence(s)

AC048351, AC106710

UniProtKB/TrEMBL

E5KLL9

Related

ENSP00000355324.2, ENST00000361510.8

Conserved Domains (1) summary

cd08771
Location:342 → 616

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

193593208..193697811

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448212.1 → XP_047304168.1 dynamin-like 120 kDa protein, mitochondrial isoform X7
XM_047448206.1 → XP_047304162.1 dynamin-like 120 kDa protein, mitochondrial isoform X1
XM_047448208.1 → XP_047304164.1 dynamin-like 120 kDa protein, mitochondrial isoform X3
XM_047448207.1 → XP_047304163.1 dynamin-like 120 kDa protein, mitochondrial isoform X2
XM_047448210.1 → XP_047304166.1 dynamin-like 120 kDa protein, mitochondrial isoform X5

Related

ENSP00000376231.3, ENST00000392436.7
XM_047448209.1 → XP_047304165.1 dynamin-like 120 kDa protein, mitochondrial isoform X4
XM_047448211.1 → XP_047304167.1 dynamin-like 120 kDa protein, mitochondrial isoform X6
XM_047448213.1 → XP_047304169.1 dynamin-like 120 kDa protein, mitochondrial isoform X8

Related

ENSP00000495943.1, ENST00000644959.1
XM_047448214.1 → XP_047304170.1 dynamin-like 120 kDa protein, mitochondrial isoform X9
XM_047448216.1 → XP_047304172.1 dynamin-like 120 kDa protein, mitochondrial isoform X10

Related

ENSP00000495028.1, ENST00000646544.1

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

196288807..196394453

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054346660.1 → XP_054202635.1 dynamin-like 120 kDa protein, mitochondrial isoform X4
XM_054346655.1 → XP_054202630.1 dynamin-like 120 kDa protein, mitochondrial isoform X1
XM_054346666.1 → XP_054202641.1 dynamin-like 120 kDa protein, mitochondrial isoform X7
XM_054346658.1 → XP_054202633.1 dynamin-like 120 kDa protein, mitochondrial isoform X3
XM_054346664.1 → XP_054202639.1 dynamin-like 120 kDa protein, mitochondrial isoform X6
XM_054346656.1 → XP_054202631.1 dynamin-like 120 kDa protein, mitochondrial isoform X2
XM_054346661.1 → XP_054202636.1 dynamin-like 120 kDa protein, mitochondrial isoform X5
XM_054346657.1 → XP_054202632.1 dynamin-like 120 kDa protein, mitochondrial isoform X11
XM_054346662.1 → XP_054202637.1 dynamin-like 120 kDa protein, mitochondrial isoform X13
XM_054346659.1 → XP_054202634.1 dynamin-like 120 kDa protein, mitochondrial isoform X12
XM_054346663.1 → XP_054202638.1 dynamin-like 120 kDa protein, mitochondrial isoform X14
XM_054346665.1 → XP_054202640.1 dynamin-like 120 kDa protein, mitochondrial isoform X15
XM_054346667.1 → XP_054202642.1 dynamin-like 120 kDa protein, mitochondrial isoform X8
XM_054346668.1 → XP_054202643.1 dynamin-like 120 kDa protein, mitochondrial isoform X10