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    INPP5K inositol polyphosphate-5-phosphatase K [ Homo sapiens (human) ]

    Gene ID: 51763, updated on 5-Mar-2024

    Summary

    Official Symbol
    INPP5Kprovided by HGNC
    Official Full Name
    inositol polyphosphate-5-phosphatase Kprovided by HGNC
    Primary source
    HGNC:HGNC:33882
    See related
    Ensembl:ENSG00000132376 MIM:607875; AllianceGenome:HGNC:33882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PPS; SKIP; MDCCAID
    Summary
    This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
    Expression
    Ubiquitous expression in fat (RPKM 17.9), lung (RPKM 14.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    17p13.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (1494577..1516612, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (1383334..1405368, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1397871..1419906, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1335344-1335844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1335845-1336345 Neighboring gene Sharpr-MPRA regulatory region 4720 Neighboring gene CRK proto-oncogene, adaptor protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1357059-1357560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1358695-1359680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11449 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1366499-1367318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1371831-1372451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11451 Neighboring gene myosin IC Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7957 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1394312-1395031 Neighboring gene uncharacterized LOC105371483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7960 Neighboring gene PITPNA antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1437952-1438452 Neighboring gene phosphatidylinositol transfer protein alpha Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:1445478-1446238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1453921-1454835 Neighboring gene MPRA-validated peak2674 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1463158-1464124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7962 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:1465907-1466406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1474719-1475554 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1478810-1479622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1479623-1480434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1480435-1481246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1481247-1482057 Neighboring gene solute carrier family 43 member 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1488375-1488922 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1488923-1489468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1489469-1490015 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1490016-1490561 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1490562-1491108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1491109-1491655 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1493297-1493842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1493843-1494388 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:1495156-1495321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1496929-1497430 Neighboring gene RNA, 7SL, cytoplasmic 105, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables inositol bisphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol bisphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol trisphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol-polyphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid phosphatase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables phosphatidylinositol phosphate 5-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphatidylinositol trisphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity TAS
    Traceable Author Statement
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables vasopressin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to cAMP ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to epidermal growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hormone stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation by host of viral transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glycogen (starch) synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of glycogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of renal water transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of urine volume ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of glycogen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ruffle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inositol polyphosphate 5-phosphatase K
    Names
    phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase
    skeletal muscle and kidney-enriched inositol phosphatase
    NP_001129114.1
    NP_057616.2
    NP_570122.1
    XP_011522236.1
    XP_024306570.1
    XP_047292250.1
    XP_054172472.1
    XP_054172473.1
    XP_054172474.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029891.1 RefSeqGene

      Range
      5277..27312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135642.2NP_001129114.1  inositol polyphosphate 5-phosphatase K isoform 2

      See identical proteins and their annotated locations for NP_001129114.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional segment in its 5' end, as compared to variant 1. The resulting isoform, isoform 2, has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform, isoform 2.
      Source sequence(s)
      AB036829, AC100748, BC004362, BM510617
      Consensus CDS
      CCDS11005.1
      UniProtKB/Swiss-Prot
      Q9BT40
      Related
      ENSP00000385177.4, ENST00000406424.8
      Conserved Domains (1) summary
      cl00490
      Location:1244
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    2. NM_016532.4NP_057616.2  inositol polyphosphate 5-phosphatase K isoform 1

      See identical proteins and their annotated locations for NP_057616.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform of this protein.
      Source sequence(s)
      AB036829, AC100748, BC004362, BM510617
      Consensus CDS
      CCDS11004.1
      UniProtKB/Swiss-Prot
      B2R6I2, B2R750, D3DTH8, Q15733, Q9BT40, Q9NPJ5, Q9P2R5
      Related
      ENSP00000413937.2, ENST00000421807.7
      Conserved Domains (2) summary
      pfam17751
      Location:331431
      SKICH; SKICH domain
      cl00490
      Location:14320
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    3. NM_130766.3NP_570122.1  inositol polyphosphate 5-phosphatase K isoform 2

      See identical proteins and their annotated locations for NP_570122.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional segment in its 5' end, as compared to variant 1. The resulting isoform, isoform 2, has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform, isoform 2.
      Source sequence(s)
      AB036829, AC100748, BC004362, BM510617
      Consensus CDS
      CCDS11005.1
      UniProtKB/Swiss-Prot
      Q9BT40
      Related
      ENSP00000318476.6, ENST00000320345.10
      Conserved Domains (1) summary
      cl00490
      Location:1244
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      1494577..1516612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436294.1XP_047292250.1  inositol polyphosphate 5-phosphatase K isoform X2

      UniProtKB/TrEMBL
      B7Z4V9
    2. XM_024450802.2XP_024306570.1  inositol polyphosphate 5-phosphatase K isoform X1

      Conserved Domains (1) summary
      cl00490
      Location:1244
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    3. XM_011523934.2XP_011522236.1  inositol polyphosphate 5-phosphatase K isoform X1

      See identical proteins and their annotated locations for XP_011522236.1

      UniProtKB/Swiss-Prot
      Q9BT40
      Conserved Domains (1) summary
      cl00490
      Location:1244
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      1383334..1405368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316499.1XP_054172474.1  inositol polyphosphate 5-phosphatase K isoform X2

      UniProtKB/TrEMBL
      B7Z4V9
    2. XM_054316498.1XP_054172473.1  inositol polyphosphate 5-phosphatase K isoform X1

    3. XM_054316497.1XP_054172472.1  inositol polyphosphate 5-phosphatase K isoform X1