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    CDK10 cyclin dependent kinase 10 [ Homo sapiens (human) ]

    Gene ID: 8558, updated on 6-Jun-2024

    Summary

    Official Symbol
    CDK10provided by HGNC
    Official Full Name
    cyclin dependent kinase 10provided by HGNC
    Primary source
    HGNC:HGNC:1770
    See related
    Ensembl:ENSG00000185324 MIM:603464; AllianceGenome:HGNC:1770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALSAS; PISSLRE
    Summary
    The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
    Expression
    Ubiquitous expression in duodenum (RPKM 16.8), thyroid (RPKM 15.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CDK10 in Genome Data Viewer
    Location:
    16q24.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89686689..89696354)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (95771455..95781117)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89753097..89762762)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903758 Neighboring gene charged multivesicular body protein 1A Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_46628 and experimental_46635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7918 Neighboring gene spermatogenesis associated 33 Neighboring gene MPRA-validated peak2666 silencer Neighboring gene long intergenic non-protein coding RNA 2166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89765851-89766716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7920 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7921 Neighboring gene spermatogenesis associated 2 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89772795-89773295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89777095-89777658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11419 Neighboring gene VPS9 domain containing 1 Neighboring gene VPS9D1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Al Kaissi syndrome
    MedGen: C4540156 OMIM: 617694 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
    EBI GWAS Catalog
    Genome-wide association study identifies three loci associated with melanoma risk.
    EBI GWAS Catalog
    Genome-wide association study identifies three new melanoma susceptibility loci.
    EBI GWAS Catalog
    Identification of a melanoma susceptibility locus and somatic mutation in TET2.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat FITC-labeled Tat 47-59 peptide downregulates gene expression of cyclin-dependent kinase 10 (CDK10) in U-937 macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-dependent kinase 10
    Names
    CDC2-related protein kinase
    cell division protein kinase 10
    cyclin-dependent kinase (CDC2-like) 10
    cyclin-dependent kinase related protein
    serine/threonine protein kinase PISSLRE
    NP_001092003.2
    NP_001153839.1
    NP_443713.2
    NP_443714.3
    XP_006721371.1
    XP_006721373.1
    XP_011521707.1
    XP_011521708.1
    XP_011521709.1
    XP_011521710.1
    XP_011521712.1
    XP_011521715.1
    XP_011521717.1
    XP_011521719.1
    XP_016879295.1
    XP_016879296.1
    XP_016879299.1
    XP_047290776.1
    XP_047290777.1
    XP_047290778.1
    XP_047290779.1
    XP_047290780.1
    XP_047290781.1
    XP_054170201.1
    XP_054170202.1
    XP_054170203.1
    XP_054170204.1
    XP_054170205.1
    XP_054170206.1
    XP_054170207.1
    XP_054170208.1
    XP_054170209.1
    XP_054170210.1
    XP_054170211.1
    XP_054170212.1
    XP_054170213.1
    XP_054170214.1
    XP_054170215.1
    XP_054170216.1
    XP_054170217.1
    XP_054170218.1
    XP_054170219.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098533.3NP_001092003.2  cyclin-dependent kinase 10 isoform c

      See identical proteins and their annotated locations for NP_001092003.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) uses an alternate donor splice site at the first exon resulting in translation from a downstream start codon, and uses an alternate donor splice site in the 3' coding region, compared to variant a. The resulting isoform (c) has a shorter N-terminus and lacks a 6-aa segment near the C-terminus, compared to isoform a.
      Source sequence(s)
      BC017342
      UniProtKB/TrEMBL
      F8W872
      Conserved Domains (1) summary
      cl21453
      Location:1262
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001160367.2NP_001153839.1  cyclin-dependent kinase 10 isoform d

      See identical proteins and their annotated locations for NP_001153839.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) uses an alternate donor splice site at the first exon resulting in translation from downstream start codon, compared to variant a. The resulting isoform (d) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC010538, AK298386, BC017342
      UniProtKB/TrEMBL
      F8W872
      Conserved Domains (1) summary
      cd07845
      Location:1268
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    3. NM_052987.4NP_443713.2  cyclin-dependent kinase 10 isoform b

      See identical proteins and their annotated locations for NP_443713.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) uses an alternate donor splice site at the first exon resulting in translation from a downstream start codon, and uses an alternate acceptor splice site at the last exon, compared to variant a. The resulting isoform (b) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BC017342, L33264
      Consensus CDS
      CCDS32514.2
      UniProtKB/TrEMBL
      F8W872
      Related
      ENSP00000424415.1, ENST00000505473.5
      Conserved Domains (1) summary
      cl21453
      Location:1257
      PKc_like; Protein Kinases, catalytic domain
    4. NM_052988.5NP_443714.3  cyclin-dependent kinase 10 isoform a

      See identical proteins and their annotated locations for NP_443714.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK298386, BC017342
      Consensus CDS
      CCDS10984.2
      UniProtKB/Swiss-Prot
      A8K370, A8K8I6, A8MXU6, B3KQJ3, B7Z420, D3DX82, D3DX83, Q0VGZ7, Q15130, Q15131, Q6PJC0
      UniProtKB/TrEMBL
      B7Z537
      Related
      ENSP00000338673.7, ENST00000353379.12
      Conserved Domains (1) summary
      cd07845
      Location:31339
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

    RNA

    1. NR_027702.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) lacks the second exon, compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK296631, AK298386, BC017342
      Related
      ENST00000510811.6
    2. NR_027703.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant (f) lacks the second exon and uses an alternate acceptor splice site at the last exon, compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK298386, BC025301

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      89686689..89696354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523405.4XP_011521707.1  cyclin-dependent kinase 10 isoform X1

      UniProtKB/TrEMBL
      B7Z537
      Conserved Domains (2) summary
      cd07845
      Location:31371
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
      PTZ00024
      Location:43368
      PTZ00024; cyclin-dependent protein kinase; Provisional
    2. XM_011523407.4XP_011521709.1  cyclin-dependent kinase 10 isoform X3

      UniProtKB/TrEMBL
      B7Z537
      Conserved Domains (2) summary
      cd07845
      Location:31360
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
      PTZ00024
      Location:43360
      PTZ00024; cyclin-dependent protein kinase; Provisional
    3. XM_011523406.4XP_011521708.1  cyclin-dependent kinase 10 isoform X2

      UniProtKB/TrEMBL
      B7Z537
      Conserved Domains (2) summary
      cd07845
      Location:31365
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
      PTZ00024
      Location:43362
      PTZ00024; cyclin-dependent protein kinase; Provisional
    4. XM_011523408.4XP_011521710.1  cyclin-dependent kinase 10 isoform X4

      UniProtKB/TrEMBL
      B7Z537
      Conserved Domains (2) summary
      cd07845
      Location:31354
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
      PTZ00024
      Location:43354
      PTZ00024; cyclin-dependent protein kinase; Provisional
    5. XM_006721310.4XP_006721373.1  cyclin-dependent kinase 10 isoform X7

      UniProtKB/TrEMBL
      B7Z537
      Related
      ENST00000505733.5
      Conserved Domains (2) summary
      cd07845
      Location:31328
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
      PLN00009
      Location:38325
      PLN00009; cyclin-dependent kinase A; Provisional
    6. XM_006721308.4XP_006721371.1  cyclin-dependent kinase 10 isoform X6

      UniProtKB/TrEMBL
      B7Z537
      Conserved Domains (1) summary
      cd07845
      Location:31333
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    7. XM_017023807.3XP_016879296.1  cyclin-dependent kinase 10 isoform X9

      UniProtKB/TrEMBL
      B7Z537
    8. XM_011523415.3XP_011521717.1  cyclin-dependent kinase 10 isoform X11

      See identical proteins and their annotated locations for XP_011521717.1

      UniProtKB/TrEMBL
      F8W872
      Conserved Domains (1) summary
      cd07845
      Location:1300
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    9. XM_011523410.3XP_011521712.1  cyclin-dependent kinase 10 isoform X11

      See identical proteins and their annotated locations for XP_011521712.1

      UniProtKB/TrEMBL
      F8W872
      Conserved Domains (1) summary
      cd07845
      Location:1300
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    10. XM_017023806.2XP_016879295.1  cyclin-dependent kinase 10 isoform X5

      UniProtKB/TrEMBL
      F8W872
      Conserved Domains (2) summary
      cd07845
      Location:16334
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
      PTZ00024
      Location:16331
      PTZ00024; cyclin-dependent protein kinase; Provisional
    11. XM_047434820.1XP_047290776.1  cyclin-dependent kinase 10 isoform X8

      UniProtKB/TrEMBL
      F8W872
    12. XM_047434821.1XP_047290777.1  cyclin-dependent kinase 10 isoform X10

      UniProtKB/TrEMBL
      F8W872
      Related
      ENSP00000329957.8, ENST00000331006.12
    13. XM_047434825.1XP_047290781.1  cyclin-dependent kinase 10 isoform X13

      UniProtKB/TrEMBL
      F8W872
    14. XM_047434824.1XP_047290780.1  cyclin-dependent kinase 10 isoform X12

      UniProtKB/TrEMBL
      F8W872
    15. XM_011523417.4XP_011521719.1  cyclin-dependent kinase 10 isoform X15

      Conserved Domains (2) summary
      smart00220
      Location:39225
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:31223
      PKc_like; Protein Kinases, catalytic domain
    16. XM_017023810.2XP_016879299.1  cyclin-dependent kinase 10 isoform X14

      UniProtKB/TrEMBL
      F8W872
      Conserved Domains (1) summary
      cl21453
      Location:1257
      PKc_like; Protein Kinases, catalytic domain
    17. XM_011523413.3XP_011521715.1  cyclin-dependent kinase 10 isoform X11

      See identical proteins and their annotated locations for XP_011521715.1

      UniProtKB/TrEMBL
      F8W872
      Conserved Domains (1) summary
      cd07845
      Location:1300
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    18. XM_047434822.1XP_047290778.1  cyclin-dependent kinase 10 isoform X11

      UniProtKB/TrEMBL
      F8W872
    19. XM_047434823.1XP_047290779.1  cyclin-dependent kinase 10 isoform X11

      UniProtKB/TrEMBL
      F8W872

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      95771455..95781117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314226.1XP_054170201.1  cyclin-dependent kinase 10 isoform X1

      UniProtKB/TrEMBL
      B7Z537
    2. XM_054314228.1XP_054170203.1  cyclin-dependent kinase 10 isoform X3

      UniProtKB/TrEMBL
      B7Z537
    3. XM_054314227.1XP_054170202.1  cyclin-dependent kinase 10 isoform X2

      UniProtKB/TrEMBL
      B7Z537
    4. XM_054314229.1XP_054170204.1  cyclin-dependent kinase 10 isoform X4

      UniProtKB/TrEMBL
      B7Z537
    5. XM_054314232.1XP_054170207.1  cyclin-dependent kinase 10 isoform X7

      UniProtKB/TrEMBL
      B7Z537
    6. XM_054314231.1XP_054170206.1  cyclin-dependent kinase 10 isoform X6

      UniProtKB/TrEMBL
      B7Z537
    7. XM_054314234.1XP_054170209.1  cyclin-dependent kinase 10 isoform X9

      UniProtKB/TrEMBL
      B7Z537
    8. XM_054314239.1XP_054170214.1  cyclin-dependent kinase 10 isoform X11

      UniProtKB/TrEMBL
      F8W872
    9. XM_054314236.1XP_054170211.1  cyclin-dependent kinase 10 isoform X11

      UniProtKB/TrEMBL
      F8W872
    10. XM_054314230.1XP_054170205.1  cyclin-dependent kinase 10 isoform X5

      UniProtKB/TrEMBL
      F8W872
    11. XM_054314233.1XP_054170208.1  cyclin-dependent kinase 10 isoform X8

      UniProtKB/TrEMBL
      F8W872
    12. XM_054314235.1XP_054170210.1  cyclin-dependent kinase 10 isoform X10

      UniProtKB/TrEMBL
      F8W872
    13. XM_054314242.1XP_054170217.1  cyclin-dependent kinase 10 isoform X13

      UniProtKB/TrEMBL
      F8W872
    14. XM_054314241.1XP_054170216.1  cyclin-dependent kinase 10 isoform X12

      UniProtKB/TrEMBL
      F8W872
    15. XM_054314244.1XP_054170219.1  cyclin-dependent kinase 10 isoform X15

    16. XM_054314243.1XP_054170218.1  cyclin-dependent kinase 10 isoform X14

      UniProtKB/TrEMBL
      F8W872
    17. XM_054314238.1XP_054170213.1  cyclin-dependent kinase 10 isoform X11

      UniProtKB/TrEMBL
      F8W872
    18. XM_054314237.1XP_054170212.1  cyclin-dependent kinase 10 isoform X11

      UniProtKB/TrEMBL
      F8W872
    19. XM_054314240.1XP_054170215.1  cyclin-dependent kinase 10 isoform X11

      UniProtKB/TrEMBL
      F8W872

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_003674.2: Suppressed sequence

      Description
      NM_003674.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.