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    DNM2 dynamin 2 [ Homo sapiens (human) ]

    Gene ID: 1785, updated on 4-Feb-2024

    Summary

    Official Symbol
    DNM2provided by HGNC
    Official Full Name
    dynamin 2provided by HGNC
    Primary source
    HGNC:HGNC:2974
    See related
    Ensembl:ENSG00000079805 MIM:602378; AllianceGenome:HGNC:2974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DYN2; CMT2M; DYNII; LCCS5; CMTDI1; CMTDIB; DI-CMTB
    Summary
    Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in colon (RPKM 49.5), stomach (RPKM 41.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DNM2 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10718079..10831903)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10844675..10958914)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10828755..10942579)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10087 Neighboring gene interleukin enhancer binding factor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10801737-10802532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10802533-10803326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10806023-10806522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10811832-10812580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13985 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10826293-10826482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13988 Neighboring gene queuine tRNA-ribosyltransferase catalytic subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13989 Neighboring gene microRNA 638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10859277-10860091 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10861227-10861848 Neighboring gene uncharacterized LOC124904637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13993 Neighboring gene microRNA 4748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10922359-10923291 Neighboring gene microRNA 199a-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10945386-10946023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10946661-10947297 Neighboring gene microRNA 6793 Neighboring gene chromosome 19 open reading frame 38 Neighboring gene HIKESHI pseudogene 2 Neighboring gene transmembrane p24 trafficking protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 replication requires DNM2 expression; knockdown through shRNA expression decreased viral replication in monocyte derived dendritic cell and CD4+ T cell mixed cultures PubMed
    Knockdown of dynamin 2 (DNM2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
    Knockdown of dynamin 2 by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Envelope transmembrane glycoprotein gp41 env The cytoplasmic tail, in particular amino acids 718-723, of HIV-1 gp41 is an important determinant for dynasore (a dynamin inhibitor) sensitivity in HIV-mediated cell-cell fusion PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    nef Dyn2 is required for the infectivity enhancement function of Nef. The K44A mutant of Dyn2 markedly reduces the infectivity of nef-positive HIV PubMed
    nef Nef specifically interacts with dynamin 2 (Dyn2) in an in vitro pull-down assay. The middle domain and the GED of Dyn2 are both necessary and together confer full Nef binding while the myristyl moiety of Nef is critical for the interaction with Dyn2 PubMed
    nef HIV-1 Nef enhances the infectivity of CD4-chemokine receptor-pseudotyped HIV-1 for target cells expressing HIV-1 Env. Virus-producing cells expressing dominant-negative dynamin 2 (K44A) selectively inhibits these receptor-pseudotyped virions PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag Dynamin-dependent endocytosis is required for intracellular accumulation of HIV-1 Gag in the presence of HLA-DR PubMed
    gag HIV-1 Gag co-localizes with dynamin in primary T lymphocytes PubMed
    Vpu vpu Dominant negative dynamin 2 (K44A) acts as an inhibitor of clathrin-mediated endocytosis and inhibits the downregulation of BST-2 from the cell surface by HIV-1 Vpu PubMed
    capsid gag Dynamin 2 depletion by shRNA results in inhibition of the HIV-1 CA uptake by target cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein self-association ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in actin filament bundle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament bundle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
    Traceable Author Statement
    more info
     
    involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in membrane organization TAS
    Traceable Author Statement
    more info
     
    involved_in membrane tubulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membrane tubulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of membrane tubulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in post-Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    involved_in protein polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in transferrin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle scission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    colocalizes_with growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in phagocytic cup IEA
    Inferred from Electronic Annotation
    more info
     
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in uropod IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dynamin-2
    Names
    dynamin II
    NP_001005360.1
    NP_001005361.1
    NP_001005362.1
    NP_001177645.1
    NP_004936.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008792.1 RefSeqGene

      Range
      4975..118832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_238

    mRNA and Protein(s)

    1. NM_001005360.3NP_001005360.1  dynamin-2 isoform 1

      See identical proteins and their annotated locations for NP_001005360.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes one of the longer isoforms (1).
      Source sequence(s)
      AC011475, AC011552, AC112707, BC039596, BC054501, BU621654
      Consensus CDS
      CCDS45968.1
      UniProtKB/Swiss-Prot
      A8K1B6, E7EV30, E9PEQ4, K7ESI9, P50570, Q5I0Y0, Q7Z5S3, Q9UPH4
      Related
      ENSP00000347890.6, ENST00000355667.11
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      PHA03247
      Location:737868
      PHA03247; large tegument protein UL36; Provisional
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651739
      GED; Dynamin GTPase effector domain
    2. NM_001005361.3NP_001005361.1  dynamin-2 isoform 2

      See identical proteins and their annotated locations for NP_001005361.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is the same length as isoform 1 but differs in an internal region, compared to isoform 1.
      Source sequence(s)
      AC011475, AC011552, AC112707, AK097875, BC039596
      Consensus CDS
      CCDS45969.1
      UniProtKB/Swiss-Prot
      P50570
      UniProtKB/TrEMBL
      Q8N1K8
      Related
      ENSP00000373905.4, ENST00000389253.9
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      PHA03247
      Location:737868
      PHA03247; large tegument protein UL36; Provisional
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651739
      GED; Dynamin GTPase effector domain
    3. NM_001005362.3NP_001005362.1  dynamin-2 isoform 4

      See identical proteins and their annotated locations for NP_001005362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 4) is shorter, compared to isoform 1.
      Source sequence(s)
      AC011475, AC011552, AC112707, AK289831, BC039596, BU621654
      Consensus CDS
      CCDS32908.1
      UniProtKB/Swiss-Prot
      P50570
      Related
      ENSP00000386192.3, ENST00000408974.8
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      PHA03247
      Location:733864
      PHA03247; large tegument protein UL36; Provisional
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:647735
      GED; Dynamin GTPase effector domain
    4. NM_001190716.2NP_001177645.1  dynamin-2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks 3 nts at an alternate splice site, compared to variant 1. The resulting protein (isoform 5) lacks one aa in the C-terminus, compared to isoform 1.
      Source sequence(s)
      AK312260, BC039596, BU621654
      Consensus CDS
      CCDS59351.1
      UniProtKB/Swiss-Prot
      P50570
      Related
      ENSP00000468734.1, ENST00000585892.5
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      PRK14951
      Location:745865
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651739
      GED; Dynamin GTPase effector domain
    5. NM_004945.4NP_004936.2  dynamin-2 isoform 3

      See identical proteins and their annotated locations for NP_004936.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC011475, AC011552, AC112707, BC054501, BU621654
      Consensus CDS
      CCDS32907.1
      UniProtKB/Swiss-Prot
      P50570
      Related
      ENSP00000352721.6, ENST00000359692.10
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      PHA03247
      Location:733864
      PHA03247; large tegument protein UL36; Provisional
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:647735
      GED; Dynamin GTPase effector domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10718079..10831903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10844675..10958914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)