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    MAPT microtubule associated protein tau [ Homo sapiens (human) ]

    Gene ID: 4137, updated on 22-Feb-2024

    Summary

    Official Symbol
    MAPTprovided by HGNC
    Official Full Name
    microtubule associated protein tauprovided by HGNC
    Primary source
    HGNC:HGNC:6893
    See related
    Ensembl:ENSG00000186868 MIM:157140; AllianceGenome:HGNC:6893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103; Tau-PHF6
    Summary
    This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 70.2), kidney (RPKM 12.0) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAPT in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (45894554..46028334)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (46756177..46889953)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43971920..44105700)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene LINC02210-CRHR1 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43862413-43862913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43869433-43869933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43883739-43884240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43884241-43884740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43890849-43891705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43900915-43901416 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43917814-43918023 Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43922169-43923153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43923154-43924137 Neighboring gene MAPT antisense RNA 1 Neighboring gene signal peptide peptidase like 2C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43971863-43972748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43972749-43973634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43974521-43975405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43983393-43983892 Neighboring gene uncharacterized LOC105371800 Neighboring gene MAPT intronic transcript 1 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr17:44019777-44020277 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:44066175-44066366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44070003-44070564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44086993-44087496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44100868-44101486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44102104-44102721 Neighboring gene saitohin Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene MPRA-validated peak2868 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44225973-44226474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44226475-44226974 Neighboring gene uncharacterized LOC107985027 Neighboring gene KANSL1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-05-08)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-05-08)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
    EBI GWAS Catalog
    Common variants at 12q15 and 12q24 are associated with infant head circumference.
    EBI GWAS Catalog
    Common variants at 6q22 and 17q21 are associated with intracranial volume.
    EBI GWAS Catalog
    Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.
    EBI GWAS Catalog
    Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
    EBI GWAS Catalog
    Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
    EBI GWAS Catalog
    Genome-wide association study reveals genetic risk underlying Parkinson's disease.
    EBI GWAS Catalog
    Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    EBI GWAS Catalog
    Identification of a novel Parkinson's disease locus via stratified genome-wide association study.
    EBI GWAS Catalog
    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
    EBI GWAS Catalog
    Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog
    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
    EBI GWAS Catalog
    Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat increases cellular amounts of phosphorylated MAPT (Tau); increases are dependent upon Tat amino acids 31-61 and can be inhibited by caffeine PubMed
    tat HIV-1 Tat induces hyperphosphorylation of Tau PubMed
    tat HIV-1 Tat induces hyperphosphorylation of Tau in neuronal cells PubMed
    tat Treatment of microglia cells with HIV-1 Tat shows TAU5 and synapsin-1 positive inclusions in cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ31424, MGC138549

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables Hsp90 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables apolipoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables double-stranded DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables dynactin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables histone-dependent DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipoprotein particle binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables microtubule binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables microtubule binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables microtubule lateral binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables minor groove of adenine-thymine-rich DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables phosphatidylinositol binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables phosphatidylinositol bisphosphate binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein phosphatase 2A binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables single-stranded DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in amyloid fibril formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in astrocyte activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in axon development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in axonal transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in axonal transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in axonal transport of mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to brain-derived neurotrophic factor stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to heat TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to nerve growth factor stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to reactive oxygen species TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in central nervous system neuron development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cytoplasmic microtubule organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in generation of neurons NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in internal protein amino acid acetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intracellular distribution of mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microglial cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in microtubule polymerization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of establishment of protein localization to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of tubulin deacetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of tubulin deacetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neurofibrillary tangle assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in plus-end-directed organelle transport along microtubule TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of axon extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of diacylglycerol kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of superoxide anion generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rRNA metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of autophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of chromosome organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of long-term synaptic depression TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of microtubule cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of microtubule polymerization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of microtubule polymerization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of microtubule polymerization or depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitochondrial fission IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of synaptic plasticity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to lead ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stress granule assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in supramolecular fiber organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in supramolecular fiber organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in axon TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in glial cell projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in main axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule cytoskeleton NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in neurofibrillary tangle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neurofibrillary tangle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in somatodendritic compartment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in somatodendritic compartment TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of tubulin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    microtubule-associated protein tau
    Names
    G protein beta1/gamma2 subunit-interacting factor 1
    PHF-tau
    Tau-derived paired helical filament hexapeptide
    neurofibrillary tangle protein
    paired helical filament-tau
    protein phosphatase 1, regulatory subunit 103

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007398.2 RefSeqGene

      Range
      5092..138872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_660

    mRNA and Protein(s)

    1. NM_001123066.4NP_001116538.2  microtubule-associated protein tau isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes the longest isoform (6).
      Source sequence(s)
      AW295014, BN000503, CR936218, DN996935
      Consensus CDS
      CCDS45715.1
      UniProtKB/TrEMBL
      A0A0G2JMX7
      Related
      ENSP00000410838.2, ENST00000415613.6
      Conserved Domains (1) summary
      pfam00418
      Location:610639
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    2. NM_001123067.4NP_001116539.1  microtubule-associated protein tau isoform 5

      See identical proteins and their annotated locations for NP_001116539.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks four internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (5) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
      Source sequence(s)
      BC114948, CR936218, DN996935
      Consensus CDS
      CCDS45716.1
      UniProtKB/TrEMBL
      A0A7P0T936
      Related
      ENSP00000413056.2, ENST00000420682.7
      Conserved Domains (2) summary
      PHA03307
      Location:27233
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:246275
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    3. NM_001203251.2NP_001190180.1  microtubule-associated protein tau isoform 7

      See identical proteins and their annotated locations for NP_001190180.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks four internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (7) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
      Source sequence(s)
      AK095802, CR936218, DN996935
      Consensus CDS
      CCDS92347.1
      UniProtKB/TrEMBL
      A0A7P0T936, I3L170
      Related
      ENSP00000443028.2, ENST00000535772.6
      Conserved Domains (1) summary
      pfam00418
      Location:246275
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    4. NM_001203252.2NP_001190181.1  microtubule-associated protein tau isoform 8

      See identical proteins and their annotated locations for NP_001190181.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks three internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (8) has identical N- and C-termini but lacks three segments, as compared to isoform 6.
      Source sequence(s)
      AK095802, BN000503, CR936218, DN996935
      Consensus CDS
      CCDS56033.1
      UniProtKB/TrEMBL
      A0A7P0T936
      Related
      ENSP00000389250.3, ENST00000431008.7
      Conserved Domains (1) summary
      pfam00418
      Location:275305
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    5. NM_001377265.1NP_001364194.1  microtubule-associated protein tau isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC217771, CR936218
      Consensus CDS
      CCDS92345.1
      UniProtKB/TrEMBL
      A0A0G2JPD5, A0A7I2PJZ2
      Related
      ENSP00000262410.6, ENST00000262410.10
      Conserved Domains (2) summary
      PHA03247
      Location:217645
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:667696
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    6. NM_001377266.1NP_001364195.1  microtubule-associated protein tau isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC217771, CR936218
      Consensus CDS
      CCDS92346.1
      UniProtKB/TrEMBL
      A0A0G2JPD5, A0A7I2PLE3
      Related
      ENSP00000340820.6, ENST00000344290.10
      Conserved Domains (2) summary
      PHA03247
      Location:217564
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:601631
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    7. NM_001377267.1NP_001364196.1  microtubule-associated protein tau isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC217771, CR936218
      Conserved Domains (2) summary
      PHA03307
      Location:27233
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:223245
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    8. NM_001377268.1NP_001364197.1  microtubule-associated protein tau isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC217771, CR936218
      Consensus CDS
      CCDS11502.1
      UniProtKB/TrEMBL
      I3L170
      Conserved Domains (1) summary
      pfam00418
      Location:217247
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    9. NM_005910.6NP_005901.2  microtubule-associated protein tau isoform 2

      See identical proteins and their annotated locations for NP_005901.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (2) has identical N- and C-termini but lacks three segments, as compared to isoform 6.
      Source sequence(s)
      BN000503, CR936218, DN996935, X14474
      Consensus CDS
      CCDS11499.1
      UniProtKB/TrEMBL
      A0A7P0T936
      Related
      ENSP00000303214.7, ENST00000351559.10
      Conserved Domains (1) summary
      pfam00418
      Location:275304
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    10. NM_016834.5NP_058518.1  microtubule-associated protein tau isoform 3

      See identical proteins and their annotated locations for NP_058518.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks five internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (3) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
      Source sequence(s)
      BC114948, CR936218, DN996935
      Consensus CDS
      CCDS11500.1
      UniProtKB/TrEMBL
      A0A7P0T936
      Related
      ENSP00000408975.3, ENST00000446361.7
      Conserved Domains (1) summary
      pfam00418
      Location:217246
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    11. NM_016835.5NP_058519.3  microtubule-associated protein tau isoform 1

      See identical proteins and their annotated locations for NP_058519.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks one internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (1) has identical N- and C-termini but lacks one segment, as compared to isoform 6.
      Source sequence(s)
      AW295014, BC114948, BN000503, CR936218, DN996935
      Consensus CDS
      CCDS11501.1
      UniProtKB/Swiss-Prot
      P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q1RMF6, Q53YB1, Q5CZI7, Q5XWF0, Q6QT54, Q9UDJ3, Q9UMH0, Q9UQ96
      UniProtKB/TrEMBL
      A0A0G2JPD5
      Related
      ENSP00000458742.1, ENST00000571987.5
      Conserved Domains (1) summary
      pfam00418
      Location:592621
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    12. NM_016841.5NP_058525.1  microtubule-associated protein tau isoform 4

      See identical proteins and their annotated locations for NP_058525.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks six internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (4) has identical N- and C-termini but lacks five segments, as compared to isoform 6.
      Source sequence(s)
      BC000558, CR936218, DN996935
      Consensus CDS
      CCDS11502.1
      UniProtKB/TrEMBL
      I3L170
      Related
      ENSP00000334886.8, ENST00000334239.12
      Conserved Domains (1) summary
      pfam00418
      Location:217247
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    RNA

    1. NR_165166.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC217771, CR936218

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      45894554..46028334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257362.5XP_005257419.1  microtubule-associated protein tau isoform X1

      UniProtKB/TrEMBL
      A0A0G2JPD5
      Conserved Domains (1) summary
      pfam00418
      Location:696725
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    2. XM_005257365.5XP_005257422.1  microtubule-associated protein tau isoform X2

      UniProtKB/TrEMBL
      A0A0G2JPD5
      Conserved Domains (1) summary
      pfam00418
      Location:696725
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    3. XM_005257367.5XP_005257424.1  microtubule-associated protein tau isoform X5

      UniProtKB/TrEMBL
      A0A0G2JPD5
      Conserved Domains (1) summary
      pfam00418
      Location:630659
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    4. XM_005257368.5XP_005257425.1  microtubule-associated protein tau isoform X8

      UniProtKB/TrEMBL
      A0A0G2JPD5
      Conserved Domains (1) summary
      pfam00418
      Location:630659
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    5. XM_005257369.5XP_005257426.1  microtubule-associated protein tau isoform X11

      Conserved Domains (1) summary
      pfam00418
      Location:341370
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    6. XM_047436079.1XP_047292035.1  microtubule-associated protein tau isoform X13

    7. XM_047436074.1XP_047292030.1  microtubule-associated protein tau isoform X4

      UniProtKB/TrEMBL
      A0A0G2JPD5
    8. XM_047436076.1XP_047292032.1  microtubule-associated protein tau isoform X7

      UniProtKB/TrEMBL
      A0A0G2JPD5
    9. XM_005257370.5XP_005257427.1  microtubule-associated protein tau isoform X12

      UniProtKB/TrEMBL
      A0A7P0T936
      Conserved Domains (1) summary
      pfam00418
      Location:312341
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    10. XM_047436080.1XP_047292036.1  microtubule-associated protein tau isoform X15

    11. XM_005257366.4XP_005257423.1  microtubule-associated protein tau isoform X3

      UniProtKB/TrEMBL
      A0A0G2JPD5
      Conserved Domains (1) summary
      pfam00418
      Location:638667
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    12. XM_047436075.1XP_047292031.1  microtubule-associated protein tau isoform X6

      UniProtKB/TrEMBL
      A0A0G2JPD5
    13. XM_047436077.1XP_047292033.1  microtubule-associated protein tau isoform X9

      UniProtKB/TrEMBL
      A0A0G2JPD5
    14. XM_047436078.1XP_047292034.1  microtubule-associated protein tau isoform X10

      UniProtKB/TrEMBL
      A0A0G2JPD5
    15. XM_005257371.5XP_005257428.1  microtubule-associated protein tau isoform X14

      UniProtKB/TrEMBL
      A0A7P0T936
      Conserved Domains (1) summary
      pfam00418
      Location:283312
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    16. XM_047436081.1XP_047292037.1  microtubule-associated protein tau isoform X16

      UniProtKB/TrEMBL
      A0A7P0T936

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      760287..893665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328572.1XP_054184547.1  microtubule-associated protein tau isoform X16

      UniProtKB/TrEMBL
      A0A7P0T936
    2. XM_054328570.1XP_054184545.1  microtubule-associated protein tau isoform X14

      UniProtKB/TrEMBL
      A0A7P0T936
    3. XM_054328566.1XP_054184541.1  microtubule-associated protein tau isoform X3

      UniProtKB/TrEMBL
      A0A0G2JQJ7
    4. XM_054328571.1XP_054184546.1  microtubule-associated protein tau isoform X15

    5. XM_054328569.1XP_054184544.1  microtubule-associated protein tau isoform X12

      UniProtKB/TrEMBL
      A0A7P0T936
    6. XM_054328568.1XP_054184543.1  microtubule-associated protein tau isoform X11

    7. XM_054328567.1XP_054184542.1  microtubule-associated protein tau isoform X5

      UniProtKB/TrEMBL
      A0A0G2JQJ7
    8. XM_054328565.1XP_054184540.1  microtubule-associated protein tau isoform X2

      UniProtKB/TrEMBL
      A0A0G2JQJ7
    9. XM_054328564.1XP_054184539.1  microtubule-associated protein tau isoform X1

      UniProtKB/TrEMBL
      A0A0G2JQJ7

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187663.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      596685..730446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330105.1XP_054186080.1  microtubule-associated protein tau isoform X1

      UniProtKB/TrEMBL
      A0A0G2JPD5
    2. XM_054330106.1XP_054186081.1  microtubule-associated protein tau isoform X2

      UniProtKB/TrEMBL
      A0A0G2JPD5
    3. XM_054330109.1XP_054186084.1  microtubule-associated protein tau isoform X5

      UniProtKB/TrEMBL
      A0A0G2JPD5
    4. XM_054330111.1XP_054186086.1  microtubule-associated protein tau isoform X8

      UniProtKB/TrEMBL
      A0A0G2JPD5
    5. XM_054330113.1XP_054186088.1  microtubule-associated protein tau isoform X11

    6. XM_054330115.1XP_054186090.1  microtubule-associated protein tau isoform X13

    7. XM_054330108.1XP_054186083.1  microtubule-associated protein tau isoform X4

      UniProtKB/TrEMBL
      A0A0G2JPD5
    8. XM_054330110.1XP_054186085.1  microtubule-associated protein tau isoform X7

      UniProtKB/TrEMBL
      A0A0G2JPD5
    9. XM_054330114.1XP_054186089.1  microtubule-associated protein tau isoform X12

      UniProtKB/TrEMBL
      A0A7P0T936
    10. XM_054330117.1XP_054186092.1  microtubule-associated protein tau isoform X15

    11. XM_054330107.1XP_054186082.1  microtubule-associated protein tau isoform X3

      UniProtKB/TrEMBL
      A0A0G2JPD5
    12. XM_054330112.1XP_054186087.1  microtubule-associated protein tau isoform X10

      UniProtKB/TrEMBL
      A0A0G2JPD5
    13. XM_054330116.1XP_054186091.1  microtubule-associated protein tau isoform X14

      UniProtKB/TrEMBL
      A0A7P0T936
    14. XM_054330118.1XP_054186093.1  microtubule-associated protein tau isoform X16

      UniProtKB/TrEMBL
      A0A7P0T936

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      46756177..46889953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316131.1XP_054172106.1  microtubule-associated protein tau isoform X1

      UniProtKB/TrEMBL
      A0A0G2JPD5
    2. XM_054316132.1XP_054172107.1  microtubule-associated protein tau isoform X2

      UniProtKB/TrEMBL
      A0A0G2JPD5
    3. XM_054316135.1XP_054172110.1  microtubule-associated protein tau isoform X5

      UniProtKB/TrEMBL
      A0A0G2JPD5
    4. XM_054316138.1XP_054172113.1  microtubule-associated protein tau isoform X8

      UniProtKB/TrEMBL
      A0A0G2JPD5
    5. XM_054316141.1XP_054172116.1  microtubule-associated protein tau isoform X11

    6. XM_054316143.1XP_054172118.1  microtubule-associated protein tau isoform X13

    7. XM_054316134.1XP_054172109.1  microtubule-associated protein tau isoform X4

      UniProtKB/TrEMBL
      A0A0G2JPD5
    8. XM_054316137.1XP_054172112.1  microtubule-associated protein tau isoform X7

      UniProtKB/TrEMBL
      A0A0G2JPD5
    9. XM_054316142.1XP_054172117.1  microtubule-associated protein tau isoform X12

      UniProtKB/TrEMBL
      A0A7P0T936
    10. XM_054316145.1XP_054172120.1  microtubule-associated protein tau isoform X15

    11. XM_054316133.1XP_054172108.1  microtubule-associated protein tau isoform X3

      UniProtKB/TrEMBL
      A0A0G2JPD5
    12. XM_054316136.1XP_054172111.1  microtubule-associated protein tau isoform X6

      UniProtKB/TrEMBL
      A0A0G2JPD5
    13. XM_054316139.1XP_054172114.1  microtubule-associated protein tau isoform X9

      UniProtKB/TrEMBL
      A0A0G2JPD5
    14. XM_054316140.1XP_054172115.1  microtubule-associated protein tau isoform X10

      UniProtKB/TrEMBL
      A0A0G2JPD5
    15. XM_054316144.1XP_054172119.1  microtubule-associated protein tau isoform X14

      UniProtKB/TrEMBL
      A0A7P0T936
    16. XM_054316146.1XP_054172121.1  microtubule-associated protein tau isoform X16

      UniProtKB/TrEMBL
      A0A7P0T936