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    TLK2 tousled like kinase 2 [ Homo sapiens (human) ]

    Gene ID: 11011, updated on 7-Jan-2024

    Summary

    Official Symbol
    TLK2provided by HGNC
    Official Full Name
    tousled like kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:11842
    See related
    Ensembl:ENSG00000146872 MIM:608439; AllianceGenome:HGNC:11842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HsHPK; MRD57; PKU-ALPHA
    Summary
    This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Broad expression in testis (RPKM 14.1), bone marrow (RPKM 5.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TLK2 in Genome Data Viewer
    Location:
    17q23.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62470914..62615481)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63340853..63485425)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60555172..60692842)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:60500991-60501521 Neighboring gene methyltransferase 2A, tRNA N3-cytidine Neighboring gene uncharacterized LOC112268200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541227-60541728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541729-60542228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8808 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:60562255-60562754 Neighboring gene MPRA-validated peak2934 silencer Neighboring gene ribosomal protein S10 pseudogene 26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:60622822-60623322 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60636816-60637174 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:60642433-60643632 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60645420-60645891 Neighboring gene MPRA-validated peak2935 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60696223-60696734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60702756-60703256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60703257-60703757 Neighboring gene uncharacterized LOC107985020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60707912-60708768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729214-60729925 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729926-60730636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60731349-60732059 Neighboring gene mannose receptor C type 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60743431-60744021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60746820-60747579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60747580-60748338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60748658-60749158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60749159-60749659 Neighboring gene Sharpr-MPRA regulatory region 5505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60757143-60757871 Neighboring gene RNA, U6 small nuclear 446, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of tousled-like kinase 2 (TLK2) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC44450

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in intermediate filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase tousled-like 2
    NP_001271262.1
    NP_001271292.1
    NP_001317347.1
    NP_001362198.1
    NP_001362199.1
    NP_001362200.1
    NP_001362201.1
    NP_001362202.1
    NP_001398003.1
    NP_006843.2
    XP_011522517.2
    XP_011522518.1
    XP_011522520.2
    XP_011522522.2
    XP_011522523.1
    XP_011522524.1
    XP_011522525.1
    XP_011522528.1
    XP_011522529.1
    XP_011522533.2
    XP_016879533.2
    XP_016879537.1
    XP_016879538.1
    XP_016879539.1
    XP_016879540.1
    XP_016879542.1
    XP_016879543.1
    XP_016879544.1
    XP_024306320.1
    XP_024306321.1
    XP_047291130.1
    XP_047291131.1
    XP_047291132.1
    XP_047291133.1
    XP_047291134.1
    XP_047291135.1
    XP_047291136.1
    XP_047291137.1
    XP_047291138.1
    XP_047291139.1
    XP_047291141.1
    XP_047291142.1
    XP_047291143.1
    XP_054170754.1
    XP_054170755.1
    XP_054170756.1
    XP_054170757.1
    XP_054170758.1
    XP_054170759.1
    XP_054170760.1
    XP_054170761.1
    XP_054170762.1
    XP_054170763.1
    XP_054170764.1
    XP_054170765.1
    XP_054170766.1
    XP_054170767.1
    XP_054170768.1
    XP_054170769.1
    XP_054170770.1
    XP_054170771.1
    XP_054170772.1
    XP_054170773.1
    XP_054170774.1
    XP_054170775.1
    XP_054170776.1
    XP_054170777.1
    XP_054170778.1
    XP_054170779.1
    XP_054170780.1
    XP_054170781.1
    XP_054170782.1
    XP_054170783.1
    XP_054170784.1
    XP_054170785.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284333.3NP_001271262.1  serine/threonine-protein kinase tousled-like 2 isoform C

      See identical proteins and their annotated locations for NP_001271262.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) represents the longest transcript and encodes the longest isoform (C).
      Source sequence(s)
      AC080038, AI381985, BC044925, BX647225
      Consensus CDS
      CCDS62283.1
      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000316512.9, ENST00000326270.13
      Conserved Domains (2) summary
      cd14041
      Location:455763
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:202437
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001284363.1NP_001271292.1  serine/threonine-protein kinase tousled-like 2 isoform B

      See identical proteins and their annotated locations for NP_001271292.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant C. The encoded protein (isoform B) is shorter than isoform C.
      Source sequence(s)
      AC008026, AC080038, AK300586, BM668399, BX647225
      Consensus CDS
      CCDS45753.1
      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000508242.1, ENST00000683104.1
      Conserved Domains (2) summary
      COG1196
      Location:174471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:401709
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    3. NM_001330418.3NP_001317347.1  serine/threonine-protein kinase tousled-like 2 isoform D

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038, BM668399
      Consensus CDS
      CCDS82182.1
      UniProtKB/TrEMBL
      B4DUC2, J3QLK5
      Related
      ENSP00000508315.1, ENST00000683536.1
      Conserved Domains (2) summary
      COG1196
      Location:57354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:284592
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    4. NM_001375269.1NP_001362198.1  serine/threonine-protein kinase tousled-like 2 isoform E

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      COG1196
      Location:220517
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:447755
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    5. NM_001375270.1NP_001362199.1  serine/threonine-protein kinase tousled-like 2 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      Consensus CDS
      CCDS11633.1
      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      COG1196
      Location:206503
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:433741
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    6. NM_001375271.1NP_001362200.1  serine/threonine-protein kinase tousled-like 2 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      Consensus CDS
      CCDS11633.1
      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000506744.1, ENST00000682085.1
      Conserved Domains (2) summary
      COG1196
      Location:206503
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:433741
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    7. NM_001375272.1NP_001362201.1  serine/threonine-protein kinase tousled-like 2 isoform B

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      Consensus CDS
      CCDS45753.1
      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000506988.1, ENST00000682075.1
      Conserved Domains (2) summary
      COG1196
      Location:174471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:401709
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    8. NM_001375273.1NP_001362202.1  serine/threonine-protein kinase tousled-like 2 isoform D

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      Consensus CDS
      CCDS82182.1
      UniProtKB/TrEMBL
      B4DUC2, J3QLK5
      Related
      ENSP00000507584.1, ENST00000682203.1
      Conserved Domains (2) summary
      COG1196
      Location:57354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:284592
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    9. NM_001411074.1NP_001398003.1  serine/threonine-protein kinase tousled-like 2 isoform F

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      Consensus CDS
      CCDS92374.1
      UniProtKB/TrEMBL
      A0A804HK10, A0A804HKF1
    10. NM_006852.6NP_006843.2  serine/threonine-protein kinase tousled-like 2 isoform A

      See identical proteins and their annotated locations for NP_006843.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) lacks an alternate in-frame exon in the 3' coding region compared to variant C. The encoded protein (isoform A) is shorter than isoform C.
      Source sequence(s)
      AB004884, AC008026, AC080038, AF162667, AI381985, BX647225
      Consensus CDS
      CCDS11633.1
      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000275780.7, ENST00000346027.10
      Conserved Domains (2) summary
      COG1196
      Location:206503
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:433741
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      62470914..62615481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450552.2XP_024306320.1  serine/threonine-protein kinase tousled-like 2 isoform X7

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:462770
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:209444
      SMC_N; RecF/RecN/SMC N terminal domain
    2. XM_024450553.2XP_024306321.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:455763
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:202437
      SMC_N; RecF/RecN/SMC N terminal domain
    3. XM_047435179.1XP_047291135.1  serine/threonine-protein kinase tousled-like 2 isoform X12

      UniProtKB/TrEMBL
      B4DUC2
    4. XM_011524221.3XP_011522523.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:423731
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:170405
      SMC_N; RecF/RecN/SMC N terminal domain
    5. XM_047435182.1XP_047291138.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2
    6. XM_011524216.3XP_011522518.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      See identical proteins and their annotated locations for XP_011522518.1

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:455763
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:202437
      SMC_N; RecF/RecN/SMC N terminal domain
    7. XM_047435183.1XP_047291139.1  serine/threonine-protein kinase tousled-like 2 isoform X17

      UniProtKB/TrEMBL
      A0A804HKF1
    8. XM_047435185.1XP_047291141.1  serine/threonine-protein kinase tousled-like 2 isoform X19

      UniProtKB/TrEMBL
      A0A804HJZ9, A0A804HKF1
    9. XM_047435180.1XP_047291136.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2
    10. XM_017024053.3XP_016879542.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      COG1196
      Location:174471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:401709
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    11. XM_011524222.4XP_011522524.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      See identical proteins and their annotated locations for XP_011522524.1

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:455763
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:202437
      SMC_N; RecF/RecN/SMC N terminal domain
    12. XM_017024054.3XP_016879543.1  serine/threonine-protein kinase tousled-like 2 isoform X19

      UniProtKB/TrEMBL
      A0A804HJZ9, A0A804HKF1
      Related
      ENSP00000507712.1, ENST00000684440.1
    13. XM_017024048.3XP_016879537.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:423731
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:170405
      SMC_N; RecF/RecN/SMC N terminal domain
    14. XM_017024051.3XP_016879540.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000340800.7, ENST00000343388.11
      Conserved Domains (2) summary
      COG1196
      Location:174471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:401709
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    15. XM_017024055.3XP_016879544.1  serine/threonine-protein kinase tousled-like 2 isoform X21

      UniProtKB/TrEMBL
      A0A804HK10, A0A804HKF1
      Related
      ENSP00000507724.1, ENST00000684772.1
    16. XM_017024049.3XP_016879538.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:423731
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:170405
      SMC_N; RecF/RecN/SMC N terminal domain
    17. XM_011524223.4XP_011522525.1  serine/threonine-protein kinase tousled-like 2 isoform X18

      UniProtKB/TrEMBL
      A0A804HKF1
      Conserved Domains (2) summary
      smart00220
      Location:410678
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14041
      Location:392700
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    18. XM_047435174.1XP_047291130.1  serine/threonine-protein kinase tousled-like 2 isoform X1

      UniProtKB/TrEMBL
      B4DUC2
    19. XM_047435176.1XP_047291132.1  serine/threonine-protein kinase tousled-like 2 isoform X3

      UniProtKB/TrEMBL
      B4DUC2
    20. XM_011524215.3XP_011522517.2  serine/threonine-protein kinase tousled-like 2 isoform X5

      UniProtKB/TrEMBL
      A0A804HKF1
    21. XM_011524218.3XP_011522520.2  serine/threonine-protein kinase tousled-like 2 isoform X9

      UniProtKB/TrEMBL
      A0A804HKF1
    22. XM_011524220.3XP_011522522.2  serine/threonine-protein kinase tousled-like 2 isoform X11

      UniProtKB/TrEMBL
      A0A804HKF1
    23. XM_047435181.1XP_047291137.1  serine/threonine-protein kinase tousled-like 2 isoform X14

      UniProtKB/TrEMBL
      A0A804HKF1
    24. XM_047435177.1XP_047291133.1  serine/threonine-protein kinase tousled-like 2 isoform X6

      UniProtKB/TrEMBL
      B4DUC2
    25. XM_047435178.1XP_047291134.1  serine/threonine-protein kinase tousled-like 2 isoform X10

      UniProtKB/TrEMBL
      B4DUC2
    26. XM_047435175.1XP_047291131.1  serine/threonine-protein kinase tousled-like 2 isoform X2

      UniProtKB/TrEMBL
      B4DUC2
    27. XM_017024044.2XP_016879533.2  serine/threonine-protein kinase tousled-like 2 isoform X4

      UniProtKB/TrEMBL
      B4DUC2
    28. XM_017024050.2XP_016879539.1  serine/threonine-protein kinase tousled-like 2 isoform X15

      UniProtKB/TrEMBL
      A0A804HKF1
      Related
      ENSP00000507902.1, ENST00000684012.1
    29. XM_011524231.2XP_011522533.2  serine/threonine-protein kinase tousled-like 2 isoform X22

    30. XM_011524226.3XP_011522528.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      See identical proteins and their annotated locations for XP_011522528.1

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      smart00220
      Location:369637
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14041
      Location:351659
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    31. XM_011524227.3XP_011522529.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      See identical proteins and their annotated locations for XP_011522529.1

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      smart00220
      Location:369637
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14041
      Location:351659
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    32. XM_047435187.1XP_047291143.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      UniProtKB/TrEMBL
      B4DUC2
    33. XM_047435186.1XP_047291142.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      UniProtKB/TrEMBL
      B4DUC2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      63340853..63485425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314785.1XP_054170760.1  serine/threonine-protein kinase tousled-like 2 isoform X7

      UniProtKB/TrEMBL
      B4DUC2
    2. XM_054314788.1XP_054170763.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2
    3. XM_054314792.1XP_054170767.1  serine/threonine-protein kinase tousled-like 2 isoform X12

      UniProtKB/TrEMBL
      B4DUC2
    4. XM_054314796.1XP_054170771.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2
    5. XM_054314800.1XP_054170775.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2
    6. XM_054314786.1XP_054170761.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2
    7. XM_054314802.1XP_054170777.1  serine/threonine-protein kinase tousled-like 2 isoform X17

      UniProtKB/TrEMBL
      A0A804HKF1
    8. XM_054314804.1XP_054170779.1  serine/threonine-protein kinase tousled-like 2 isoform X19

      UniProtKB/TrEMBL
      A0A804HJZ9, A0A804HKF1
    9. XM_054314794.1XP_054170769.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2
    10. XM_054314799.1XP_054170774.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2
    11. XM_054314787.1XP_054170762.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2
    12. XM_054314805.1XP_054170780.1  serine/threonine-protein kinase tousled-like 2 isoform X19

      UniProtKB/TrEMBL
      A0A804HJZ9, A0A804HKF1
    13. XM_054314795.1XP_054170770.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2
    14. XM_054314801.1XP_054170776.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2
    15. XM_054314809.1XP_054170784.1  serine/threonine-protein kinase tousled-like 2 isoform X21

      UniProtKB/TrEMBL
      A0A804HK10, A0A804HKF1
    16. XM_054314793.1XP_054170768.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2
    17. XM_054314803.1XP_054170778.1  serine/threonine-protein kinase tousled-like 2 isoform X18

      UniProtKB/TrEMBL
      A0A804HKF1
    18. XM_054314779.1XP_054170754.1  serine/threonine-protein kinase tousled-like 2 isoform X1

      UniProtKB/TrEMBL
      B4DUC2
    19. XM_054314781.1XP_054170756.1  serine/threonine-protein kinase tousled-like 2 isoform X3

      UniProtKB/TrEMBL
      B4DUC2
    20. XM_054314783.1XP_054170758.1  serine/threonine-protein kinase tousled-like 2 isoform X5

      UniProtKB/TrEMBL
      A0A804HKF1
    21. XM_054314789.1XP_054170764.1  serine/threonine-protein kinase tousled-like 2 isoform X9

      UniProtKB/TrEMBL
      A0A804HKF1
    22. XM_054314791.1XP_054170766.1  serine/threonine-protein kinase tousled-like 2 isoform X11

      UniProtKB/TrEMBL
      A0A804HKF1
    23. XM_054314797.1XP_054170772.1  serine/threonine-protein kinase tousled-like 2 isoform X14

      UniProtKB/TrEMBL
      A0A804HKF1
    24. XM_054314784.1XP_054170759.1  serine/threonine-protein kinase tousled-like 2 isoform X6

      UniProtKB/TrEMBL
      B4DUC2
    25. XM_054314790.1XP_054170765.1  serine/threonine-protein kinase tousled-like 2 isoform X10

      UniProtKB/TrEMBL
      B4DUC2
    26. XM_054314780.1XP_054170755.1  serine/threonine-protein kinase tousled-like 2 isoform X2

      UniProtKB/TrEMBL
      B4DUC2
    27. XM_054314782.1XP_054170757.1  serine/threonine-protein kinase tousled-like 2 isoform X4

      UniProtKB/TrEMBL
      B4DUC2
    28. XM_054314798.1XP_054170773.1  serine/threonine-protein kinase tousled-like 2 isoform X15

      UniProtKB/TrEMBL
      A0A804HKF1
    29. XM_054314810.1XP_054170785.1  serine/threonine-protein kinase tousled-like 2 isoform X22

    30. XM_054314806.1XP_054170781.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      UniProtKB/TrEMBL
      B4DUC2
    31. XM_054314807.1XP_054170782.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      UniProtKB/TrEMBL
      B4DUC2
    32. XM_054314808.1XP_054170783.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      UniProtKB/TrEMBL
      B4DUC2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001112707.1: Suppressed sequence

      Description
      NM_001112707.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.