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    DPF2 double PHD fingers 2 [ Homo sapiens (human) ]

    Gene ID: 5977, updated on 8-Jul-2024

    Summary

    Official Symbol
    DPF2provided by HGNC
    Official Full Name
    double PHD fingers 2provided by HGNC
    Primary source
    HGNC:HGNC:9964
    See related
    Ensembl:ENSG00000133884 MIM:601671; AllianceGenome:HGNC:9964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    REQ; CSS7; UBID4; ubi-d4; SMARCG2
    Summary
    The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 23.7), ovary (RPKM 23.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DPF2 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65333852..65354262)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65327170..65347565)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65101323..65121733)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3513 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3515 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:65086579-65086802 Neighboring gene CDC42 effector protein 2 Neighboring gene uncharacterized LOC124902691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65104413-65104913 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3521 Neighboring gene Sharpr-MPRA regulatory region 3865 Neighboring gene tigger transposable element derived 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65144096-65144596 Neighboring gene FERM domain containing 8 Neighboring gene solute carrier family 25 member 45 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:65149420-65150619 Neighboring gene Sharpr-MPRA regulatory region 10780

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Coffin-Siris syndrome 7
    MedGen: C4747954 OMIM: 618027 GeneReviews: Coffin-Siris Syndrome
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC10180

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables H3K9me3 modified histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    part_of chromatin HDA PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    part_of nBAF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein ubi-d4
    Names
    BAF45D
    BRG1-associated factor 45D
    D4, zinc and double PHD fingers family 2
    apoptosis response zinc finger protein
    protein requiem
    requiem, apoptosis response zinc finger

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330308.2NP_001317237.1  zinc finger protein ubi-d4 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AI381588, AL555427, AP000944, BI753338, BP201169, CB045170
      Consensus CDS
      CCDS81583.1
      UniProtKB/TrEMBL
      A0A994J426, J3KMZ8
      Related
      ENSP00000252268.4, ENST00000252268.8
      Conserved Domains (4) summary
      COG5189
      Location:201247
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      cd15530
      Location:343388
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15691
      Location:286341
      PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
      pfam14051
      Location:1375
      Requiem_N; N-terminal domain of DPF2/REQ
    2. NM_006268.5NP_006259.1  zinc finger protein ubi-d4 isoform 1

      See identical proteins and their annotated locations for NP_006259.1

      Status: REVIEWED

      Source sequence(s)
      AK313408, AP000944, BC014889
      Consensus CDS
      CCDS8100.1
      UniProtKB/Swiss-Prot
      A8K7C9, B4DT58, Q92785
      UniProtKB/TrEMBL
      A0A994J426
      Related
      ENSP00000436901.1, ENST00000528416.6
      Conserved Domains (4) summary
      COG5189
      Location:201233
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      cd15530
      Location:329374
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15691
      Location:272327
      PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
      pfam14051
      Location:1375
      Requiem_N; N-terminal domain of DPF2/REQ

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      65333852..65354262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018101.3XP_016873590.1  zinc finger protein ubi-d4 isoform X1

      UniProtKB/TrEMBL
      A0A994J426
      Conserved Domains (4) summary
      COG5189
      Location:181227
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      cd15530
      Location:323368
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15691
      Location:266321
      PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
      pfam14051
      Location:155
      Requiem_N; N-terminal domain of DPF2/REQ

    RNA

    1. XR_007062491.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      65327170..65347565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008488422.1 RNA Sequence