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    FSIP2 fibrous sheath interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 401024, updated on 7-Apr-2024

    Summary

    Official Symbol
    FSIP2provided by HGNC
    Official Full Name
    fibrous sheath interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:21675
    See related
    Ensembl:ENSG00000188738 MIM:615796; AllianceGenome:HGNC:21675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPGF34
    Summary
    This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in testis (RPKM 4.0), stomach (RPKM 1.4) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    2q32.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (185737134..185833290)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (186226199..186322363)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (186603531..186698017)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:186432447-186433646 Neighboring gene ELF2 pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:186448047-186448622 Neighboring gene U8 small nucleolar RNA Neighboring gene FSIP2 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12166 Neighboring gene FSIP2 antisense RNA 1 Neighboring gene fibrous sheath interacting protein 2 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:186711714-186712223 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:186729029-186729738 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:186729739-186730447 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:186739935-186740880 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:186740881-186741824 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:186781480-186781581 Neighboring gene MPRA-validated peak3973 silencer Neighboring gene ribosomal protein L21 pseudogene 32

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ34780, FLJ44048, FLJ44063, FLJ44101, FLJ44116, DKFZp781I24108

    General protein information

    Preferred Names
    fibrous sheath-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051365.1 RefSeqGene

      Range
      4910..99396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_173651.4NP_775922.3  fibrous sheath-interacting protein 2

      Status: REVIEWED

      Source sequence(s)
      AC007966, AC008174
      Consensus CDS
      CCDS54426.2
      UniProtKB/Swiss-Prot
      Q53TL3, Q53TN5, Q5CZC0, Q5HYH2, Q6ZTZ5, Q6ZU14, Q6ZU21
      Related
      ENSP00000401306.1, ENST00000424728.6
      Conserved Domains (2) summary
      pfam05672
      Location:213307
      MAP7; MAP7 (E-MAP-115) family
      pfam15783
      Location:59016774
      FSIP2; Fibrous sheath-interacting protein 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      185737134..185833290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444333.1XP_047300289.1  fibrous sheath-interacting protein 2 isoform X3

    2. XM_047444329.1XP_047300285.1  fibrous sheath-interacting protein 2 isoform X1

    3. XM_047444331.1XP_047300287.1  fibrous sheath-interacting protein 2 isoform X2

    4. XM_047444336.1XP_047300292.1  fibrous sheath-interacting protein 2 isoform X5

    5. XM_047444335.1XP_047300291.1  fibrous sheath-interacting protein 2 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      186226199..186322363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342036.1XP_054198011.1  fibrous sheath-interacting protein 2 isoform X3

    2. XM_054342035.1XP_054198010.1  fibrous sheath-interacting protein 2 isoform X1

    3. XM_054342038.1XP_054198013.1  fibrous sheath-interacting protein 2 isoform X4

    4. XM_054342037.1XP_054198012.1  fibrous sheath-interacting protein 2 isoform X2

    5. XM_054342039.1XP_054198014.1  fibrous sheath-interacting protein 2 isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_207482.2: Suppressed sequence

      Description
      NM_207482.2: This RefSeq was permanently suppressed because the CDS was partial.