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    PAK1 p21 (RAC1) activated kinase 1 [ Homo sapiens (human) ]

    Gene ID: 5058, updated on 9-Jun-2024

    Summary

    Official Symbol
    PAK1provided by HGNC
    Official Full Name
    p21 (RAC1) activated kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:8590
    See related
    Ensembl:ENSG00000149269 MIM:602590; AllianceGenome:HGNC:8590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IDDMSSD; p65-PAK; PAKalpha; alpha-PAK
    Summary
    This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
    Expression
    Ubiquitous expression in brain (RPKM 55.5), thyroid (RPKM 19.6) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PAK1 in Genome Data Viewer
    Location:
    11q13.5-q14.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (77322017..77530009, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (77254590..77463028, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77033062..77185139, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene TOMM20 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr11:77106673-77107174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5304 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77159760-77160530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77184247-77185163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:77189428-77189933 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:77190945-77191449 Neighboring gene Sharpr-MPRA regulatory region 3332 Neighboring gene uncharacterized LOC124902722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5307 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:77270938-77272137 Neighboring gene RNA, U7 small nuclear 59 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Intellectual developmental disorder with macrocephaly, seizures, and speech delay
    MedGen: C4748428 OMIM: 618158 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface subsequently activates Cdc42, Pak1, and Wasp, leading to an increase in membrane extensions at the DC surface PubMed
    Nef nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
    nef HIV-1 Nef induces phosphorylation of MEK1 at position serine 298, which depends on Pak and Rac activity. The SH3 region mutation 72PXXP/AXXA75 in Nef results in loss of Pak association which decreases Nef-induced MEK1 phosphorylation PubMed
    nef HIV-1 Nef mutants LLAA and delta12-39 significantly impairs downregulation of CD4. Nef LLAA mutant fails to interact with the endocytic machinery and Nef delta12-39 mutant lacks the interaction with the Nef-associated kinase complex PubMed
    nef The mutation of all four glutamates (amino acids 62-65) to alanine in HIV-1 Nef impairs the ability of Nef to regulate p21-activated protein kinase and enhance viral particle infectivity PubMed
    nef HIV-1 Nef binding and activation of the PAK-related kinase and phosphorylation of its substrate (a complex composed of PIX and p95) are readily detected in both infected primary T lymphocytes and macrophages PubMed
    nef HIV-1 Nef-mediated p21-activated kinase (PAK) activation involves the binding of Nef and phosphatidylinositol 3-kinase (PI3K) PubMed
    nef The activation of Nef-associated kinase (NAK; also known as p21-activated kinase 1 or PAK1) by HIV-1 Nef is via the small GTPases Cdc42 and Rac1, suggesting an interaction between Nef and these GTPases PubMed
    nef HIV-1 Nef-mediated activation of a PAK-related kinase correlates with the induction of high virus loads and the development of AIDS in infected rhesus macaques PubMed
    nef The association of HIV-1 Nef with the cellular serine kinase PAK enhances efficient proviral DNA synthesis and virion infectivity PubMed
    nef A cellular serine kinase is found to specifically associate with HIV-1 Nef; proteins of 62 kDa and 72 kDa, which coimmunoprecipitated with Nef, are phosphorylated in in vitro kinase assays PubMed
    Tat tat Uptake of the HIV-1 Tat protein is regulated by PAK1 activity in epithelial cells PubMed
    tat HIV-1 Tat induces actin cytoskeletal rearrangements through p21-activated kinase 1 (PAK1) and downstream activation of the endothelial NADPH oxidase, an effect that is lost by introduction of mutations into the Tat cysteine-rich or basic domains PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC130000, MGC130001

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables collagen binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables gamma-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    contributes_to small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    NOT involved_in MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell proliferation involved in contact inhibition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular estrogen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercalated disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase PAK 1
    Names
    STE20 homolog, yeast
    p21 protein (Cdc42/Rac)-activated kinase 1
    p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
    p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
    NP_001122092.1
    NP_001363197.1
    NP_001363198.1
    NP_001363199.1
    NP_001363200.1
    NP_001363201.1
    NP_001363202.1
    NP_001363203.1
    NP_001363204.1
    NP_001363205.1
    NP_001363206.1
    NP_001363207.1
    NP_001363208.1
    NP_001363209.1
    NP_001363210.1
    NP_001363211.1
    NP_001363212.1
    NP_001363213.1
    NP_001363214.1
    NP_001363215.1
    NP_001363216.1
    NP_001363217.1
    NP_001363218.1
    NP_001363219.1
    NP_001363220.1
    NP_001363221.1
    NP_001363222.1
    NP_001363223.1
    NP_001363224.1
    NP_001363230.1
    NP_001363231.1
    NP_001363232.1
    NP_001363233.1
    NP_001363234.1
    NP_002567.3
    XP_024304325.1
    XP_024304326.1
    XP_024304327.1
    XP_024304328.1
    XP_047283002.1
    XP_047283003.1
    XP_047283004.1
    XP_047283005.1
    XP_047283006.1
    XP_047283007.1
    XP_047283008.1
    XP_047283009.1
    XP_047283010.1
    XP_054224984.1
    XP_054224985.1
    XP_054224986.1
    XP_054224987.1
    XP_054224988.1
    XP_054224989.1
    XP_054224990.1
    XP_054224991.1
    XP_054224992.1
    XP_054224993.1
    XP_054224994.1
    XP_054224995.1
    XP_054224996.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029900.3 RefSeqGene

      Range
      60915..212992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128620.2NP_001122092.1  serine/threonine-protein kinase PAK 1 isoform 1

      See identical proteins and their annotated locations for NP_001122092.1

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS44687.1
      UniProtKB/TrEMBL
      A8KAN3
      Related
      ENSP00000278568.4, ENST00000278568.8
      Conserved Domains (2) summary
      cd06647
      Location:262517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    2. NM_001376268.1NP_001363197.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS44687.1
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    3. NM_001376269.1NP_001363198.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS44687.1
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    4. NM_001376270.1NP_001363199.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS44687.1
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    5. NM_001376271.1NP_001363200.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS44687.1
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    6. NM_001376272.1NP_001363201.1  serine/threonine-protein kinase PAK 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74135
      PBD; P21-Rho-binding domain
    7. NM_001376273.1NP_001363202.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    8. NM_001376274.1NP_001363203.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    9. NM_001376275.1NP_001363204.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    10. NM_001376276.1NP_001363205.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    11. NM_001376277.1NP_001363206.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    12. NM_001376278.1NP_001363207.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    13. NM_001376279.1NP_001363208.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    14. NM_001376280.1NP_001363209.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    15. NM_001376281.1NP_001363210.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    16. NM_001376282.1NP_001363211.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    17. NM_001376283.1NP_001363212.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    18. NM_001376284.1NP_001363213.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    19. NM_001376285.1NP_001363214.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    20. NM_001376286.1NP_001363215.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    21. NM_001376287.1NP_001363216.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    22. NM_001376288.1NP_001363217.1  serine/threonine-protein kinase PAK 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS91545.1
      UniProtKB/TrEMBL
      A8KAN3, B3KNX7
      Related
      ENSP00000433423.1, ENST00000530617.5
      Conserved Domains (2) summary
      cd06647
      Location:262518
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    23. NM_001376289.1NP_001363218.1  serine/threonine-protein kinase PAK 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
      cl21453
      Location:262471
      PKc_like; Protein Kinases, catalytic domain
    24. NM_001376290.1NP_001363219.1  serine/threonine-protein kinase PAK 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
      cl21453
      Location:249503
      PKc_like; Protein Kinases, catalytic domain
    25. NM_001376291.1NP_001363220.1  serine/threonine-protein kinase PAK 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
      cl21453
      Location:249503
      PKc_like; Protein Kinases, catalytic domain
    26. NM_001376292.1NP_001363221.1  serine/threonine-protein kinase PAK 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
      cl21453
      Location:249498
      PKc_like; Protein Kinases, catalytic domain
    27. NM_001376293.1NP_001363222.1  serine/threonine-protein kinase PAK 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
      cl21453
      Location:249498
      PKc_like; Protein Kinases, catalytic domain
    28. NM_001376294.1NP_001363223.1  serine/threonine-protein kinase PAK 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
      cl21453
      Location:259472
      PKc_like; Protein Kinases, catalytic domain
    29. NM_001376295.1NP_001363224.1  serine/threonine-protein kinase PAK 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
      cl21453
      Location:274485
      PKc_like; Protein Kinases, catalytic domain
    30. NM_001376301.1NP_001363230.1  serine/threonine-protein kinase PAK 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      UniProtKB/TrEMBL
      B7Z3K0
      Conserved Domains (1) summary
      cd06654
      Location:166461
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    31. NM_001376302.1NP_001363231.1  serine/threonine-protein kinase PAK 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS91544.1
      UniProtKB/TrEMBL
      B7Z3K0, E9PM17
      Related
      ENSP00000433211.1, ENST00000528203.5
      Conserved Domains (1) summary
      cd06647
      Location:164419
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    32. NM_001376303.1NP_001363232.1  serine/threonine-protein kinase PAK 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Conserved Domains (2) summary
      cd01093
      Location:73118
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:198448
      PKc_like; Protein Kinases, catalytic domain
    33. NM_001376304.1NP_001363233.1  serine/threonine-protein kinase PAK 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      UniProtKB/TrEMBL
      B7Z3K0
      Conserved Domains (1) summary
      cd06654
      Location:151446
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    34. NM_001376305.1NP_001363234.1  serine/threonine-protein kinase PAK 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      B7Z3K0
      Conserved Domains (1) summary
      cd06654
      Location:151446
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    35. NM_002576.5NP_002567.3  serine/threonine-protein kinase PAK 1 isoform 2

      See identical proteins and their annotated locations for NP_002567.3

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Related
      ENSP00000348696.4, ENST00000356341.8
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain

    RNA

    1. NR_164797.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000486
    2. NR_164798.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000486

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      77322017..77530009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448560.2XP_024304328.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    2. XM_047427054.1XP_047283010.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
    3. XM_047427049.1XP_047283005.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    4. XM_047427051.1XP_047283007.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    5. XM_047427048.1XP_047283004.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    6. XM_024448559.2XP_024304327.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    7. XM_047427053.1XP_047283009.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
    8. XM_047427050.1XP_047283006.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    9. XM_024448557.2XP_024304325.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    10. XM_047427047.1XP_047283003.1  serine/threonine-protein kinase PAK 1 isoform X2

      UniProtKB/TrEMBL
      A8KAN3
    11. XM_047427046.1XP_047283002.1  serine/threonine-protein kinase PAK 1 isoform X1

      UniProtKB/TrEMBL
      A8KAN3
    12. XM_047427052.1XP_047283008.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    13. XM_024448558.2XP_024304326.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      77254590..77463028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369020.1XP_054224995.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
    2. XM_054369019.1XP_054224994.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
    3. XM_054369012.1XP_054224987.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    4. XM_054369017.1XP_054224992.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    5. XM_054369011.1XP_054224986.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    6. XM_054369021.1XP_054224996.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
    7. XM_054369013.1XP_054224988.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    8. XM_054369014.1XP_054224989.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    9. XM_054369016.1XP_054224991.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    10. XM_054369010.1XP_054224985.1  serine/threonine-protein kinase PAK 1 isoform X2

      UniProtKB/TrEMBL
      A8KAN3
    11. XM_054369009.1XP_054224984.1  serine/threonine-protein kinase PAK 1 isoform X1

      UniProtKB/TrEMBL
      A8KAN3
    12. XM_054369018.1XP_054224993.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
    13. XM_054369015.1XP_054224990.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3