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    ADPRS ADP-ribosylserine hydrolase [ Homo sapiens (human) ]

    Gene ID: 54936, updated on 17-Jun-2024

    Summary

    Official Symbol
    ADPRSprovided by HGNC
    Official Full Name
    ADP-ribosylserine hydrolaseprovided by HGNC
    Primary source
    HGNC:HGNC:21304
    See related
    Ensembl:ENSG00000116863 MIM:610624; AllianceGenome:HGNC:21304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARH3; ADPRHL2; CONDSIAS
    Summary
    This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
    Expression
    Ubiquitous expression in testis (RPKM 14.2), lung (RPKM 13.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ADPRS in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (36088892..36093932)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (35951768..35956812)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36554493..36559533)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene magnesium transporter 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36550265-36551063 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36553996-36554581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36554582-36555166 Neighboring gene tektin 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36563075-36563583 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 654 Neighboring gene collagen type VIII alpha 2 chain Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36579590-36580530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36580531-36581471 Neighboring gene MPRA-validated peak176 silencer Neighboring gene trafficking protein particle complex subunit 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:36614757-36615417 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 655

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20446

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in base-excision repair, gap-filling TAS
    Traceable Author Statement
    more info
     
    involved_in cellular response to superoxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of necroptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-serine ADP-deribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ADP-ribosylhydrolase ARH3
    Names
    ADP-ribose glycohydrolase ARH3
    ADP-ribosylarginine hydrolase like 2
    ADP-ribosylhydrolase 3
    ADP-ribosylhydrolase like 2
    O-acetyl-ADP-ribose deacetylase ARH3
    [Protein ADP-ribosylarginine] hydrolase-like protein 2
    [Protein ADP-ribosylserine] hydrolase
    poly(ADP-ribose) glycohydrolase ARH3
    protein ADP-ribosylarginine hydrolase-like protein 2
    NP_060295.1
    XP_011539938.1
    XP_054193231.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017825.3NP_060295.1  ADP-ribosylhydrolase ARH3

      See identical proteins and their annotated locations for NP_060295.1

      Status: REVIEWED

      Source sequence(s)
      BC014169
      Consensus CDS
      CCDS402.1
      UniProtKB/Swiss-Prot
      Q53G94, Q6IAB8, Q9BY47, Q9NX46
      Related
      ENSP00000362273.4, ENST00000373178.5
      Conserved Domains (1) summary
      cl00614
      Location:22339
      ADP_ribosyl_GH; ADP-ribosylglycohydrolase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      36088892..36093932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541636.3XP_011539938.1  ADP-ribosylhydrolase ARH3 isoform X1

      See identical proteins and their annotated locations for XP_011539938.1

      UniProtKB/TrEMBL
      B7ZAN4
      Conserved Domains (1) summary
      pfam03747
      Location:1184
      ADP_ribosyl_GH; ADP-ribosylglycohydrolase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      35951768..35956812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337256.1XP_054193231.1  ADP-ribosylhydrolase ARH3 isoform X1

      UniProtKB/TrEMBL
      B7ZAN4