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    DHX16 DEAH-box helicase 16 [ Homo sapiens (human) ]

    Gene ID: 8449, updated on 3-Apr-2024

    Summary

    Official Symbol
    DHX16provided by HGNC
    Official Full Name
    DEAH-box helicase 16provided by HGNC
    Primary source
    HGNC:HGNC:2739
    See related
    Ensembl:ENSG00000204560 MIM:603405; AllianceGenome:HGNC:2739
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DBP2; PRP8; Prp2; DDX16; NMOAS; PRPF2; PRO2014
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]
    Expression
    Ubiquitous expression in testis (RPKM 17.0), spleen (RPKM 9.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DHX16 in Genome Data Viewer
    Location:
    6p21.33
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30653127..30673006, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30517301..30537211, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30620904..30640783, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30585278-30585846 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene Sharpr-MPRA regulatory region 13793 Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene prothymosin alpha pseudogene 1 Neighboring gene chromosome 6 open reading frame 136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30638704-30639302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30640498-30641094 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:30642736-30642875 Neighboring gene protein phosphatase 1 regulatory subunit 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30649761-30650650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30650651-30651540 Neighboring gene nurim Neighboring gene ribosomal protein L7 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16) at amino acid residues 314-315 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity TAS
    Traceable Author Statement
    more info
     
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pattern recognition receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
    Names
    ATP-dependent RNA helicase #3
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16
    DEAD/H box 16
    DEAH (Asp-Glu-Ala-His) box polypeptide 16
    DEAH-box protein 16
    RNA helicase
    pre-mRNA processing factor 2
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
    NP_001157711.1
    NP_001350444.1
    NP_003578.2
    XP_011513240.1
    XP_011513241.1
    XP_011513243.1
    XP_054185898.1
    XP_054185899.1
    XP_054185900.1
    XP_054186391.1
    XP_054186392.1
    XP_054186393.1
    XP_054186664.1
    XP_054186665.1
    XP_054186666.1
    XP_054186884.1
    XP_054186885.1
    XP_054186886.1
    XP_054187163.1
    XP_054187164.1
    XP_054187165.1
    XP_054187405.1
    XP_054187406.1
    XP_054187407.1
    XP_054212524.1
    XP_054212525.1
    XP_054212526.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164239.2NP_001157711.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 2

      See identical proteins and their annotated locations for NP_001157711.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK302721, BC008825, BQ772493
      UniProtKB/TrEMBL
      A0A1U9X7L6, A0A1U9X7L7
      Conserved Domains (2) summary
      COG1643
      Location:330968
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cl26511
      Location:88316
      Neuromodulin_N; Gap junction protein N-terminal region
    2. NM_001363515.2NP_001350444.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL662798
      Consensus CDS
      CCDS87382.1
      UniProtKB/TrEMBL
      A0A140T8Y5, Q5SQH5, Q9P186
      Related
      ENSP00000365620.5, ENST00000376437.9
      Conserved Domains (1) summary
      COG1643
      Location:7547
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    3. NM_003587.5NP_003578.2  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 1

      See identical proteins and their annotated locations for NP_003578.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC008825, BQ772493, DB072495
      Consensus CDS
      CCDS4685.1
      UniProtKB/Swiss-Prot
      O60231, O60322, Q5JP45, Q969X7, Q96QC1
      UniProtKB/TrEMBL
      A0A1U9X7L6, Q5SQH4
      Related
      ENSP00000365625.3, ENST00000376442.8
      Conserved Domains (2) summary
      PTZ00121
      Location:148376
      PTZ00121; MAEBL; Provisional
      COG1643
      Location:3901028
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      30653127..30673006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514939.3XP_011513241.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

      See identical proteins and their annotated locations for XP_011513241.1

      Conserved Domains (5) summary
      smart00487
      Location:100282
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:499583
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:117256
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:281438
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam07717
      Location:618716
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    2. XM_011514938.3XP_011513240.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

      See identical proteins and their annotated locations for XP_011513240.1

      Conserved Domains (5) summary
      smart00487
      Location:100282
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:499583
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:117256
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:281438
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam07717
      Location:618716
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    3. XM_011514941.4XP_011513243.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X2

      See identical proteins and their annotated locations for XP_011513243.1

      UniProtKB/TrEMBL
      A0A140T8Y5, Q9P186
      Conserved Domains (5) summary
      smart00847
      Location:281365
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:1511
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:138
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:63220
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam07717
      Location:400498
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1988954..2002512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      2132841..2152750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329923.1XP_054185898.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    2. XM_054329924.1XP_054185899.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    3. XM_054329925.1XP_054185900.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      1908950..1928860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330416.1XP_054186391.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    2. XM_054330417.1XP_054186392.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    3. XM_054330418.1XP_054186393.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      1963351..1983259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330689.1XP_054186664.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    2. XM_054330690.1XP_054186665.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    3. XM_054330691.1XP_054186666.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      1997177..2017083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330909.1XP_054186884.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    2. XM_054330910.1XP_054186885.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    3. XM_054330911.1XP_054186886.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      1908209..1928119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331188.1XP_054187163.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    2. XM_054331189.1XP_054187164.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    3. XM_054331190.1XP_054187165.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      1953878..1973789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331430.1XP_054187405.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    2. XM_054331431.1XP_054187406.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    3. XM_054331432.1XP_054187407.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      30517301..30537211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356549.1XP_054212524.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    2. XM_054356550.1XP_054212525.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    3. XM_054356551.1XP_054212526.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X2