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    CALCRL calcitonin receptor like receptor [ Homo sapiens (human) ]

    Gene ID: 10203, updated on 1-Mar-2024

    Summary

    Official Symbol
    CALCRLprovided by HGNC
    Official Full Name
    calcitonin receptor like receptorprovided by HGNC
    Primary source
    HGNC:HGNC:16709
    See related
    Ensembl:ENSG00000064989 MIM:114190; AllianceGenome:HGNC:16709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRLR; CGRPR; LMPHM8
    Summary
    Enables adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in endoplasmic reticulum; endosome; and lysosome. Part of CGRP receptor complex and adrenomedullin receptor complex. Colocalizes with plasma membrane. Implicated in hereditary lymphedema. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung (RPKM 41.7), fat (RPKM 35.2) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CALCRL in Genome Data Viewer
    Location:
    2q32.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (187341964..187448252, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (187831183..187937204, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (188206691..188312979, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CALCRL and TFPI antisense RNA 1 Neighboring gene uncharacterized LOC124906106 Neighboring gene Sharpr-MPRA regulatory region 15485 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:188089626-188090332 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:188128426-188129109 Neighboring gene RNA, U6 small nuclear 989, pseudogene Neighboring gene Sharpr-MPRA regulatory region 15572 Neighboring gene MPRA-validated peak3978 silencer Neighboring gene MPRA-validated peak3980 silencer Neighboring gene MPRA-validated peak3982 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:188273472-188274250 Neighboring gene Sharpr-MPRA regulatory region 13492 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 59 Neighboring gene MPRA-validated peak3983 silencer Neighboring gene MPRA-validated peak3984 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:188384681-188385366 Neighboring gene Sharpr-MPRA regulatory region 10664 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:188411556-188412755 Neighboring gene tissue factor pathway inhibitor Neighboring gene NANOG hESC enhancer GRCh37_chr2:188422204-188422788 Neighboring gene NANOG hESC enhancer GRCh37_chr2:188422789-188423371 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:188430328-188430906 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:188430907-188431484 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:188480540-188481090 Neighboring gene NANOG hESC enhancer GRCh37_chr2:188483510-188484011 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:188535284-188535785 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:188540495-188541307 Neighboring gene MPRA-validated peak3986 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr2:188565262-188565763 Neighboring gene uncharacterized LOC105373788

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables adrenomedullin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables adrenomedullin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adrenomedullin receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcitonin gene-related peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcitonin gene-related peptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcitonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in adrenomedullin receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in adrenomedullin receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcitonin gene-related peptide receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to sucrose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of CGRP receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of adrenomedullin receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of adrenomedullin receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of adrenomedullin receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    calcitonin gene-related peptide type 1 receptor
    Names
    CGRP type 1 receptor
    calcitonin receptor-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271751.2NP_001258680.1  calcitonin gene-related peptide type 1 receptor precursor

      See identical proteins and their annotated locations for NP_001258680.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC007319, AC074020, AK292998
      Consensus CDS
      CCDS2293.1
      UniProtKB/Swiss-Prot
      A8K6G5, A8KAD3, Q16602, Q53S02, Q53TS5
      Related
      ENSP00000387190.1, ENST00000410068.5
      Conserved Domains (2) summary
      pfam02793
      Location:62130
      HRM; Hormone receptor domain
      cd15274
      Location:138411
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    2. NM_001369434.1NP_001356363.1  calcitonin gene-related peptide type 1 receptor precursor

      Status: VALIDATED

      Source sequence(s)
      AC007319, AC074020, KF456755
      Consensus CDS
      CCDS2293.1
      UniProtKB/Swiss-Prot
      A8K6G5, A8KAD3, Q16602, Q53S02, Q53TS5
      Related
      ENSP00000386972.1, ENST00000409998.5
      Conserved Domains (2) summary
      pfam02793
      Location:62130
      HRM; Hormone receptor domain
      cd15274
      Location:138411
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    3. NM_001369435.1NP_001356364.1  calcitonin gene-related peptide type 1 receptor precursor

      Status: VALIDATED

      Source sequence(s)
      AC007319, AC074020, KF456755
      Consensus CDS
      CCDS2293.1
      UniProtKB/Swiss-Prot
      A8K6G5, A8KAD3, Q16602, Q53S02, Q53TS5
      Conserved Domains (2) summary
      pfam02793
      Location:62130
      HRM; Hormone receptor domain
      cd15274
      Location:138411
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    4. NM_005795.6NP_005786.1  calcitonin gene-related peptide type 1 receptor precursor

      See identical proteins and their annotated locations for NP_005786.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC007319, AC074020, DA217003, U17473
      Consensus CDS
      CCDS2293.1
      UniProtKB/Swiss-Prot
      A8K6G5, A8KAD3, Q16602, Q53S02, Q53TS5
      Related
      ENSP00000376177.3, ENST00000392370.8
      Conserved Domains (2) summary
      pfam02793
      Location:62130
      HRM; Hormone receptor domain
      cd15274
      Location:138411
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      187341964..187448252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442888.1XP_047298844.1  calcitonin gene-related peptide type 1 receptor isoform X1

    2. XM_005246232.4XP_005246289.2  calcitonin gene-related peptide type 1 receptor isoform X1

      See identical proteins and their annotated locations for XP_005246289.2

      Conserved Domains (2) summary
      cd15274
      Location:149422
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:73141
      HRM; Hormone receptor domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      187831183..187937204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340129.1XP_054196104.1  calcitonin gene-related peptide type 1 receptor isoform X1

    2. XM_054340128.1XP_054196103.1  calcitonin gene-related peptide type 1 receptor isoform X1